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Interaction between genes and macronutrient intake on the risk of developing type 2 diabetes: systematic review and findings from European Prospective Investigation into Cancer (EPIC)-InterAct.
Am J Clin Nutr 2017; 106(1):263-275AJ

Abstract

Background:

Gene-diet interactions have been reported to contribute to the development of type 2 diabetes (T2D). However, to our knowledge, few examples have been consistently replicated to date.

Objective:

We aimed to identify existing evidence for gene-macronutrient interactions and T2D and to examine the reported interactions in a large-scale study.

Design:

We systematically reviewed studies reporting gene-macronutrient interactions and T2D. We searched the MEDLINE, Human Genome Epidemiology Network, and WHO International Clinical Trials Registry Platform electronic databases to identify studies published up to October 2015. Eligibility criteria included assessment of macronutrient quantity (e.g., total carbohydrate) or indicators of quality (e.g., dietary fiber) by use of self-report or objective biomarkers of intake. Interactions identified in the review were subsequently examined in the EPIC (European Prospective Investigation into Cancer)-InterAct case-cohort study (n = 21,148, with 9403 T2D cases; 8 European countries). Prentice-weighted Cox regression was used to estimate country-specific HRs, 95% CIs, and P-interaction values, which were then pooled by random-effects meta-analysis. A primary model was fitted by using the same covariates as reported in the published studies, and a second model adjusted for additional covariates and estimated the effects of isocaloric macronutrient substitution.

Results:

Thirteen observational studies met the eligibility criteria (n < 1700 cases). Eight unique interactions were reported to be significant between macronutrients [carbohydrate, fat, saturated fat, dietary fiber, and glycemic load derived from self-report of dietary intake and circulating n-3 (ω-3) polyunsaturated fatty acids] and genetic variants in or near transcription factor 7-like 2 (TCF7L2), gastric inhibitory polypeptide receptor (GIPR), caveolin 2 (CAV2), and peptidase D (PEPD) (P-interaction < 0.05). We found no evidence of interaction when we tried to replicate previously reported interactions. In addition, no interactions were detected in models with additional covariates.

Conclusions:

Eight gene-macronutrient interactions were identified for the risk of T2D from the literature. These interactions were not replicated in the EPIC-InterAct study, which mirrored the analyses undertaken in the original reports. Our findings highlight the importance of independent replication of reported interactions.

