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Omega-3 supplementation on inflammatory markers in patients with chronic Chagas cardiomyopathy: a randomized clinical study.
Nutr J. 2017 Jun 09; 16(1):36.NJ

Abstract

BACKGROUND

Several studies have been focusing on the effect of omega-3 polyunsaturated fatty acids on modulation of inflammatory markers in several cardiopathies. Although immunoregulatory dysfunction has been associated to the chronic cardiac involvement in Chagas disease, there is no study examining the effects of omega-3 supplementation in these patients. We investigated the effects of omega-3 PUFAs on markers of inflammation and lipid profile in chronic Chagas cardiomyopathy patients.

METHODS

The present study was a single-center double-blind clinical trial including patients with chronic Chagas cardiomyopathy. Patients were randomly assigned to receive omega-3 PUFAs capsules (1.8g EPA and 1.2g DHA) or placebo (corn oil) during an 8-week period. Cytokines, fasting glucose, lipid, and anthropometric profiles were evaluated.

RESULTS

Forty-two patients (23 women and 19 men) were included in the study and there were only two losses to follow-up during the 8-week period. Most of sociodemographic and clinical characteristics were similar between the groups at baseline, except for the cytokines IL-1β, IL-6, IL-8, IL-10, IL-17α, and IFNγ. The omega-3 PUFAs group demonstrated greater improvements in serum triglycerides (-21.1 vs. -4.1; p = 0.05) and IL-10 levels (-10.6 vs. -35.7; p = 0.01) in comparison to controls after 8 weeks of intervention. No further differences were observed between groups.

CONCLUSION

Omega-3 PUFAs supplementation may favorably affect lipid and inflammatory profile in chronic Chagas cardiomyopathy patients, demonstrated by a decrease in triglycerides and improvements on IL-10 concentration. Further studies examining the clinical effects of omega-3 fatty acids supplementation in chronic Chagas cardiomyopathy are necessary.

TRIAL REGISTRATION

NCT01863576.

Authors+Show Affiliations

Serviço de Nutrição, Instituto Nacional de Infectologia Evandro Chagas, Fundação Oswaldo Cruz, Av. Brasil 4365, Manguinhos, Rio de Janeiro, Brazil. paula.simplicio@ini.fiocruz.br.Laboratório de Pesquisa Clínica em Doença de Chagas, Instituto de Pesquisa Clínica Evandro Chagas, Fundação Oswaldo Cruz, Av. Brasil 4365, Manguinhos, Rio de Janeiro, Brazil.Laboratório de Pesquisa Clínica em Doença de Chagas, Instituto de Pesquisa Clínica Evandro Chagas, Fundação Oswaldo Cruz, Av. Brasil 4365, Manguinhos, Rio de Janeiro, Brazil.Serviço de Nutrição, Instituto Nacional de Infectologia Evandro Chagas, Fundação Oswaldo Cruz, Av. Brasil 4365, Manguinhos, Rio de Janeiro, Brazil.Serviço de Nutrição, Instituto Nacional de Infectologia Evandro Chagas, Fundação Oswaldo Cruz, Av. Brasil 4365, Manguinhos, Rio de Janeiro, Brazil.Serviço de Nutrição, Instituto Nacional de Infectologia Evandro Chagas, Fundação Oswaldo Cruz, Av. Brasil 4365, Manguinhos, Rio de Janeiro, Brazil.Laboratório de Pesquisa Clínica em Doença de Chagas, Instituto de Pesquisa Clínica Evandro Chagas, Fundação Oswaldo Cruz, Av. Brasil 4365, Manguinhos, Rio de Janeiro, Brazil.Laboratório de Hanseníase, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Av. Brasil 4365, Manguinhos, Rio de Janeiro, Brazil.Laboratório de Pesquisa Clínica em Doença de Chagas, Instituto de Pesquisa Clínica Evandro Chagas, Fundação Oswaldo Cruz, Av. Brasil 4365, Manguinhos, Rio de Janeiro, Brazil.Laboratório de Pesquisa Clínica em Doença de Chagas, Instituto de Pesquisa Clínica Evandro Chagas, Fundação Oswaldo Cruz, Av. Brasil 4365, Manguinhos, Rio de Janeiro, Brazil.Laboratório de Pesquisa Clínica em Doença de Chagas, Instituto de Pesquisa Clínica Evandro Chagas, Fundação Oswaldo Cruz, Av. Brasil 4365, Manguinhos, Rio de Janeiro, Brazil.

