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How do the epidemiology of paediatric methicillin-resistant Staphylococcus aureus and methicillin-susceptible Staphylococcus aureus bacteraemia differ?
J Med Microbiol 2017; 66(6):737-743JM

Abstract

PURPOSE

To examine whether the epidemiology of bacteraemia caused by methicillin-susceptible Staphylococcus aureus (MSSA) and methicillin-resistant S. aureus (MRSA) differed in children aged <1 year and in comparison to older age groups.

METHODOLOGY

English mandatory MRSA and MSSA surveillance data from 2006 and 2011, respectively, were collected. Epidemiological information was descriptively analysed in relation to methicillin susceptibility and patient age. Ninety-five percent confidence intervals (CIs) are reported.Results/Key findings. The average incidence rate of MSSA and MRSA bacteraemia in <1-year-olds was 60.2 and 4.8 episodes per 100 000 population per year, respectively. Of the cases of MSSA bacteraemia in children aged <1 year, 47.5 % (95 % CI: 45.1-50.0; n=760/1 599) were in neonates. With increasing age up to one year, more MSSA bacteraemias were detected ≥7 days after admission, ranging from 0 % (95 % CI: 0-2.5 %) in 0-2-day-olds to 68.4 % (95 % CI: 64.0-72.5 %; 333/487) in 8-28-day-olds and 50.5 % (95 % CI: 47.1-54.0 %; 423/837) in 29 day-1-year-olds, a higher proportion than in older children but similar to MRSA bacteraemia. Amongst <1-year-olds with MSSA bacteraemia, the underlying source was most commonly recorded as intravascular devices [34.4 % (95 %, CI: 30.5-38.6 %); n=190/552] whilst in older age groups this declined. A similar trend was observed for MRSA bacteraemia.

CONCLUSIONS

Our analysis indicates that S. aureus bacteraemia in <1-year-olds is primarily healthcare-associated, unlike MSSA bacteraemia in older age groups. Paediatric-specific interventions targeted at the healthcare setting, such as neonatal unit-specific care bundles and paediatric device-specific strategies, are required.

Authors+Show Affiliations

1​Department of Healthcare-Associated Infection and Antimicrobial Resistance, National Infection Service, Public Health England, London, UK †​Present address: Patient Safety, NHS Improvement, Skipton House, London, UK.2​Paediatric Infection Diseases Research Group, St George's University of London, London, UK.1​Department of Healthcare-Associated Infection and Antimicrobial Resistance, National Infection Service, Public Health England, London, UK.1​Department of Healthcare-Associated Infection and Antimicrobial Resistance, National Infection Service, Public Health England, London, UK.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

28598316

Citation

Abernethy, Julia, et al. "How Do the Epidemiology of Paediatric Methicillin-resistant Staphylococcus Aureus and Methicillin-susceptible Staphylococcus Aureus Bacteraemia Differ?" Journal of Medical Microbiology, vol. 66, no. 6, 2017, pp. 737-743.
Abernethy J, Sharland M, Johnson AP, et al. How do the epidemiology of paediatric methicillin-resistant Staphylococcus aureus and methicillin-susceptible Staphylococcus aureus bacteraemia differ? J Med Microbiol. 2017;66(6):737-743.
Abernethy, J., Sharland, M., Johnson, A. P., & Hope, R. (2017). How do the epidemiology of paediatric methicillin-resistant Staphylococcus aureus and methicillin-susceptible Staphylococcus aureus bacteraemia differ? Journal of Medical Microbiology, 66(6), pp. 737-743. doi:10.1099/jmm.0.000489.
Abernethy J, et al. How Do the Epidemiology of Paediatric Methicillin-resistant Staphylococcus Aureus and Methicillin-susceptible Staphylococcus Aureus Bacteraemia Differ. J Med Microbiol. 2017;66(6):737-743. PubMed PMID: 28598316.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - How do the epidemiology of paediatric methicillin-resistant Staphylococcus aureus and methicillin-susceptible Staphylococcus aureus bacteraemia differ? AU - Abernethy,Julia, AU - Sharland,Mike, AU - Johnson,Alan P, AU - Hope,Russell, Y1 - 2017/06/09/ PY - 2017/6/10/pubmed PY - 2017/7/27/medline PY - 2017/6/10/entrez SP - 737 EP - 743 JF - Journal of medical microbiology JO - J. Med. Microbiol. VL - 66 IS - 6 N2 - PURPOSE: To examine whether the epidemiology of bacteraemia caused by methicillin-susceptible Staphylococcus aureus (MSSA) and methicillin-resistant S. aureus (MRSA) differed in children aged <1 year and in comparison to older age groups. METHODOLOGY: English mandatory MRSA and MSSA surveillance data from 2006 and 2011, respectively, were collected. Epidemiological information was descriptively analysed in relation to methicillin susceptibility and patient age. Ninety-five percent confidence intervals (CIs) are reported.Results/Key findings. The average incidence rate of MSSA and MRSA bacteraemia in <1-year-olds was 60.2 and 4.8 episodes per 100 000 population per year, respectively. Of the cases of MSSA bacteraemia in children aged <1 year, 47.5 % (95 % CI: 45.1-50.0; n=760/1 599) were in neonates. With increasing age up to one year, more MSSA bacteraemias were detected ≥7 days after admission, ranging from 0 % (95 % CI: 0-2.5 %) in 0-2-day-olds to 68.4 % (95 % CI: 64.0-72.5 %; 333/487) in 8-28-day-olds and 50.5 % (95 % CI: 47.1-54.0 %; 423/837) in 29 day-1-year-olds, a higher proportion than in older children but similar to MRSA bacteraemia. Amongst <1-year-olds with MSSA bacteraemia, the underlying source was most commonly recorded as intravascular devices [34.4 % (95 %, CI: 30.5-38.6 %); n=190/552] whilst in older age groups this declined. A similar trend was observed for MRSA bacteraemia. CONCLUSIONS: Our analysis indicates that S. aureus bacteraemia in <1-year-olds is primarily healthcare-associated, unlike MSSA bacteraemia in older age groups. Paediatric-specific interventions targeted at the healthcare setting, such as neonatal unit-specific care bundles and paediatric device-specific strategies, are required. SN - 1473-5644 UR - https://www.unboundmedicine.com/medline/citation/28598316/How_do_the_epidemiology_of_paediatric_methicillin_resistant_Staphylococcus_aureus_and_methicillin_susceptible_Staphylococcus_aureus_bacteraemia_differ L2 - http://jmm.microbiologyresearch.org/pubmed/content/journal/jmm/10.1099/jmm.0.000489 DB - PRIME DP - Unbound Medicine ER -