Authors+Show Affiliations

Medical Research Council (MRC) Epidemiology Unit, University of Cambridge, Cambridge, United Kingdom.Medical Research Council (MRC) Epidemiology Unit, University of Cambridge, Cambridge, United Kingdom.Medical Research Council (MRC) Epidemiology Unit, University of Cambridge, Cambridge, United Kingdom.Department of Molecular Epidemiology, German Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal, Germany. German Center for Diabetes Research (DZD), Düsseldorf, Germany.Medical Research Council (MRC) Epidemiology Unit, University of Cambridge, Cambridge, United Kingdom.Navarre Public Health Institute (ISPN), Pamplona, Spain. Center for Biomedical Research in Network Epidemiology and Public Health (CIBERESP), Madrid, Spain.Center for Biomedical Research in Network Epidemiology and Public Health (CIBERESP), Madrid, Spain. Public Health Division of Gipuzkoa, San Sebastian, Spain. Bio-Donostia Institute, Basque Government, San Sebastian, Spain.Department of Molecular Epidemiology, German Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal, Germany.French National Institute of Health and Medical Research (INSERM) U1018, Institut Gustave Roussy, Center for Research in Epidemiology and Population Health (CESP), Villejuif, France. University Paris-Saclay, University Paris-Sud, Villejuif, France.French National Institute of Health and Medical Research (INSERM) U1018, Institut Gustave Roussy, Center for Research in Epidemiology and Population Health (CESP), Villejuif, France. University Paris-Saclay, University Paris-Sud, Villejuif, France.Lund University, Malmö, Sweden. Umeå University, Umeå, Sweden.Catalan Institute of Oncology (ICO), Barcelona, Spain.Epidemiology and Prevention Unit, Milan, Italy.Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany.Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany.University of Oxford, Oxford, United Kingdom.Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom.French National Institute of Health and Medical Research (INSERM) U1018, Institut Gustave Roussy, Center for Research in Epidemiology and Population Health (CESP), Villejuif, France. University Paris-Saclay, University Paris-Sud, Villejuif, France.Center for Biomedical Research in Network Epidemiology and Public Health (CIBERESP), Madrid, Spain. Department of Epidemiology, Murcia Regional Health Council, Biomedical Research Institute of Murcia (IMIB)-Arrixaca, Murcia, Spain. Unit of Preventive Medicine and Public Health, School of Medicine, University of Murcia, Murcia, Spain.Lund University, Malmö, Sweden.University Medical Center Utrecht, Utrecht, Netherlands.Section for Epidemiology, Department of Public Health, Aarhus University, Aarhus, Denmark. Aalborg University Hospital, Aalborg, Denmark.Cancer Research and Prevention Institute (ISPO), Florence, Italy.Department of Clinical Medicine and Surgery, Federico II University, Naples, Italy.Public Health Directorate, Asturias, Spain.Umeå University, Umeå, Sweden.Unit of Cancer Epidemiology, City of Health and Science Hospital, University of Turin, Torino, Italy. Center for Cancer Prevention (CPO), Torino, Italy. Human Genetics Foundation (HuGeF), Torino, Italy.Center for Biomedical Research in Network Epidemiology and Public Health (CIBERESP), Madrid, Spain. Andalusian School of Public Health, Granada, Spain. Biosanitary Research Institute of Granada (Granada.ibs), Granada, Spain.International Agency for Research on Cancer, Lyon, France.University Medical Center Utrecht, Utrecht, Netherlands.National Institute for Public Health and the Environment (RIVM), Bilthoven, Netherlands.Danish Cancer Society Research Center, Copenhagen, Denmark.Provincial Healthcare Company (ASP) Ragusa, Vittoria, Italy; and.Medical Research Council (MRC) Epidemiology Unit, University of Cambridge, Cambridge, United Kingdom.School of Public Health, Imperial College London, London, United Kingdom.Medical Research Council (MRC) Epidemiology Unit, University of Cambridge, Cambridge, United Kingdom.Medical Research Council (MRC) Epidemiology Unit, University of Cambridge, Cambridge, United Kingdom.Medical Research Council (MRC) Epidemiology Unit, University of Cambridge, Cambridge, United Kingdom; nita.forouhi@mrc-epid.cam.ac.uk.Medical Research Council (MRC) Epidemiology Unit, University of Cambridge, Cambridge, United Kingdom.

Pub Type(s)

