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Multifocal gastric carcinoid tumours, achlorhydria, and hypergastrinaemia.
Lancet 1985; 1(8435):951-4Lct

Abstract

Multiple polypoidal carcinoid tumours of the stomach were found in 5 patients with achlorhydria (4 of whom had pernicious anaemia) as a result of autoimmune atrophic gastritis. The tumours were small (nearly all less than 1 cm diameter) and appeared to grow very slowly, if at all; no significant enlargement or complications were seen during periods of observation of up to 6 years. No extragastric hormonal syndromes were identified. They differed from the carcinoid tumours usually found in the intestinal tract by being composed of argyrophil (not argentaffin) cells of the enterochromaffin-like (ECL) type. Fasting plasma levels of gastrin, which is believed to be trophic to ECL cells, were very high in all patients. Thus, chronic hyperplasia of gastric ECL cells (as a result of hypergastrinaemia) may have been responsible for development of the tumours. Long-term, uninterrupted achlorhydria produced by potent inhibitors of gastric acid secretion might therefore predispose to carcinoid tumours of the stomach.

Authors

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Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

2859413

Citation

Harvey, R F., et al. "Multifocal Gastric Carcinoid Tumours, Achlorhydria, and Hypergastrinaemia." Lancet (London, England), vol. 1, no. 8435, 1985, pp. 951-4.
Harvey RF, Bradshaw MJ, Davidson CM, et al. Multifocal gastric carcinoid tumours, achlorhydria, and hypergastrinaemia. Lancet. 1985;1(8435):951-4.
Harvey, R. F., Bradshaw, M. J., Davidson, C. M., Wilkinson, S. P., & Davies, P. S. (1985). Multifocal gastric carcinoid tumours, achlorhydria, and hypergastrinaemia. Lancet (London, England), 1(8435), pp. 951-4.
Harvey RF, et al. Multifocal Gastric Carcinoid Tumours, Achlorhydria, and Hypergastrinaemia. Lancet. 1985 Apr 27;1(8435):951-4. PubMed PMID: 2859413.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Multifocal gastric carcinoid tumours, achlorhydria, and hypergastrinaemia. AU - Harvey,R F, AU - Bradshaw,M J, AU - Davidson,C M, AU - Wilkinson,S P, AU - Davies,P S, PY - 1985/4/27/pubmed PY - 1985/4/27/medline PY - 1985/4/27/entrez SP - 951 EP - 4 JF - Lancet (London, England) JO - Lancet VL - 1 IS - 8435 N2 - Multiple polypoidal carcinoid tumours of the stomach were found in 5 patients with achlorhydria (4 of whom had pernicious anaemia) as a result of autoimmune atrophic gastritis. The tumours were small (nearly all less than 1 cm diameter) and appeared to grow very slowly, if at all; no significant enlargement or complications were seen during periods of observation of up to 6 years. No extragastric hormonal syndromes were identified. They differed from the carcinoid tumours usually found in the intestinal tract by being composed of argyrophil (not argentaffin) cells of the enterochromaffin-like (ECL) type. Fasting plasma levels of gastrin, which is believed to be trophic to ECL cells, were very high in all patients. Thus, chronic hyperplasia of gastric ECL cells (as a result of hypergastrinaemia) may have been responsible for development of the tumours. Long-term, uninterrupted achlorhydria produced by potent inhibitors of gastric acid secretion might therefore predispose to carcinoid tumours of the stomach. SN - 0140-6736 UR - https://www.unboundmedicine.com/medline/citation/2859413/Multifocal_gastric_carcinoid_tumours_achlorhydria_and_hypergastrinaemia_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0140-6736(85)91727-1 DB - PRIME DP - Unbound Medicine ER -