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The Hope and Hype of CRISPR-Cas9 Genome Editing: A Review.
JAMA Cardiol. 2017 08 01; 2(8):914-919.JC

Abstract

Importance

Clustered regularly interspaced short palindromic repeats (CRISPR) CRISPR-associated protein 9 (CRISPR-Cas9) has garnered a great degree of attention since its first reported uses in mammalian cells in early 2013 due to its perceived impact with respect to potential research applications and, especially, therapeutic applications.

Observations

CRISPR-Cas9 is being widely used in the laboratory and has greatly improved the ability to generate genetically modified animal models of human diseases. First steps have been reported with respect to proof-of-concept cardiovascular therapeutic applications in mouse models-which might eventually lead to new treatments for patients-as well as modification of human embryos, which raises a host of social, ethical, and legal questions.

Conclusions and Relevance

CRISPR-Cas9 is already having a substantial effect on cardiovascular basic science research. Although the first steps toward potential therapies have been taken, there are substantial obstacles that will need to be overcome if CRISPR-Cas9 is to be used in the practice of cardiovascular medicine.

Authors+Show Affiliations

Cardiovascular Institute, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia. Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

28614576

Citation

Musunuru, Kiran. "The Hope and Hype of CRISPR-Cas9 Genome Editing: a Review." JAMA Cardiology, vol. 2, no. 8, 2017, pp. 914-919.
Musunuru K. The Hope and Hype of CRISPR-Cas9 Genome Editing: A Review. JAMA Cardiol. 2017;2(8):914-919.
Musunuru, K. (2017). The Hope and Hype of CRISPR-Cas9 Genome Editing: A Review. JAMA Cardiology, 2(8), 914-919. https://doi.org/10.1001/jamacardio.2017.1713
Musunuru K. The Hope and Hype of CRISPR-Cas9 Genome Editing: a Review. JAMA Cardiol. 2017 08 1;2(8):914-919. PubMed PMID: 28614576.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The Hope and Hype of CRISPR-Cas9 Genome Editing: A Review. A1 - Musunuru,Kiran, PY - 2017/6/15/pubmed PY - 2019/6/4/medline PY - 2017/6/15/entrez SP - 914 EP - 919 JF - JAMA cardiology JO - JAMA Cardiol VL - 2 IS - 8 N2 - Importance: Clustered regularly interspaced short palindromic repeats (CRISPR) CRISPR-associated protein 9 (CRISPR-Cas9) has garnered a great degree of attention since its first reported uses in mammalian cells in early 2013 due to its perceived impact with respect to potential research applications and, especially, therapeutic applications. Observations: CRISPR-Cas9 is being widely used in the laboratory and has greatly improved the ability to generate genetically modified animal models of human diseases. First steps have been reported with respect to proof-of-concept cardiovascular therapeutic applications in mouse models-which might eventually lead to new treatments for patients-as well as modification of human embryos, which raises a host of social, ethical, and legal questions. Conclusions and Relevance: CRISPR-Cas9 is already having a substantial effect on cardiovascular basic science research. Although the first steps toward potential therapies have been taken, there are substantial obstacles that will need to be overcome if CRISPR-Cas9 is to be used in the practice of cardiovascular medicine. SN - 2380-6591 UR - https://www.unboundmedicine.com/medline/citation/28614576/The_Hope_and_Hype_of_CRISPR_Cas9_Genome_Editing:_A_Review_ L2 - https://jamanetwork.com/journals/jamacardiology/fullarticle/10.1001/jamacardio.2017.1713 DB - PRIME DP - Unbound Medicine ER -