Journal Article
Meta-Analysis
Systematic Review

Language

eng

PubMed ID

28592605

Citation

Li, Sherly X., et al. "Interaction Between Genes and Macronutrient Intake On the Risk of Developing Type 2 Diabetes: Systematic Review and Findings From European Prospective Investigation Into Cancer (EPIC)-InterAct." The American Journal of Clinical Nutrition, vol. 106, no. 1, 2017, pp. 263-275.
Li SX, Imamura F, Ye Z, et al. Interaction between genes and macronutrient intake on the risk of developing type 2 diabetes: systematic review and findings from European Prospective Investigation into Cancer (EPIC)-InterAct. Am J Clin Nutr. 2017;106(1):263-275.
Li, S. X., Imamura, F., Ye, Z., Schulze, M. B., Zheng, J., Ardanaz, E., ... Wareham, N. J. (2017). Interaction between genes and macronutrient intake on the risk of developing type 2 diabetes: systematic review and findings from European Prospective Investigation into Cancer (EPIC)-InterAct. The American Journal of Clinical Nutrition, 106(1), pp. 263-275. doi:10.3945/ajcn.116.150094.
Li SX, et al. Interaction Between Genes and Macronutrient Intake On the Risk of Developing Type 2 Diabetes: Systematic Review and Findings From European Prospective Investigation Into Cancer (EPIC)-InterAct. Am J Clin Nutr. 2017;106(1):263-275. PubMed PMID: 28592605.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Interaction between genes and macronutrient intake on the risk of developing type 2 diabetes: systematic review and findings from European Prospective Investigation into Cancer (EPIC)-InterAct. AU - Li,Sherly X, AU - Imamura,Fumiaki, AU - Ye,Zheng, AU - Schulze,Matthias B, AU - Zheng,Jusheng, AU - Ardanaz,Eva, AU - Arriola,Larraitz, AU - Boeing,Heiner, AU - Dow,Courtney, AU - Fagherazzi,Guy, AU - Franks,Paul W, AU - Agudo,Antonio, AU - Grioni,Sara, AU - Kaaks,Rudolf, AU - Katzke,Verena A, AU - Key,Timothy J, AU - Khaw,Kay Tee, AU - Mancini,Francesca R, AU - Navarro,Carmen, AU - Nilsson,Peter M, AU - Onland-Moret,N Charlotte, AU - Overvad,Kim, AU - Palli,Domenico, AU - Panico,Salvatore, AU - Quirós,J Ramón, AU - Rolandsson,Olov, AU - Sacerdote,Carlotta, AU - Sánchez,María-José, AU - Slimani,Nadia, AU - Sluijs,Ivonne, AU - Spijkerman,Annemieke Mw, AU - Tjonneland,Anne, AU - Tumino,Rosario, AU - Sharp,Stephen J, AU - Riboli,Elio, AU - Langenberg,Claudia, AU - Scott,Robert A, AU - Forouhi,Nita G, AU - Wareham,Nicholas J, Y1 - 2017/06/07/ PY - 2016/12/17/received PY - 2017/04/26/accepted PY - 2017/6/9/pubmed PY - 2017/8/2/medline PY - 2017/6/9/entrez KW - diabetes KW - diet KW - effect modification KW - gene KW - interaction KW - macronutrient KW - replication KW - systematic review SP - 263 EP - 275 JF - The American journal of clinical nutrition JO - Am. J. Clin. Nutr. VL - 106 IS - 1 N2 - Background: Gene-diet interactions have been reported to contribute to the development of type 2 diabetes (T2D). However, to our knowledge, few examples have been consistently replicated to date.Objective: We aimed to identify existing evidence for gene-macronutrient interactions and T2D and to examine the reported interactions in a large-scale study.Design: We systematically reviewed studies reporting gene-macronutrient interactions and T2D. We searched the MEDLINE, Human Genome Epidemiology Network, and WHO International Clinical Trials Registry Platform electronic databases to identify studies published up to October 2015. Eligibility criteria included assessment of macronutrient quantity (e.g., total carbohydrate) or indicators of quality (e.g., dietary fiber) by use of self-report or objective biomarkers of intake. Interactions identified in the review were subsequently examined in the EPIC (European Prospective Investigation into Cancer)-InterAct case-cohort study (n = 21,148, with 9403 T2D cases; 8 European countries). Prentice-weighted Cox regression was used to estimate country-specific HRs, 95% CIs, and P-interaction values, which were then pooled by random-effects meta-analysis. A primary model was fitted by using the same covariates as reported in the published studies, and a second model adjusted for additional covariates and estimated the effects of isocaloric macronutrient substitution.Results: Thirteen observational studies met the eligibility criteria (n < 1700 cases). Eight unique interactions were reported to be significant between macronutrients [carbohydrate, fat, saturated fat, dietary fiber, and glycemic load derived from self-report of dietary intake and circulating n-3 (ω-3) polyunsaturated fatty acids] and genetic variants in or near transcription factor 7-like 2 (TCF7L2), gastric inhibitory polypeptide receptor (GIPR), caveolin 2 (CAV2), and peptidase D (PEPD) (P-interaction < 0.05). We found no evidence of interaction when we tried to replicate previously reported interactions. In addition, no interactions were detected in models with additional covariates.Conclusions: Eight gene-macronutrient interactions were identified for the risk of T2D from the literature. These interactions were not replicated in the EPIC-InterAct study, which mirrored the analyses undertaken in the original reports. Our findings highlight the importance of independent replication of reported interactions. SN - 1938-3207 UR - https://www.unboundmedicine.com/medline/citation/28592605/Interaction_between_genes_and_macronutrient_intake_on_the_risk_of_developing_type_2_diabetes:_systematic_review_and_findings_from_European_Prospective_Investigation_into_Cancer__EPIC__InterAct_ L2 - https://academic.oup.com/ajcn/article-lookup/doi/10.3945/ajcn.116.150094 DB - PRIME DP - Unbound Medicine ER -