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Spirometry Reference Equations from the HCHS/SOL (Hispanic Community Health Study/Study of Latinos).
Am J Respir Crit Care Med. 2017 10 15; 196(8):993-1003.AJ

Abstract

RATIONALE

Accurate reference values for spirometry are important because the results are used for diagnosing common chronic lung diseases such as asthma and chronic obstructive pulmonary disease, estimating physiologic impairment, and predicting all-cause mortality. Reference equations have been established for Mexican Americans but not for others with Hispanic/Latino backgrounds.

OBJECTIVES

To develop spirometry reference equations for adult Hispanic/Latino background groups in the United States.

METHODS

The HCHS/SOL (Hispanic Community Health Study/Study of Latinos) recruited a population-based probability sample of 16,415 Hispanics/Latinos aged 18-74 years living in the Bronx, Chicago, Miami, and San Diego. Participants self-identified as being of Puerto Rican, Cuban, Dominican, Mexican, or Central or South American background. Spirometry was performed using standardized methods with central quality control monitoring. Spirometric measures from a subset of 6,425 never-smoking participants without respiratory symptoms or disease were modeled as a function of sex, age, height, and Hispanic/Latino background to produce background-specific reference equations for the predicted value and lower limit of normal.

MEASUREMENTS AND MAIN RESULTS

Dominican and Puerto Rican Americans had substantially lower predicted and lower limit of normal values for FVC and FEV1 than those in other Hispanic/Latino background groups and also than Mexican American values from NHANES III (Third National Health and Nutrition Examination Survey).

CONCLUSIONS

For patients of Dominican and Puerto Rican background who present with pulmonary symptoms in clinical practice, use of background-specific spirometry reference equations may provide more appropriate predicted and lower limit of normal values, enabling more accurate diagnoses of abnormality and physiologic impairment.

Authors+Show Affiliations

1 Collaborative Studies Coordinating Center, Department of Biostatistics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.1 Collaborative Studies Coordinating Center, Department of Biostatistics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.2 Hankinson Consulting Inc., Athens, Georgia.3 University of Arizona, Tucson, Arizona.1 Collaborative Studies Coordinating Center, Department of Biostatistics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.4 Columbia University Medical Center, New York, New York.5 Albert Einstein College of Medicine, Bronx, New York.6 Northwestern University, Chicago, Illinois; and.7 San Diego State University, San Diego, California.1 Collaborative Studies Coordinating Center, Department of Biostatistics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.6 Northwestern University, Chicago, Illinois; and.7 San Diego State University, San Diego, California.

Pub Type(s)

Comparative Study
Journal Article
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

28613924

Citation

LaVange, Lisa, et al. "Spirometry Reference Equations From the HCHS/SOL (Hispanic Community Health Study/Study of Latinos)." American Journal of Respiratory and Critical Care Medicine, vol. 196, no. 8, 2017, pp. 993-1003.
LaVange L, Davis SM, Hankinson J, et al. Spirometry Reference Equations from the HCHS/SOL (Hispanic Community Health Study/Study of Latinos). Am J Respir Crit Care Med. 2017;196(8):993-1003.
LaVange, L., Davis, S. M., Hankinson, J., Enright, P., Wilson, R., Barr, R. G., Aldrich, T. K., Kalhan, R., Lemus, H., Ni, A., Smith, L. J., & Talavera, G. A. (2017). Spirometry Reference Equations from the HCHS/SOL (Hispanic Community Health Study/Study of Latinos). American Journal of Respiratory and Critical Care Medicine, 196(8), 993-1003. https://doi.org/10.1164/rccm.201610-1987OC
LaVange L, et al. Spirometry Reference Equations From the HCHS/SOL (Hispanic Community Health Study/Study of Latinos). Am J Respir Crit Care Med. 2017 10 15;196(8):993-1003. PubMed PMID: 28613924.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Spirometry Reference Equations from the HCHS/SOL (Hispanic Community Health Study/Study of Latinos). AU - LaVange,Lisa, AU - Davis,Sonia M, AU - Hankinson,John, AU - Enright,Paul, AU - Wilson,Rebbecca, AU - Barr,R Graham, AU - Aldrich,Thomas K, AU - Kalhan,Ravi, AU - Lemus,Hector, AU - Ni,Ai, AU - Smith,Lewis J, AU - Talavera,Gregory A, PY - 2017/6/15/pubmed PY - 2017/10/24/medline PY - 2017/6/15/entrez KW - Hispanic/Latino KW - reference standards KW - spirometry SP - 993 EP - 1003 JF - American journal of respiratory and critical care medicine JO - Am J Respir Crit Care Med VL - 196 IS - 8 N2 - RATIONALE: Accurate reference values for spirometry are important because the results are used for diagnosing common chronic lung diseases such as asthma and chronic obstructive pulmonary disease, estimating physiologic impairment, and predicting all-cause mortality. Reference equations have been established for Mexican Americans but not for others with Hispanic/Latino backgrounds. OBJECTIVES: To develop spirometry reference equations for adult Hispanic/Latino background groups in the United States. METHODS: The HCHS/SOL (Hispanic Community Health Study/Study of Latinos) recruited a population-based probability sample of 16,415 Hispanics/Latinos aged 18-74 years living in the Bronx, Chicago, Miami, and San Diego. Participants self-identified as being of Puerto Rican, Cuban, Dominican, Mexican, or Central or South American background. Spirometry was performed using standardized methods with central quality control monitoring. Spirometric measures from a subset of 6,425 never-smoking participants without respiratory symptoms or disease were modeled as a function of sex, age, height, and Hispanic/Latino background to produce background-specific reference equations for the predicted value and lower limit of normal. MEASUREMENTS AND MAIN RESULTS: Dominican and Puerto Rican Americans had substantially lower predicted and lower limit of normal values for FVC and FEV1 than those in other Hispanic/Latino background groups and also than Mexican American values from NHANES III (Third National Health and Nutrition Examination Survey). CONCLUSIONS: For patients of Dominican and Puerto Rican background who present with pulmonary symptoms in clinical practice, use of background-specific spirometry reference equations may provide more appropriate predicted and lower limit of normal values, enabling more accurate diagnoses of abnormality and physiologic impairment. SN - 1535-4970 UR - https://www.unboundmedicine.com/medline/citation/28613924/Spirometry_Reference_Equations_from_the_HCHS/SOL__Hispanic_Community_Health_Study/Study_of_Latinos__ L2 - https://www.atsjournals.org/doi/10.1164/rccm.201610-1987OC?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -