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A comparison of the efficacy of an alpha-I-adrenergic blocker in the slow calcium channel blocker in the control of autonomic dysreflexia.
Paraplegia. 1985 Feb; 23(1):34-8.P

Abstract

Cystometry, using a portable CO2 cystometer, is a convenient method for detecting autonomic dysreflexia (A.D.) in response to bladder distention. Serial tracings on successive days were found to be consistent. This method was used to compare the effect of the antihypertensive drugs, phenoxybenzamine and nifedipine, in modifying the blood pressure responses of 12 tetraplegic patients. Given as regular medication twice daily, neither drug was effective in preventing A.D. responses to bladder filling, and a significant number of patients developed troublesome hypotension. Nifedipine by mouth was found to be a valuable drug for the treatment of attacks which developed, and capable of preventing an anticipated attack if given shortly before the stimulus. The condition of 'status dysreflexicus' and its appropriate management is described.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

2858840

Citation

Lindan, R, et al. "A Comparison of the Efficacy of an alpha-I-adrenergic Blocker in the Slow Calcium Channel Blocker in the Control of Autonomic Dysreflexia." Paraplegia, vol. 23, no. 1, 1985, pp. 34-8.
Lindan R, Leffler EJ, Kedia KR. A comparison of the efficacy of an alpha-I-adrenergic blocker in the slow calcium channel blocker in the control of autonomic dysreflexia. Paraplegia. 1985;23(1):34-8.
Lindan, R., Leffler, E. J., & Kedia, K. R. (1985). A comparison of the efficacy of an alpha-I-adrenergic blocker in the slow calcium channel blocker in the control of autonomic dysreflexia. Paraplegia, 23(1), 34-8.
Lindan R, Leffler EJ, Kedia KR. A Comparison of the Efficacy of an alpha-I-adrenergic Blocker in the Slow Calcium Channel Blocker in the Control of Autonomic Dysreflexia. Paraplegia. 1985;23(1):34-8. PubMed PMID: 2858840.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A comparison of the efficacy of an alpha-I-adrenergic blocker in the slow calcium channel blocker in the control of autonomic dysreflexia. AU - Lindan,R, AU - Leffler,E J, AU - Kedia,K R, PY - 1985/2/1/pubmed PY - 1985/2/1/medline PY - 1985/2/1/entrez SP - 34 EP - 8 JF - Paraplegia JO - Paraplegia VL - 23 IS - 1 N2 - Cystometry, using a portable CO2 cystometer, is a convenient method for detecting autonomic dysreflexia (A.D.) in response to bladder distention. Serial tracings on successive days were found to be consistent. This method was used to compare the effect of the antihypertensive drugs, phenoxybenzamine and nifedipine, in modifying the blood pressure responses of 12 tetraplegic patients. Given as regular medication twice daily, neither drug was effective in preventing A.D. responses to bladder filling, and a significant number of patients developed troublesome hypotension. Nifedipine by mouth was found to be a valuable drug for the treatment of attacks which developed, and capable of preventing an anticipated attack if given shortly before the stimulus. The condition of 'status dysreflexicus' and its appropriate management is described. SN - 0031-1758 UR - https://www.unboundmedicine.com/medline/citation/2858840/A_comparison_of_the_efficacy_of_an_alpha-I-adrenergic_blocker_in_the_slow_calcium_channel_blocker_in_the_control_of_autonomic_dysreflexia L2 - http://dx.doi.org/10.1038/sc.1985.6 DB - PRIME DP - Unbound Medicine ER -