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Effect of ω-3 polyunsaturated fatty acids on arthritic pain: A systematic review.
Nutrition. 2017 Jul - Aug; 39-40:57-66.N

Abstract

OBJECTIVES

Pain is a significant problem in rheumatoid arthritis (RA) and is associated with prostaglandins derived from the ω-6 polyunsaturated fatty acid (PUFA) arachidonic acid. The ω-3 PUFAs eicosapentaenoic acid and docosahexaenoic acid have been shown to reduce inflammation, with some studies showing clinical improvements in RA. The aim of this systematic review was to investigate the effect of ω-3 PUFAs on arthritic pain.

METHOD

A systematic literature review of ω-3 PUFAs and pain associated with RA was performed up to December 2015. Randomized controlled trials (RCTs) investigating the effect of ω-3 PUFAs (>2 g/d) on patient or physician assessment of pain, or assessment by both patient and physician, were included. The Cochrane Collaboration's tool for assessing risk for bias was employed. Data for outcomes of interest were extracted and collated for interpretation.

RESULTS

Eighteen RCTs published between 1985 and 2013 involving 1143 patients were included. Dosage of ω-3 PUFAs used was 2.1 to 9.1 g/d, with study durations of 12 to 52 wk. Ten studies supported the hypothesis that there is a reduction in patient or physician assessment of pain associated with RA after intake of ω-3 PUFAs. Eight studies found no statistically significant effect of ω-3 PUFAs on arthritic pain.

CONCLUSIONS

ω-3 PUFAs may have a therapeutic role in decreasing pain associated with RA, with doses of 3 to 6 g/d appearing to have a greater effect. Due to the limitations identified in the RCTs included in this review, more research is needed to investigate ω-3 PUFAs in larger populations and over extended periods of time.

Authors+Show Affiliations

Human Development and Health Academic Unit, Faculty of Medicine, University of Southampton, Southampton, United Kingdom.Human Development and Health Academic Unit, Faculty of Medicine, University of Southampton, Southampton, United Kingdom.Human Development and Health Academic Unit, Faculty of Medicine, University of Southampton, Southampton, United Kingdom; National Institute for Health Research Southampton Biomedical Research Centre, University Hospital Southampton NHS Foundation Trust and University of Southampton, Southampton, United Kingdom. Electronic address: Pcc@soton.ac.uk.

Pub Type(s)

Journal Article
Review
Systematic Review

Language

eng

PubMed ID

28606571

Citation

Abdulrazaq, Mozghan, et al. "Effect of Ω-3 Polyunsaturated Fatty Acids On Arthritic Pain: a Systematic Review." Nutrition (Burbank, Los Angeles County, Calif.), vol. 39-40, 2017, pp. 57-66.
Abdulrazaq M, Innes JK, Calder PC. Effect of ω-3 polyunsaturated fatty acids on arthritic pain: A systematic review. Nutrition. 2017;39-40:57-66.
Abdulrazaq, M., Innes, J. K., & Calder, P. C. (2017). Effect of ω-3 polyunsaturated fatty acids on arthritic pain: A systematic review. Nutrition (Burbank, Los Angeles County, Calif.), 39-40, 57-66. https://doi.org/10.1016/j.nut.2016.12.003
Abdulrazaq M, Innes JK, Calder PC. Effect of Ω-3 Polyunsaturated Fatty Acids On Arthritic Pain: a Systematic Review. Nutrition. 2017 Jul - Aug;39-40:57-66. PubMed PMID: 28606571.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of ω-3 polyunsaturated fatty acids on arthritic pain: A systematic review. AU - Abdulrazaq,Mozghan, AU - Innes,Jacqueline K, AU - Calder,Philip C, Y1 - 2016/12/21/ PY - 2016/07/21/received PY - 2016/11/13/revised PY - 2016/12/02/accepted PY - 2017/6/14/entrez PY - 2017/6/14/pubmed PY - 2018/3/1/medline KW - DHA KW - EPA KW - Fish oil KW - Pain KW - Rheumatoid arthritis SP - 57 EP - 66 JF - Nutrition (Burbank, Los Angeles County, Calif.) JO - Nutrition VL - 39-40 N2 - OBJECTIVES: Pain is a significant problem in rheumatoid arthritis (RA) and is associated with prostaglandins derived from the ω-6 polyunsaturated fatty acid (PUFA) arachidonic acid. The ω-3 PUFAs eicosapentaenoic acid and docosahexaenoic acid have been shown to reduce inflammation, with some studies showing clinical improvements in RA. The aim of this systematic review was to investigate the effect of ω-3 PUFAs on arthritic pain. METHOD: A systematic literature review of ω-3 PUFAs and pain associated with RA was performed up to December 2015. Randomized controlled trials (RCTs) investigating the effect of ω-3 PUFAs (>2 g/d) on patient or physician assessment of pain, or assessment by both patient and physician, were included. The Cochrane Collaboration's tool for assessing risk for bias was employed. Data for outcomes of interest were extracted and collated for interpretation. RESULTS: Eighteen RCTs published between 1985 and 2013 involving 1143 patients were included. Dosage of ω-3 PUFAs used was 2.1 to 9.1 g/d, with study durations of 12 to 52 wk. Ten studies supported the hypothesis that there is a reduction in patient or physician assessment of pain associated with RA after intake of ω-3 PUFAs. Eight studies found no statistically significant effect of ω-3 PUFAs on arthritic pain. CONCLUSIONS: ω-3 PUFAs may have a therapeutic role in decreasing pain associated with RA, with doses of 3 to 6 g/d appearing to have a greater effect. Due to the limitations identified in the RCTs included in this review, more research is needed to investigate ω-3 PUFAs in larger populations and over extended periods of time. SN - 1873-1244 UR - https://www.unboundmedicine.com/medline/citation/28606571/Effect_of_ω_3_polyunsaturated_fatty_acids_on_arthritic_pain:_A_systematic_review_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0899-9007(16)30277-5 DB - PRIME DP - Unbound Medicine ER -