Pub Type(s)

Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

28599665

Citation

Silva, Paula Simplício da, et al. "Omega-3 Supplementation On Inflammatory Markers in Patients With Chronic Chagas Cardiomyopathy: a Randomized Clinical Study." Nutrition Journal, vol. 16, no. 1, 2017, p. 36.
Silva PSD, Mediano MFF, Silva GMSD, et al. Omega-3 supplementation on inflammatory markers in patients with chronic Chagas cardiomyopathy: a randomized clinical study. Nutr J. 2017;16(1):36.
Silva, P. S. D., Mediano, M. F. F., Silva, G. M. S. D., Brito, P. D., Cardoso, C. S. A., Almeida, C. F., Sangenis, L. H. C., Pinheiro, R. O., Hasslocher-Moreno, A. M., Brasil, P. E. A. A. D., & Sousa, A. S. (2017). Omega-3 supplementation on inflammatory markers in patients with chronic Chagas cardiomyopathy: a randomized clinical study. Nutrition Journal, 16(1), 36. https://doi.org/10.1186/s12937-017-0259-0
Silva PSD, et al. Omega-3 Supplementation On Inflammatory Markers in Patients With Chronic Chagas Cardiomyopathy: a Randomized Clinical Study. Nutr J. 2017 Jun 9;16(1):36. PubMed PMID: 28599665.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Omega-3 supplementation on inflammatory markers in patients with chronic Chagas cardiomyopathy: a randomized clinical study. AU - Silva,Paula Simplício da, AU - Mediano,Mauro Felippe Felix, AU - Silva,Gilberto Marcelo Sperandio da, AU - Brito,Patricia Dias de, AU - Cardoso,Claudia Santos de Aguiar, AU - Almeida,Cristiane Fonseca de, AU - Sangenis,Luiz Henrique Conde, AU - Pinheiro,Roberta Olmo, AU - Hasslocher-Moreno,Alejandro Marcel, AU - Brasil,Pedro Emmanuel Alvarenga Americano do, AU - Sousa,Andrea Silvestre de, Y1 - 2017/06/09/ PY - 2017/03/10/received PY - 2017/06/05/accepted PY - 2017/6/11/entrez PY - 2017/6/11/pubmed PY - 2018/5/8/medline KW - Chagas cardiomyopathy KW - Chagas disease KW - Cytokines KW - Lipid profile KW - Omega-3 SP - 36 EP - 36 JF - Nutrition journal JO - Nutr J VL - 16 IS - 1 N2 - BACKGROUND: Several studies have been focusing on the effect of omega-3 polyunsaturated fatty acids on modulation of inflammatory markers in several cardiopathies. Although immunoregulatory dysfunction has been associated to the chronic cardiac involvement in Chagas disease, there is no study examining the effects of omega-3 supplementation in these patients. We investigated the effects of omega-3 PUFAs on markers of inflammation and lipid profile in chronic Chagas cardiomyopathy patients. METHODS: The present study was a single-center double-blind clinical trial including patients with chronic Chagas cardiomyopathy. Patients were randomly assigned to receive omega-3 PUFAs capsules (1.8g EPA and 1.2g DHA) or placebo (corn oil) during an 8-week period. Cytokines, fasting glucose, lipid, and anthropometric profiles were evaluated. RESULTS: Forty-two patients (23 women and 19 men) were included in the study and there were only two losses to follow-up during the 8-week period. Most of sociodemographic and clinical characteristics were similar between the groups at baseline, except for the cytokines IL-1β, IL-6, IL-8, IL-10, IL-17α, and IFNγ. The omega-3 PUFAs group demonstrated greater improvements in serum triglycerides (-21.1 vs. -4.1; p = 0.05) and IL-10 levels (-10.6 vs. -35.7; p = 0.01) in comparison to controls after 8 weeks of intervention. No further differences were observed between groups. CONCLUSION: Omega-3 PUFAs supplementation may favorably affect lipid and inflammatory profile in chronic Chagas cardiomyopathy patients, demonstrated by a decrease in triglycerides and improvements on IL-10 concentration. Further studies examining the clinical effects of omega-3 fatty acids supplementation in chronic Chagas cardiomyopathy are necessary. TRIAL REGISTRATION: NCT01863576. SN - 1475-2891 UR - https://www.unboundmedicine.com/medline/citation/28599665/Omega_3_supplementation_on_inflammatory_markers_in_patients_with_chronic_Chagas_cardiomyopathy:_a_randomized_clinical_study_ L2 - https://nutritionj.biomedcentral.com/articles/10.1186/s12937-017-0259-0 DB - PRIME DP - Unbound Medicine ER -