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Zika Virus: Recent Advances towards the Development of Vaccines and Therapeutics.
Viruses. 2017 06 13; 9(6)V

Abstract

Zika is a rapidly emerging public health threat. Although clinical infection is frequently mild, significant neurological manifestations have been demonstrated in infants born to Zika virus (ZIKV) infected mothers. Due to the substantial ramifications of intrauterine infection, effective counter-measures are urgently needed. In order to develop effective anti-ZIKV vaccines and therapeutics, improved animal models and a better understanding of immunological correlates of protection against ZIKV are required. This review will summarize what is currently known about ZIKV, the clinical manifestations and epidemiology of Zika as well as, the development of animal models to study ZIKV infection, host immune responses against ZIKV, and the current state of development of vaccines and therapeutics against ZIKV.

Authors+Show Affiliations

Center for Vaccine Development, University of Maryland School of Medicine, Baltimore, MD 21201, USA. mmcarthu@som.umaryland.edu.

Pub Type(s)

Journal Article
Review
Research Support, Non-U.S. Gov't
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

28608813

Citation

McArthur, Monica A.. "Zika Virus: Recent Advances Towards the Development of Vaccines and Therapeutics." Viruses, vol. 9, no. 6, 2017.
McArthur MA. Zika Virus: Recent Advances towards the Development of Vaccines and Therapeutics. Viruses. 2017;9(6).
McArthur, M. A. (2017). Zika Virus: Recent Advances towards the Development of Vaccines and Therapeutics. Viruses, 9(6). https://doi.org/10.3390/v9060143
McArthur MA. Zika Virus: Recent Advances Towards the Development of Vaccines and Therapeutics. Viruses. 2017 06 13;9(6) PubMed PMID: 28608813.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Zika Virus: Recent Advances towards the Development of Vaccines and Therapeutics. A1 - McArthur,Monica A, Y1 - 2017/06/13/ PY - 2017/04/18/received PY - 2017/06/02/revised PY - 2017/06/08/accepted PY - 2017/6/14/entrez PY - 2017/6/14/pubmed PY - 2018/3/1/medline KW - Zika virus KW - animal models KW - congenital Zika syndrome KW - immunology KW - vaccines JF - Viruses JO - Viruses VL - 9 IS - 6 N2 - Zika is a rapidly emerging public health threat. Although clinical infection is frequently mild, significant neurological manifestations have been demonstrated in infants born to Zika virus (ZIKV) infected mothers. Due to the substantial ramifications of intrauterine infection, effective counter-measures are urgently needed. In order to develop effective anti-ZIKV vaccines and therapeutics, improved animal models and a better understanding of immunological correlates of protection against ZIKV are required. This review will summarize what is currently known about ZIKV, the clinical manifestations and epidemiology of Zika as well as, the development of animal models to study ZIKV infection, host immune responses against ZIKV, and the current state of development of vaccines and therapeutics against ZIKV. SN - 1999-4915 UR - https://www.unboundmedicine.com/medline/citation/28608813/full_citation L2 - https://www.mdpi.com/resolver?pii=v9060143 DB - PRIME DP - Unbound Medicine ER -