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Ongoing haemolytic uraemic syndrome (HUS) outbreak caused by sorbitol-fermenting (SF) Shiga toxin-producing Escherichia coli (STEC) O157, Germany, December 2016 to May 2017.
Euro Surveill. 2017 May 25; 22(21)ES

Abstract

We report an ongoing, protracted and geographically dispersed outbreak of haemolytic uraemic syndrome (HUS) and gastroenteritis in Germany, involving 30 cases since December 2016. The outbreak was caused by the sorbitol-fermenting immotile variant of Shiga toxin-producing (STEC) Escherichia coli O157. Molecular typing revealed close relatedness between isolates from 14 cases. One HUS patient died. Results of a case-control study suggest packaged minced meat as the most likely food vehicle. Food safety investigations are ongoing.

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Authors+Show Affiliations

Vygen-Bonnet S
Robert Koch-Institute, Department of Infectious Diseases Epidemiology, Berlin, Germany.
Rosner B
Robert Koch-Institute, Department of Infectious Diseases Epidemiology, Berlin, Germany.
Wilking H
Robert Koch-Institute, Department of Infectious Diseases Epidemiology, Berlin, Germany.
Fruth A
Robert Koch-Institute, Department of Infectious Diseases, National Reference Centre for Salmonella and other Bacterial Enteric Pathogens, Wernigerode, Germany.
Prager R
Robert Koch-Institute, Department of Infectious Diseases, National Reference Centre for Salmonella and other Bacterial Enteric Pathogens, Wernigerode, Germany.
Kossow A
University Hospital of Münster, Consultant Laboratory for HUS, Münster, Germany.
Lang C
Robert Koch-Institute, Department of Infectious Diseases, National Reference Centre for Salmonella and other Bacterial Enteric Pathogens, Wernigerode, Germany.
Simon S
Robert Koch-Institute, Department of Infectious Diseases, National Reference Centre for Salmonella and other Bacterial Enteric Pathogens, Wernigerode, Germany.
Seidel J
Robert Koch-Institute, Department of Infectious Diseases Epidemiology, Berlin, Germany. Postgraduate Training for Applied Epidemiology, Robert Koch Institute, Berlin, Germany. European Programme for Intervention Epidemiology Training (EPIET), European Centre for Disease Prevention and Control (ECDC), Stockholm, Sweden.
Faber M
Robert Koch-Institute, Department of Infectious Diseases Epidemiology, Berlin, Germany.
Schielke A
Robert Koch-Institute, Department of Infectious Diseases Epidemiology, Berlin, Germany.
Michaelis K
Robert Koch-Institute, Department of Infectious Diseases Epidemiology, Berlin, Germany.
Holzer A
Robert Koch-Institute, Department of Infectious Diseases Epidemiology, Berlin, Germany.
Kamphausen R
Ministry of Climate Protection, Environment, Agriculture, Nature Conservation and Consumer Protection of the state of North Rhine-Westphalia, Düsseldorf, Germany.
Kalhöfer D
North Rhine-Westphalia, Centre for Health, Department of Infectiology and Hygiene, Münster, Germany.
Thole S
European Programme for Intervention Epidemiology Training (EPIET), European Centre for Disease Prevention and Control (ECDC), Stockholm, Sweden. North Rhine-Westphalia, Centre for Health, Department of Infectiology and Hygiene, Münster, Germany.
Mellmann A
University Hospital of Münster, Consultant Laboratory for HUS, Münster, Germany.
Flieger A
Robert Koch-Institute, Department of Infectious Diseases, National Reference Centre for Salmonella and other Bacterial Enteric Pathogens, Wernigerode, Germany.
Stark K
Robert Koch-Institute, Department of Infectious Diseases Epidemiology, Berlin, Germany.

