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Meta-analysis: Association of Helicobacter pylori infection with Parkinson's diseases.
Helicobacter. 2017 Oct; 22(5)H

Abstract

BACKGROUND

The results from observational studies on the relationship between helicobacter pylori (H. pylori) infection and Parkinson's disease remain controversial. A meta-analysis was conducted to evaluate the association between helicobacter pylori infection and Parkinson's disease.

METHODS

A comprehensive literature search was performed on relevant studies published from January 1983 to January 2017 in PubMed, Web of Science and EMBASE databases. The fixed or random effects model was used to pool the odds ratio with 95% confidence interval from individual studies. Publication bias was estimated by Egger's test and the funnel plot.

RESULTS

Eight eligible studies involving 33 125 participants were included in this meta-analysis. Compared with the no helicobacter pylori infected person, the pooled odds ratio of Parkinson's disease in helicobacter pylori infected person was 1.59 (95% confidence interval: 1.37-1.85). In subgroup analyzes, the combined odds ratios were 1.96 (1.23-3.12) in Asia, 1.55 (1.32-1.82) in Europe, 1.59 (1.35-1.88) in case-control studies, 1.56 (1.01-2.39) in cross-sectional studies, 1.56 (1.32-1.85) in studies with confounders adjusted, and 1.71 (1.21-2.43) in studies with no confounder adjusted, respectively.

CONCLUSIONS

This meta-analysis indicated that H. pylori infection might be associated with the risk of Parkinson's disease.

Authors+Show Affiliations

Department of Epidemiology and Health Statistics, Qingdao University Medical College, Qingdao, China.Department of Epidemiology and Health Statistics, West China School of Public Health, Sichuan University, Chengdu, China.Department of Epidemiology and Health Statistics, Qingdao University Medical College, Qingdao, China.Department of Epidemiology and Health Statistics, Qingdao University Medical College, Qingdao, China.Departments of Physiology, Qingdao University Medical College, Qingdao, China.

Pub Type(s)

Journal Article
Meta-Analysis
Review

Language

eng

PubMed ID

28598012

Citation

Shen, Xiaoli, et al. "Meta-analysis: Association of Helicobacter Pylori Infection With Parkinson's Diseases." Helicobacter, vol. 22, no. 5, 2017.
Shen X, Yang H, Wu Y, et al. Meta-analysis: Association of Helicobacter pylori infection with Parkinson's diseases. Helicobacter. 2017;22(5).
Shen, X., Yang, H., Wu, Y., Zhang, D., & Jiang, H. (2017). Meta-analysis: Association of Helicobacter pylori infection with Parkinson's diseases. Helicobacter, 22(5). https://doi.org/10.1111/hel.12398
Shen X, et al. Meta-analysis: Association of Helicobacter Pylori Infection With Parkinson's Diseases. Helicobacter. 2017;22(5) PubMed PMID: 28598012.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Meta-analysis: Association of Helicobacter pylori infection with Parkinson's diseases. AU - Shen,Xiaoli, AU - Yang,Huazhen, AU - Wu,Yili, AU - Zhang,Dongfeng, AU - Jiang,Hong, Y1 - 2017/06/09/ PY - 2017/6/10/pubmed PY - 2018/5/9/medline PY - 2017/6/10/entrez KW - helicobacter pylori KW - Parkinson's disease KW - meta-analysis JF - Helicobacter JO - Helicobacter VL - 22 IS - 5 N2 - BACKGROUND: The results from observational studies on the relationship between helicobacter pylori (H. pylori) infection and Parkinson's disease remain controversial. A meta-analysis was conducted to evaluate the association between helicobacter pylori infection and Parkinson's disease. METHODS: A comprehensive literature search was performed on relevant studies published from January 1983 to January 2017 in PubMed, Web of Science and EMBASE databases. The fixed or random effects model was used to pool the odds ratio with 95% confidence interval from individual studies. Publication bias was estimated by Egger's test and the funnel plot. RESULTS: Eight eligible studies involving 33 125 participants were included in this meta-analysis. Compared with the no helicobacter pylori infected person, the pooled odds ratio of Parkinson's disease in helicobacter pylori infected person was 1.59 (95% confidence interval: 1.37-1.85). In subgroup analyzes, the combined odds ratios were 1.96 (1.23-3.12) in Asia, 1.55 (1.32-1.82) in Europe, 1.59 (1.35-1.88) in case-control studies, 1.56 (1.01-2.39) in cross-sectional studies, 1.56 (1.32-1.85) in studies with confounders adjusted, and 1.71 (1.21-2.43) in studies with no confounder adjusted, respectively. CONCLUSIONS: This meta-analysis indicated that H. pylori infection might be associated with the risk of Parkinson's disease. SN - 1523-5378 UR - https://www.unboundmedicine.com/medline/citation/28598012/Meta_analysis:_Association_of_Helicobacter_pylori_infection_with_Parkinson's_diseases_ L2 - https://doi.org/10.1111/hel.12398 DB - PRIME DP - Unbound Medicine ER -