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Comparative epidemiology of Middle East respiratory syndrome coronavirus (MERS-CoV) in Saudi Arabia and South Korea.
Emerg Microbes Infect. 2017 Jun 07; 6(6):e51.EM

Abstract

MERS-CoV infection emerged in the Kingdom of Saudi Arabia (KSA) in 2012 and has spread to 26 countries. However, 80% of all cases have occurred in KSA. The largest outbreak outside KSA occurred in South Korea (SK) in 2015. In this report, we describe an epidemiological comparison of the two outbreaks. Data from 1299 cases in KSA (2012-2015) and 186 cases in SK (2015) were collected from publicly available resources, including FluTrackers, the World Health Organization (WHO) outbreak news and the Saudi MOH (MOH). Descriptive analysis, t-tests, Chi-square tests and binary logistic regression were conducted to compare demographic and other characteristics (comorbidity, contact history) of cases by nationality. Epidemic curves of the outbreaks were generated. The mean age of cases was 51 years in KSA and 54 years in SK. Older males (⩾70 years) were more likely to be infected or to die from MERS-CoV infection, and males exhibited increased rates of comorbidity in both countries. The epidemic pattern in KSA was more complex, with animal-to-human, human-to-human, nosocomial and unknown exposure, whereas the outbreak in SK was more clearly nosocomial. Of the 1186 MERS cases in KSA with reported risk factors, 158 (13.3%) cases were hospital associated compared with 175 (94.1%) in SK, and an increased proportion of cases with unknown exposure risk was found in KSA (710, 59.9%). In a globally connected world, travel is a risk factor for emerging infections, and health systems in all countries should implement better triage systems for potential imported cases of MERS-CoV to prevent large epidemics.

Authors+Show Affiliations

School of Public Health and Community Medicine, University of New South Wales, Sydney, NSW 2052, Australia.School of Public Health and Community Medicine, University of New South Wales, Sydney, NSW 2052, Australia.School of Public Health and Community Medicine, University of New South Wales, Sydney, NSW 2052, Australia.School of Public Health and Community Medicine, University of New South Wales, Sydney, NSW 2052, Australia. College of Public Service and Community Solutions, Arizona State University, Tempe, AZ 85287, USA.

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

28588290

Citation

Chen, Xin, et al. "Comparative Epidemiology of Middle East Respiratory Syndrome Coronavirus (MERS-CoV) in Saudi Arabia and South Korea." Emerging Microbes & Infections, vol. 6, no. 6, 2017, pp. e51.
Chen X, Chughtai AA, Dyda A, et al. Comparative epidemiology of Middle East respiratory syndrome coronavirus (MERS-CoV) in Saudi Arabia and South Korea. Emerg Microbes Infect. 2017;6(6):e51.
Chen, X., Chughtai, A. A., Dyda, A., & MacIntyre, C. R. (2017). Comparative epidemiology of Middle East respiratory syndrome coronavirus (MERS-CoV) in Saudi Arabia and South Korea. Emerging Microbes & Infections, 6(6), e51. https://doi.org/10.1038/emi.2017.40
Chen X, et al. Comparative Epidemiology of Middle East Respiratory Syndrome Coronavirus (MERS-CoV) in Saudi Arabia and South Korea. Emerg Microbes Infect. 2017 Jun 7;6(6):e51. PubMed PMID: 28588290.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Comparative epidemiology of Middle East respiratory syndrome coronavirus (MERS-CoV) in Saudi Arabia and South Korea. AU - Chen,Xin, AU - Chughtai,Abrar Ahmad, AU - Dyda,Amalie, AU - MacIntyre,Chandini Raina, Y1 - 2017/06/07/ PY - 2016/06/14/received PY - 2017/01/17/revised PY - 2017/03/26/accepted PY - 2017/6/8/entrez PY - 2017/6/8/pubmed PY - 2018/1/3/medline SP - e51 EP - e51 JF - Emerging microbes & infections JO - Emerg Microbes Infect VL - 6 IS - 6 N2 - MERS-CoV infection emerged in the Kingdom of Saudi Arabia (KSA) in 2012 and has spread to 26 countries. However, 80% of all cases have occurred in KSA. The largest outbreak outside KSA occurred in South Korea (SK) in 2015. In this report, we describe an epidemiological comparison of the two outbreaks. Data from 1299 cases in KSA (2012-2015) and 186 cases in SK (2015) were collected from publicly available resources, including FluTrackers, the World Health Organization (WHO) outbreak news and the Saudi MOH (MOH). Descriptive analysis, t-tests, Chi-square tests and binary logistic regression were conducted to compare demographic and other characteristics (comorbidity, contact history) of cases by nationality. Epidemic curves of the outbreaks were generated. The mean age of cases was 51 years in KSA and 54 years in SK. Older males (⩾70 years) were more likely to be infected or to die from MERS-CoV infection, and males exhibited increased rates of comorbidity in both countries. The epidemic pattern in KSA was more complex, with animal-to-human, human-to-human, nosocomial and unknown exposure, whereas the outbreak in SK was more clearly nosocomial. Of the 1186 MERS cases in KSA with reported risk factors, 158 (13.3%) cases were hospital associated compared with 175 (94.1%) in SK, and an increased proportion of cases with unknown exposure risk was found in KSA (710, 59.9%). In a globally connected world, travel is a risk factor for emerging infections, and health systems in all countries should implement better triage systems for potential imported cases of MERS-CoV to prevent large epidemics. SN - 2222-1751 UR - https://www.unboundmedicine.com/medline/citation/28588290/Comparative_epidemiology_of_Middle_East_respiratory_syndrome_coronavirus__MERS_CoV__in_Saudi_Arabia_and_South_Korea_ L2 - https://www.tandfonline.com/doi/full/10.1038/emi.2017.40 DB - PRIME DP - Unbound Medicine ER -