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A new epipolythiodioxopiperazine with antibacterial and cytotoxic activities from the endophytic fungus Chaetomium sp. M336.
Nat Prod Res. 2018 Mar; 32(6):689-694.NP

Abstract

A new compound 6-formamide-chetomin (1) together with chetomin (2) was isolated from solid fermentation products of the endophytic fungus Chaetomium sp. M336, which were elucidated by extensive spectroscopic analyses, including 1D and 2D NMR, and HR-ESI-MS experiments. The bioassay result showed that compound 1 had strong antibacterial activity against Escherichia coli, Staphylococcus aureus, Salmonella typhimurium ATCC 6539 and Enterococcus faecalis with minimum inhibitory concentration (MIC) value of 0.78 μg/mL; meanwhile it exhibited strong cytotoxicity with IC50 values of 21.6-27.1 nM against cell lines HeLa, SGC-7901 and A549.

Authors+Show Affiliations

a State Key Laboratory for Conservation and Utilization of Bio-Resources in Yunnan, and Key Laboratory for Microbial Resources of the Ministry of Education , Yunnan University , Kunming , China. b Faculty of medicine , Kunming University of Science and Technology , Kunming , China.b Faculty of medicine , Kunming University of Science and Technology , Kunming , China.c State Key Laboratory of Phytochemistry and Plant Resources in West China , Kunming Institute of Botany, Chinese Academy of Sciences , Kunming , China.a State Key Laboratory for Conservation and Utilization of Bio-Resources in Yunnan, and Key Laboratory for Microbial Resources of the Ministry of Education , Yunnan University , Kunming , China.a State Key Laboratory for Conservation and Utilization of Bio-Resources in Yunnan, and Key Laboratory for Microbial Resources of the Ministry of Education , Yunnan University , Kunming , China. c State Key Laboratory of Phytochemistry and Plant Resources in West China , Kunming Institute of Botany, Chinese Academy of Sciences , Kunming , China.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

28602097

Citation

Yu, Fei-Xue, et al. "A New Epipolythiodioxopiperazine With Antibacterial and Cytotoxic Activities From the Endophytic Fungus Chaetomium Sp. M336." Natural Product Research, vol. 32, no. 6, 2018, pp. 689-694.
Yu FX, Chen Y, Yang YH, et al. A new epipolythiodioxopiperazine with antibacterial and cytotoxic activities from the endophytic fungus Chaetomium sp. M336. Nat Prod Res. 2018;32(6):689-694.
Yu, F. X., Chen, Y., Yang, Y. H., Li, G. H., & Zhao, P. J. (2018). A new epipolythiodioxopiperazine with antibacterial and cytotoxic activities from the endophytic fungus Chaetomium sp. M336. Natural Product Research, 32(6), 689-694. https://doi.org/10.1080/14786419.2017.1338285
Yu FX, et al. A New Epipolythiodioxopiperazine With Antibacterial and Cytotoxic Activities From the Endophytic Fungus Chaetomium Sp. M336. Nat Prod Res. 2018;32(6):689-694. PubMed PMID: 28602097.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A new epipolythiodioxopiperazine with antibacterial and cytotoxic activities from the endophytic fungus Chaetomium sp. M336. AU - Yu,Fei-Xue, AU - Chen,Yao, AU - Yang,Yin-He, AU - Li,Guo-Hong, AU - Zhao,Pei-Ji, Y1 - 2017/06/12/ PY - 2017/6/13/pubmed PY - 2018/6/12/medline PY - 2017/6/13/entrez KW - 6-Formamide-chetomin KW - Chaetomium sp. M336 KW - antibacterial activities KW - chemical constituents KW - cytotoxicity KW - structure identification SP - 689 EP - 694 JF - Natural product research JO - Nat Prod Res VL - 32 IS - 6 N2 - A new compound 6-formamide-chetomin (1) together with chetomin (2) was isolated from solid fermentation products of the endophytic fungus Chaetomium sp. M336, which were elucidated by extensive spectroscopic analyses, including 1D and 2D NMR, and HR-ESI-MS experiments. The bioassay result showed that compound 1 had strong antibacterial activity against Escherichia coli, Staphylococcus aureus, Salmonella typhimurium ATCC 6539 and Enterococcus faecalis with minimum inhibitory concentration (MIC) value of 0.78 μg/mL; meanwhile it exhibited strong cytotoxicity with IC50 values of 21.6-27.1 nM against cell lines HeLa, SGC-7901 and A549. SN - 1478-6427 UR - https://www.unboundmedicine.com/medline/citation/28602097/A_new_epipolythiodioxopiperazine_with_antibacterial_and_cytotoxic_activities_from_the_endophytic_fungus_Chaetomium_sp__M336_ L2 - https://www.tandfonline.com/doi/full/10.1080/14786419.2017.1338285 DB - PRIME DP - Unbound Medicine ER -