MeSH

Case-Control StudiesChildChild, PreschoolDisease OutbreaksElectrophoresis, Gel, Pulsed-FieldEscherichia coli InfectionsEscherichia coli O157FemaleGastroenteritisGermanyHemolytic-Uremic SyndromeHumansInfantInfant, NewbornMeatSerotypingShiga-Toxigenic Escherichia coliSorbitolWhole Genome Sequencing

Pub Type(s)

Journal Article

Language

eng

PubMed ID

28597831

Citation

Vygen-Bonnet, Sabine, et al. "Ongoing Haemolytic Uraemic Syndrome (HUS) Outbreak Caused By Sorbitol-fermenting (SF) Shiga Toxin-producing Escherichia Coli (STEC) O157, Germany, December 2016 to May 2017." Euro Surveillance : Bulletin Europeen Sur Les Maladies Transmissibles = European Communicable Disease Bulletin, vol. 22, no. 21, 2017.
Vygen-Bonnet S, Rosner B, Wilking H, et al. Ongoing haemolytic uraemic syndrome (HUS) outbreak caused by sorbitol-fermenting (SF) Shiga toxin-producing Escherichia coli (STEC) O157, Germany, December 2016 to May 2017. Euro Surveill. 2017;22(21).
Vygen-Bonnet, S., Rosner, B., Wilking, H., Fruth, A., Prager, R., Kossow, A., Lang, C., Simon, S., Seidel, J., Faber, M., Schielke, A., Michaelis, K., Holzer, A., Kamphausen, R., Kalhöfer, D., Thole, S., Mellmann, A., Flieger, A., & Stark, K. (2017). Ongoing haemolytic uraemic syndrome (HUS) outbreak caused by sorbitol-fermenting (SF) Shiga toxin-producing Escherichia coli (STEC) O157, Germany, December 2016 to May 2017. Euro Surveillance : Bulletin Europeen Sur Les Maladies Transmissibles = European Communicable Disease Bulletin, 22(21). https://doi.org/10.2807/1560-7917.ES.2017.22.21.30541
Vygen-Bonnet S, et al. Ongoing Haemolytic Uraemic Syndrome (HUS) Outbreak Caused By Sorbitol-fermenting (SF) Shiga Toxin-producing Escherichia Coli (STEC) O157, Germany, December 2016 to May 2017. Euro Surveill. 2017 May 25;22(21) PubMed PMID: 28597831.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Ongoing haemolytic uraemic syndrome (HUS) outbreak caused by sorbitol-fermenting (SF) Shiga toxin-producing Escherichia coli (STEC) O157, Germany, December 2016 to May 2017. AU - Vygen-Bonnet,Sabine, AU - Rosner,Bettina, AU - Wilking,Hendrik, AU - Fruth,Angelika, AU - Prager,Rita, AU - Kossow,Annelene, AU - Lang,Christina, AU - Simon,Sandra, AU - Seidel,Juliane, AU - Faber,Mirko, AU - Schielke,Anika, AU - Michaelis,Kai, AU - Holzer,Alexandra, AU - Kamphausen,Rolf, AU - Kalhöfer,Daniela, AU - Thole,Sebastian, AU - Mellmann,Alexander, AU - Flieger,Antje, AU - Stark,Klaus, PY - 2017/05/11/received PY - 2017/05/24/accepted PY - 2017/6/10/entrez PY - 2017/6/10/pubmed PY - 2018/3/7/medline KW - HUS KW - Shiga toxin-producing E. coli - STEC KW - food-borne infections KW - haemolytic uraemic syndrome KW - outbreak JF - Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin JO - Euro Surveill VL - 22 IS - 21 N2 - We report an ongoing, protracted and geographically dispersed outbreak of haemolytic uraemic syndrome (HUS) and gastroenteritis in Germany, involving 30 cases since December 2016. The outbreak was caused by the sorbitol-fermenting immotile variant of Shiga toxin-producing (STEC) Escherichia coli O157. Molecular typing revealed close relatedness between isolates from 14 cases. One HUS patient died. Results of a case-control study suggest packaged minced meat as the most likely food vehicle. Food safety investigations are ongoing. SN - 1560-7917 UR - https://www.unboundmedicine.com/medline/citation/28597831/Ongoing_haemolytic_uraemic_syndrome__HUS__outbreak_caused_by_sorbitol_fermenting__SF__Shiga_toxin_producing_Escherichia_coli__STEC__O157_Germany_December_2016_to_May_2017_ DB - PRIME DP - Unbound Medicine ER -