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The Effect of FRAX on the Prediction of Osteoporotic Fractures in Urban Middle-aged and Elderly Healthy Chinese Adults.
Clinics (Sao Paulo). 2017 May; 72(5):289-293.C

Abstract

OBJECTIVE:

We aimed to analyze the applicability of a fracture risk assessment tool for the prediction of osteoporotic fractures in middle-aged and elderly healthy Chinese adults.

METHODS:

A standard questionnaire was administered, and bone mineral density was measured in residents visiting the Dongliu Street Community Health Service Center. Paired t-tests were used to compare the FRAX-based probabilities of fractures estimated with and without consideration of bone mineral density. Risk stratification and partial correlation analyses were applied to analyze the associations between FRAX-based probabilities and body mass index or bone mineral density at different sites.

RESULTS:

A total of 444 subjects were included in this study. Of these subjects, 175 (39.59%) were diagnosed as osteoporotic, and 208 (47.06%) were diagnosed as osteopenic. The Kappa value for the detection of osteoporosis at the L1-L4 lumbar spine and femoral neck was 0.314. The FRAX-based 10-year major osteoporotic fracture probability and hip osteoporotic fracture probability estimated without considering bone mineral density were 4.93% and 1.64%, respectively; when estimated while considering bone mineral density, these probabilities were 4.97% and 1.54%, respectively. A significant positive association was observed between the FRAX-based fracture probabilities estimated with and without consideration of bone mineral density, while significant negative associations between body mass index and the estimated FRAX-based fracture probabilities after adjustment for age and the estimated FRAX-based fracture probabilities and femoral neck bone mineral density were identified. These results remained the same after controlling for lumbar spine bone mineral density.

CONCLUSIONS:

The Chinese FRAX model could predict osteoporotic fracture risk regardless of whether bone mineral density was considered and was especially appropriate for predicting osteoporotic fractures of the femoral neck.

Authors+Show Affiliations

Director's Office, Minglou Street Community Health Service Center, Jiangdong District, Ningbo, China.Director's Office, Dongliu Street Community Health Service Center, Jiangdong District, Ningbo, China.Director's Office, Dongliu Street Community Health Service Center, Jiangdong District, Ningbo, China.Department of Preventive Medicine, Zhejiang Provincial Key Laboratory of Pathophysiology, School of Medicine, Ningbo University, Ningbo, China.Department of Preventive Medicine, Zhejiang Provincial Key Laboratory of Pathophysiology, School of Medicine, Ningbo University, Ningbo, China.

Pub Type(s)

Evaluation Study
Journal Article

Language

eng

PubMed ID

28591341

Citation

Wang, Jun, et al. "The Effect of FRAX On the Prediction of Osteoporotic Fractures in Urban Middle-aged and Elderly Healthy Chinese Adults." Clinics (Sao Paulo, Brazil), vol. 72, no. 5, 2017, pp. 289-293.
Wang J, Wang X, Fang Z, et al. The Effect of FRAX on the Prediction of Osteoporotic Fractures in Urban Middle-aged and Elderly Healthy Chinese Adults. Clinics (Sao Paulo). 2017;72(5):289-293.
Wang, J., Wang, X., Fang, Z., Lu, N., & Han, L. (2017). The Effect of FRAX on the Prediction of Osteoporotic Fractures in Urban Middle-aged and Elderly Healthy Chinese Adults. Clinics (Sao Paulo, Brazil), 72(5), 289-293. https://doi.org/10.6061/clinics/2017(05)06
Wang J, et al. The Effect of FRAX On the Prediction of Osteoporotic Fractures in Urban Middle-aged and Elderly Healthy Chinese Adults. Clinics (Sao Paulo). 2017;72(5):289-293. PubMed PMID: 28591341.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The Effect of FRAX on the Prediction of Osteoporotic Fractures in Urban Middle-aged and Elderly Healthy Chinese Adults. AU - Wang,Jun, AU - Wang,Xuejun, AU - Fang,Zhen, AU - Lu,Nanjia, AU - Han,Liyuan, PY - 2016/10/08/received PY - 2017/02/24/accepted PY - 2017/6/8/entrez PY - 2017/6/8/pubmed PY - 2017/9/26/medline SP - 289 EP - 293 JF - Clinics (Sao Paulo, Brazil) JO - Clinics (Sao Paulo) VL - 72 IS - 5 N2 - OBJECTIVE:: We aimed to analyze the applicability of a fracture risk assessment tool for the prediction of osteoporotic fractures in middle-aged and elderly healthy Chinese adults. METHODS:: A standard questionnaire was administered, and bone mineral density was measured in residents visiting the Dongliu Street Community Health Service Center. Paired t-tests were used to compare the FRAX-based probabilities of fractures estimated with and without consideration of bone mineral density. Risk stratification and partial correlation analyses were applied to analyze the associations between FRAX-based probabilities and body mass index or bone mineral density at different sites. RESULTS:: A total of 444 subjects were included in this study. Of these subjects, 175 (39.59%) were diagnosed as osteoporotic, and 208 (47.06%) were diagnosed as osteopenic. The Kappa value for the detection of osteoporosis at the L1-L4 lumbar spine and femoral neck was 0.314. The FRAX-based 10-year major osteoporotic fracture probability and hip osteoporotic fracture probability estimated without considering bone mineral density were 4.93% and 1.64%, respectively; when estimated while considering bone mineral density, these probabilities were 4.97% and 1.54%, respectively. A significant positive association was observed between the FRAX-based fracture probabilities estimated with and without consideration of bone mineral density, while significant negative associations between body mass index and the estimated FRAX-based fracture probabilities after adjustment for age and the estimated FRAX-based fracture probabilities and femoral neck bone mineral density were identified. These results remained the same after controlling for lumbar spine bone mineral density. CONCLUSIONS:: The Chinese FRAX model could predict osteoporotic fracture risk regardless of whether bone mineral density was considered and was especially appropriate for predicting osteoporotic fractures of the femoral neck. SN - 1980-5322 UR - https://www.unboundmedicine.com/medline/citation/28591341/The_Effect_of_FRAX_on_the_Prediction_of_Osteoporotic_Fractures_in_Urban_Middle_aged_and_Elderly_Healthy_Chinese_Adults_ L2 - http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1807-59322017000500289&lng=en&nrm=iso&tlng=en DB - PRIME DP - Unbound Medicine ER -