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Association of maternal weight with FADS and ELOVL genetic variants and fatty acid levels- The PREOBE follow-up.
PLoS One. 2017; 12(6):e0179135.Plos

Abstract

Single nucleotide polymorphisms (SNPs) in the genes encoding the fatty acid desaturase (FADS) and elongase (ELOVL) enzymes affect long-chain polyunsaturated fatty acid (LC-PUFA) production. We aimed to determine if these SNPs are associated with body mass index (BMI) or affect fatty acids (FAs) in pregnant women. Participants (n = 180) from the PREOBE cohort were grouped according to pre-pregnancy BMI: normal-weight (BMI = 18.5-24.9, n = 88) and overweight/obese (BMI≥25, n = 92). Plasma samples were analyzed at 24 weeks of gestation to measure FA levels in the phospholipid fraction. Selected SNPs were genotyped (7 in FADS1, 5 in FADS2, 3 in ELOVL2 and 2 in ELOVL5). Minor allele carriers of rs174545, rs174546, rs174548 and rs174553 (FADS1), and rs1535 and rs174583 (FADS2) were nominally associated with an increased risk of having a BMI≥25. Only for the normal-weight group, minor allele carriers of rs174537, rs174545, rs174546, and rs174553 (FADS1) were negatively associated with AA:DGLA index. Normal-weight women who were minor allele carriers of FADS SNPs had lower levels of AA, AA:DGLA and AA:LA indexes, and higher levels of DGLA, compared to major homozygotes. Among minor allele carriers of FADS2 and ELOVL2 SNPs, overweight/obese women showed higher DHA:EPA index than the normal-weight group; however, they did not present higher DHA concentrations than the normal-weight women. In conclusion, minor allele carriers of FADS SNPs have an increased risk of obesity. Maternal weight changes the effect of genotype on FA levels. Only in the normal-weight group, minor allele carriers of FADS SNPs displayed reduced enzymatic activity and FA levels. This suggests that women with a BMI≥25 are less affected by FADS genetic variants in this regard. In the presence of FADS2 and ELOVL2 SNPs, overweight/obese women showed higher n-3 LC-PUFA production indexes than women with normal weight, but this was not enough to obtain a higher n-3 LC-PUFA concentration.

Authors+Show Affiliations

Department of Nutrition, Food Sciences and Gastronomy, Faculty of Pharmacy and Food Sciences, University of Barcelona, Barcelona, Spain.Food Research and Analysis Institute, University of Santiago de Compostela, Santiago de Compostela, Spain. CIBER Physiopathology of Obesity and Nutrition CIBERobn, Institute of Health Carlos III, Madrid, Spain.Nutrition, Public Health School, Faculty of Health Sciences, University of San Francisco de Quito, Quito, Ecuador.Centre of Excellence for Paediatric Research EURISTIKOS, University of Granada, Granada, Spain. Department of Paediatrics, University of Granada, Granada, Spain.Centre of Excellence for Paediatric Research EURISTIKOS, University of Granada, Granada, Spain. Department of Paediatrics, University of Granada, Granada, Spain.Department of Nutrition, Food Sciences and Gastronomy, Faculty of Pharmacy and Food Sciences, University of Barcelona, Barcelona, Spain.Department of Nutrition, Food Sciences and Gastronomy, Faculty of Pharmacy and Food Sciences, University of Barcelona, Barcelona, Spain.School of Medicine, University of Chimborazo, Riobamba, Ecuador.Department of Nutrition, Food Sciences and Gastronomy, Faculty of Pharmacy and Food Sciences, University of Barcelona, Barcelona, Spain. CIBER Physiopathology of Obesity and Nutrition CIBERobn, Institute of Health Carlos III, Madrid, Spain.Centre of Excellence for Paediatric Research EURISTIKOS, University of Granada, Granada, Spain. Department of Paediatrics, University of Granada, Granada, Spain.Centre of Excellence for Paediatric Research EURISTIKOS, University of Granada, Granada, Spain. Department of Paediatrics, University of Granada, Granada, Spain.Centre of Excellence for Paediatric Research EURISTIKOS, University of Granada, Granada, Spain. Department of Paediatrics, University of Granada, Granada, Spain. CIBER Epidemiology and Public Health CIBEResp, Institute of Health Carlos III, Madrid, Spain.Department of Nutrition, Food Sciences and Gastronomy, Faculty of Pharmacy and Food Sciences, University of Barcelona, Barcelona, Spain. CIBER Physiopathology of Obesity and Nutrition CIBERobn, Institute of Health Carlos III, Madrid, Spain.No affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

