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Dietary inflammatory index before diagnosis and survival in an Italian cohort of women with breast cancer.
Br J Nutr 2017; 117(10):1456-1462BJ

Abstract

The dietary inflammatory indexTM (DII) has been shown to correlate with concentrations of several inflammatory markers and a variety of chronic disease endpoints, including cancers of various anatomic sites. We investigated whether the DII was associated with the risk for death among women with breast cancer (BrCa). This retrospective cohort study included 1453 women with BrCa, diagnosed between 1990 and 1994, and previously enrolled in a case-control study in northern Italy. With a median follow-up of 12·6 years, we observed 503 deaths, among which 398 were due to BrCa. The usual diet was assessed at BrCa diagnosis using a validated FFQ. DII scores were calculated using thirty-one foods/nutrients. Hazard ratios (HR) of death from all causes or from BrCa, with corresponding 95 % CI, were calculated using the Cox models, adjusted for age at diagnosis, tumour stage, oestrogen/progesterone receptor status and other potential confounders. The median DII score of the study women was -1·23, with a relatively narrow range (interquartile range -2·24 to -0·11), indicating a mainly anti-inflammatory diet. There was no difference in survival according to DII tertiles, neither considering all-cause mortality (HRtertile III v. I 1·00; 95 % CI 0·78, 1·28) nor BrCa-specific mortality (HRtertile III v. I 0·97; 95 % CI 0·73, 1·27). Study findings did not suggest an association between the inflammatory potential of diet, measured by the DII, and the survival of BrCa women. However, further studies are needed in populations reporting higher DII scores and a broader range of variability in the scores.

Authors+Show Affiliations

1Unit of Cancer Epidemiology,Centro di Riferimento Oncologico (CRO) Aviano National Cancer Institute,Aviano (PN), 33081,Italy.1Unit of Cancer Epidemiology,Centro di Riferimento Oncologico (CRO) Aviano National Cancer Institute,Aviano (PN), 33081,Italy.2Cancer Prevention and Control Program,University of South Carolina,Columbia,SC 29208,USA.2Cancer Prevention and Control Program,University of South Carolina,Columbia,SC 29208,USA.5Venetian Cancer Registry,Veneto Region,Padua, 35131,Italy.6Cancer Registry of Liguria Region,Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Azienda Ospedaliera Universitaria San Martino/Istituto Nazionale per la Ricerca sul Cancro (IST),Genova, 16132,Italy.7Romagna Cancer Registry,Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST),Meldola,Forlì, 47014,Italy.1Unit of Cancer Epidemiology,Centro di Riferimento Oncologico (CRO) Aviano National Cancer Institute,Aviano (PN), 33081,Italy.1Unit of Cancer Epidemiology,Centro di Riferimento Oncologico (CRO) Aviano National Cancer Institute,Aviano (PN), 33081,Italy.1Unit of Cancer Epidemiology,Centro di Riferimento Oncologico (CRO) Aviano National Cancer Institute,Aviano (PN), 33081,Italy.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

28606221

Citation

Zucchetto, Antonella, et al. "Dietary Inflammatory Index Before Diagnosis and Survival in an Italian Cohort of Women With Breast Cancer." The British Journal of Nutrition, vol. 117, no. 10, 2017, pp. 1456-1462.
Zucchetto A, Serraino D, Shivappa N, et al. Dietary inflammatory index before diagnosis and survival in an Italian cohort of women with breast cancer. Br J Nutr. 2017;117(10):1456-1462.
Zucchetto, A., Serraino, D., Shivappa, N., Hébert, J. R., Stocco, C., Puppo, A., ... Polesel, J. (2017). Dietary inflammatory index before diagnosis and survival in an Italian cohort of women with breast cancer. The British Journal of Nutrition, 117(10), pp. 1456-1462. doi:10.1017/S0007114517001258.
Zucchetto A, et al. Dietary Inflammatory Index Before Diagnosis and Survival in an Italian Cohort of Women With Breast Cancer. Br J Nutr. 2017;117(10):1456-1462. PubMed PMID: 28606221.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Dietary inflammatory index before diagnosis and survival in an Italian cohort of women with breast cancer. AU - Zucchetto,Antonella, AU - Serraino,Diego, AU - Shivappa,Nitin, AU - Hébert,James R, AU - Stocco,Carmen, AU - Puppo,Antonella, AU - Falcini,Fabio, AU - Panato,Chiara, AU - Dal Maso,Luigino, AU - Polesel,Jerry, Y1 - 2017/06/13/ PY - 2017/6/14/pubmed PY - 2017/7/25/medline PY - 2017/6/14/entrez KW - BrCa breast cancer KW - DII dietary inflammatory index KW - ER oestrogen receptor KW - HR hazard ratios KW - PR progesterone receptor KW - Breast cancer KW - Dietary inflammatory index KW - Diets KW - Inflammation KW - Survival SP - 1456 EP - 1462 JF - The British journal of nutrition JO - Br. J. Nutr. VL - 117 IS - 10 N2 - The dietary inflammatory indexTM (DII) has been shown to correlate with concentrations of several inflammatory markers and a variety of chronic disease endpoints, including cancers of various anatomic sites. We investigated whether the DII was associated with the risk for death among women with breast cancer (BrCa). This retrospective cohort study included 1453 women with BrCa, diagnosed between 1990 and 1994, and previously enrolled in a case-control study in northern Italy. With a median follow-up of 12·6 years, we observed 503 deaths, among which 398 were due to BrCa. The usual diet was assessed at BrCa diagnosis using a validated FFQ. DII scores were calculated using thirty-one foods/nutrients. Hazard ratios (HR) of death from all causes or from BrCa, with corresponding 95 % CI, were calculated using the Cox models, adjusted for age at diagnosis, tumour stage, oestrogen/progesterone receptor status and other potential confounders. The median DII score of the study women was -1·23, with a relatively narrow range (interquartile range -2·24 to -0·11), indicating a mainly anti-inflammatory diet. There was no difference in survival according to DII tertiles, neither considering all-cause mortality (HRtertile III v. I 1·00; 95 % CI 0·78, 1·28) nor BrCa-specific mortality (HRtertile III v. I 0·97; 95 % CI 0·73, 1·27). Study findings did not suggest an association between the inflammatory potential of diet, measured by the DII, and the survival of BrCa women. However, further studies are needed in populations reporting higher DII scores and a broader range of variability in the scores. SN - 1475-2662 UR - https://www.unboundmedicine.com/medline/citation/28606221/Dietary_inflammatory_index_before_diagnosis_and_survival_in_an_Italian_cohort_of_women_with_breast_cancer_ L2 - https://www.cambridge.org/core/product/identifier/S0007114517001258/type/journal_article DB - PRIME DP - Unbound Medicine ER -