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Radix Bupleuri: A Review of Traditional Uses, Botany, Phytochemistry, Pharmacology, and Toxicology.
Biomed Res Int 2017; 2017:7597596BR

Abstract

Radix Bupleuri (Chaihu) has been used as a traditional medicine for more than 2000 years in China, Japan, Korea, and other Asian countries. Phytochemical studies demonstrated that this plant contains essential oils, triterpenoid saponins, polyacetylenes, flavonoids, lignans, fatty acids, and sterols. Crude extracts and pure compounds isolated from Radix Bupleuri exhibited various biological activities, such as anti-inflammatory, anticancer, antipyretic, antimicrobial, antiviral, hepatoprotective, neuroprotective, and immunomodulatory effects. However, Radix Bupleuri could also lead to hepatotoxicity, particularly in high doses and with long-term use. Pharmacokinetic studies have demonstrated that the major bioactive compounds (saikosaponins a, b2, c, and d) were absorbed rapidly in rats after oral administration of the extract of Radix Bupleuri. This review aims to comprehensively summarize the traditional uses, botany, phytochemistry, pharmacology, toxicology, and pharmacokinetics of Radix Bupleuri reported to date with an emphasis on its biological properties and mechanisms of action.

Authors+Show Affiliations

Gansu University of Chinese Medicine, Lanzhou 730000, China.School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 100102, China.School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 100102, China.School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 100102, China.School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 100102, China.Gansu University of Chinese Medicine, Lanzhou 730000, China. School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 100102, China.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

28593176

Citation

Yang, Fude, et al. "Radix Bupleuri: a Review of Traditional Uses, Botany, Phytochemistry, Pharmacology, and Toxicology." BioMed Research International, vol. 2017, 2017, p. 7597596.
Yang F, Dong X, Yin X, et al. Radix Bupleuri: A Review of Traditional Uses, Botany, Phytochemistry, Pharmacology, and Toxicology. Biomed Res Int. 2017;2017:7597596.
Yang, F., Dong, X., Yin, X., Wang, W., You, L., & Ni, J. (2017). Radix Bupleuri: A Review of Traditional Uses, Botany, Phytochemistry, Pharmacology, and Toxicology. BioMed Research International, 2017, p. 7597596. doi:10.1155/2017/7597596.
Yang F, et al. Radix Bupleuri: a Review of Traditional Uses, Botany, Phytochemistry, Pharmacology, and Toxicology. Biomed Res Int. 2017;2017:7597596. PubMed PMID: 28593176.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Radix Bupleuri: A Review of Traditional Uses, Botany, Phytochemistry, Pharmacology, and Toxicology. AU - Yang,Fude, AU - Dong,Xiaoxv, AU - Yin,Xingbin, AU - Wang,Wenping, AU - You,Longtai, AU - Ni,Jian, Y1 - 2017/05/16/ PY - 2017/02/14/received PY - 2017/04/20/accepted PY - 2017/6/9/entrez PY - 2017/6/9/pubmed PY - 2018/3/8/medline SP - 7597596 EP - 7597596 JF - BioMed research international JO - Biomed Res Int VL - 2017 N2 - Radix Bupleuri (Chaihu) has been used as a traditional medicine for more than 2000 years in China, Japan, Korea, and other Asian countries. Phytochemical studies demonstrated that this plant contains essential oils, triterpenoid saponins, polyacetylenes, flavonoids, lignans, fatty acids, and sterols. Crude extracts and pure compounds isolated from Radix Bupleuri exhibited various biological activities, such as anti-inflammatory, anticancer, antipyretic, antimicrobial, antiviral, hepatoprotective, neuroprotective, and immunomodulatory effects. However, Radix Bupleuri could also lead to hepatotoxicity, particularly in high doses and with long-term use. Pharmacokinetic studies have demonstrated that the major bioactive compounds (saikosaponins a, b2, c, and d) were absorbed rapidly in rats after oral administration of the extract of Radix Bupleuri. This review aims to comprehensively summarize the traditional uses, botany, phytochemistry, pharmacology, toxicology, and pharmacokinetics of Radix Bupleuri reported to date with an emphasis on its biological properties and mechanisms of action. SN - 2314-6141 UR - https://www.unboundmedicine.com/medline/citation/28593176/Radix_Bupleuri:_A_Review_of_Traditional_Uses_Botany_Phytochemistry_Pharmacology_and_Toxicology_ L2 - https://dx.doi.org/10.1155/2017/7597596 DB - PRIME DP - Unbound Medicine ER -