28598979

Citation

de la Garza Puentes, Andrea, et al. "Association of Maternal Weight With FADS and ELOVL Genetic Variants and Fatty Acid Levels- the PREOBE Follow-up." PloS One, vol. 12, no. 6, 2017, pp. e0179135.
de la Garza Puentes A, Montes Goyanes R, Chisaguano Tonato AM, et al. Association of maternal weight with FADS and ELOVL genetic variants and fatty acid levels- The PREOBE follow-up. PLoS ONE. 2017;12(6):e0179135.
de la Garza Puentes, A., Montes Goyanes, R., Chisaguano Tonato, A. M., Torres-Espínola, F. J., Arias García, M., de Almeida, L., Bonilla Aguirre, M., Guerendiain, M., Castellote Bargalló, A. I., Segura Moreno, M., García-Valdés, L., Campoy, C., & Lopez-Sabater, M. C. (2017). Association of maternal weight with FADS and ELOVL genetic variants and fatty acid levels- The PREOBE follow-up. PloS One, 12(6), e0179135. https://doi.org/10.1371/journal.pone.0179135
de la Garza Puentes A, et al. Association of Maternal Weight With FADS and ELOVL Genetic Variants and Fatty Acid Levels- the PREOBE Follow-up. PLoS ONE. 2017;12(6):e0179135. PubMed PMID: 28598979.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Association of maternal weight with FADS and ELOVL genetic variants and fatty acid levels- The PREOBE follow-up. AU - de la Garza Puentes,Andrea, AU - Montes Goyanes,Rosa, AU - Chisaguano Tonato,Aida Maribel, AU - Torres-Espínola,Francisco José, AU - Arias García,Miriam, AU - de Almeida,Leonor, AU - Bonilla Aguirre,María, AU - Guerendiain,Marcela, AU - Castellote Bargalló,Ana Isabel, AU - Segura Moreno,Maite, AU - García-Valdés,Luz, AU - Campoy,Cristina, AU - Lopez-Sabater,M Carmen, AU - ,, Y1 - 2017/06/09/ PY - 2016/10/11/received PY - 2017/05/24/accepted PY - 2017/6/10/entrez PY - 2017/6/10/pubmed PY - 2017/9/28/medline SP - e0179135 EP - e0179135 JF - PloS one JO - PLoS ONE VL - 12 IS - 6 N2 - Single nucleotide polymorphisms (SNPs) in the genes encoding the fatty acid desaturase (FADS) and elongase (ELOVL) enzymes affect long-chain polyunsaturated fatty acid (LC-PUFA) production. We aimed to determine if these SNPs are associated with body mass index (BMI) or affect fatty acids (FAs) in pregnant women. Participants (n = 180) from the PREOBE cohort were grouped according to pre-pregnancy BMI: normal-weight (BMI = 18.5-24.9, n = 88) and overweight/obese (BMI≥25, n = 92). Plasma samples were analyzed at 24 weeks of gestation to measure FA levels in the phospholipid fraction. Selected SNPs were genotyped (7 in FADS1, 5 in FADS2, 3 in ELOVL2 and 2 in ELOVL5). Minor allele carriers of rs174545, rs174546, rs174548 and rs174553 (FADS1), and rs1535 and rs174583 (FADS2) were nominally associated with an increased risk of having a BMI≥25. Only for the normal-weight group, minor allele carriers of rs174537, rs174545, rs174546, and rs174553 (FADS1) were negatively associated with AA:DGLA index. Normal-weight women who were minor allele carriers of FADS SNPs had lower levels of AA, AA:DGLA and AA:LA indexes, and higher levels of DGLA, compared to major homozygotes. Among minor allele carriers of FADS2 and ELOVL2 SNPs, overweight/obese women showed higher DHA:EPA index than the normal-weight group; however, they did not present higher DHA concentrations than the normal-weight women. In conclusion, minor allele carriers of FADS SNPs have an increased risk of obesity. Maternal weight changes the effect of genotype on FA levels. Only in the normal-weight group, minor allele carriers of FADS SNPs displayed reduced enzymatic activity and FA levels. This suggests that women with a BMI≥25 are less affected by FADS genetic variants in this regard. In the presence of FADS2 and ELOVL2 SNPs, overweight/obese women showed higher n-3 LC-PUFA production indexes than women with normal weight, but this was not enough to obtain a higher n-3 LC-PUFA concentration. SN - 1932-6203 UR - https://www.unboundmedicine.com/medline/citation/28598979/Association_of_maternal_weight_with_FADS_and_ELOVL_genetic_variants_and_fatty_acid_levels__The_PREOBE_follow_up_ L2 - http://dx.plos.org/10.1371/journal.pone.0179135 DB - PRIME DP - Unbound Medicine ER -