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No significant association between PIK3CA mutation and survival of esophageal squamous cell carcinoma: A meta-analysis.
J Huazhong Univ Sci Technolog Med Sci. 2017 Jun; 37(3):462-468.JH

Abstract

The prognostic value of phosphatidylinositol-4, 5-bisphosphate 3-kinase, catalytic subunit alpha (PIK3CA) in patients with esophageal squamous cell carcinoma (ESCC) is controversial. We aimed to investigate the prognostic significance of PIK3CA mutation in patients with ESCC. EMBASE, PubMed, and Web of Science databases were systematically searched from inception through Oct. 3, 2016. The hazard ratios (HRs) and 95% confidence intervals (CI) were calculated using a random effects model for overall survival (OS) and disease-free survival (DFS). Seven studies enrolling 1505 patients were eligible for inclusion of the current meta-analysis. Results revealed that PIK3CA mutation was not significantly associated with OS (HR: 0.90, 95% CI: 0.63-1.30, P=0.591), with a significant heterogeneity (I 2=65.7%, P=0.012). Additionally, subgroup analyses were further conducted according to various variables, such as types of specimen, the sample size, technique and statistical methodology. All results suggested that no significant relationship was found between PIK3CA mutation and OS in patients with ESCC. For DFS, there was no significant association between PIK3CA mutation and DFS in patients with ESCC (HR: 1.00, 95% CI=0.47-2.11, P=0.993, I 2=73.7%). Publication bias was not present and the results of sensitivity analysis were very stable in the current meta-analysis. Our findings suggest that PIK3CA mutation has no significant effects on OS and DFS in ESCC patients. More well-designed prospective studies with better methodology for PIK3CA assessment are required to clarify the prognostic significance of PIK3CA mutation in ESCC patients.

Authors+Show Affiliations

Department of Thoracic Surgery, the Second Affiliated Hospital of Zhengzhou University, Zhengzhou, 450014, China.Operating Room, the Second Affiliated Hospital of Zhengzhou University, Zhengzhou, 450014, China.Operating Room, the Second Affiliated Hospital of Zhengzhou University, Zhengzhou, 450014, China.Department of Thoracic Surgery, the Second Affiliated Hospital of Zhengzhou University, Zhengzhou, 450014, China.Department of Pathology, the Second Affiliated Hospital of Zhengzhou University, Zhengzhou, 450014, China.Department of Thoracic Surgery, the Second Affiliated Hospital of Zhengzhou University, Zhengzhou, 450014, China.Department of Cardiac Surgery, the Second Affiliated Hospital of Zhengzhou University, Zhengzhou, 450014, China. doctorlob@126.com.

Pub Type(s)

Journal Article
Meta-Analysis

Language

eng

PubMed ID

28585132

Citation

Ge, Xiao-Qing, et al. "No Significant Association Between PIK3CA Mutation and Survival of Esophageal Squamous Cell Carcinoma: a Meta-analysis." Journal of Huazhong University of Science and Technology. Medical Sciences = Hua Zhong Ke Ji Da Xue Xue Bao. Yi Xue Ying De Wen Ban = Huazhong Keji Daxue Xuebao. Yixue Yingdewen Ban, vol. 37, no. 3, 2017, pp. 462-468.
Ge XQ, Yang YZ, Li SS, et al. No significant association between PIK3CA mutation and survival of esophageal squamous cell carcinoma: A meta-analysis. J Huazhong Univ Sci Technol Med Sci. 2017;37(3):462-468.
Ge, X. Q., Yang, Y. Z., Li, S. S., Hou, L., Ren, J. L., Yang, K. P., & Fa, X. E. (2017). No significant association between PIK3CA mutation and survival of esophageal squamous cell carcinoma: A meta-analysis. Journal of Huazhong University of Science and Technology. Medical Sciences = Hua Zhong Ke Ji Da Xue Xue Bao. Yi Xue Ying De Wen Ban = Huazhong Keji Daxue Xuebao. Yixue Yingdewen Ban, 37(3), 462-468. https://doi.org/10.1007/s11596-017-1758-0
Ge XQ, et al. No Significant Association Between PIK3CA Mutation and Survival of Esophageal Squamous Cell Carcinoma: a Meta-analysis. J Huazhong Univ Sci Technol Med Sci. 2017;37(3):462-468. PubMed PMID: 28585132.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - No significant association between PIK3CA mutation and survival of esophageal squamous cell carcinoma: A meta-analysis. AU - Ge,Xiao-Qing, AU - Yang,Yan-Zheng, AU - Li,Sha-Sha, AU - Hou,Lu, AU - Ren,Jing-Li, AU - Yang,Kun-Peng, AU - Fa,Xian-En, Y1 - 2017/06/06/ PY - 2016/11/20/received PY - 2017/05/10/revised PY - 2017/6/7/entrez PY - 2017/6/7/pubmed PY - 2018/3/17/medline KW - 5-bisphosphate 3-kinase KW - catalytic subunit alpha KW - esophageal squamous cell carcinoma KW - meta-analysis KW - phosphatidylinositol-4 KW - prognosis SP - 462 EP - 468 JF - Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban JO - J. Huazhong Univ. Sci. Technol. Med. Sci. VL - 37 IS - 3 N2 - The prognostic value of phosphatidylinositol-4, 5-bisphosphate 3-kinase, catalytic subunit alpha (PIK3CA) in patients with esophageal squamous cell carcinoma (ESCC) is controversial. We aimed to investigate the prognostic significance of PIK3CA mutation in patients with ESCC. EMBASE, PubMed, and Web of Science databases were systematically searched from inception through Oct. 3, 2016. The hazard ratios (HRs) and 95% confidence intervals (CI) were calculated using a random effects model for overall survival (OS) and disease-free survival (DFS). Seven studies enrolling 1505 patients were eligible for inclusion of the current meta-analysis. Results revealed that PIK3CA mutation was not significantly associated with OS (HR: 0.90, 95% CI: 0.63-1.30, P=0.591), with a significant heterogeneity (I 2=65.7%, P=0.012). Additionally, subgroup analyses were further conducted according to various variables, such as types of specimen, the sample size, technique and statistical methodology. All results suggested that no significant relationship was found between PIK3CA mutation and OS in patients with ESCC. For DFS, there was no significant association between PIK3CA mutation and DFS in patients with ESCC (HR: 1.00, 95% CI=0.47-2.11, P=0.993, I 2=73.7%). Publication bias was not present and the results of sensitivity analysis were very stable in the current meta-analysis. Our findings suggest that PIK3CA mutation has no significant effects on OS and DFS in ESCC patients. More well-designed prospective studies with better methodology for PIK3CA assessment are required to clarify the prognostic significance of PIK3CA mutation in ESCC patients. SN - 1993-1352 UR - https://www.unboundmedicine.com/medline/citation/28585132/No_significant_association_between_PIK3CA_mutation_and_survival_of_esophageal_squamous_cell_carcinoma:_A_meta_analysis_ L2 - https://doi.org/10.1007/s11596-017-1758-0 DB - PRIME DP - Unbound Medicine ER -