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High-resolution transbulbar ultrasonography helping differentiate intracranial hypertension in bilateral optic disc oedema patients.
Acta Ophthalmol. 2017 Sep; 95(6):e481-e485.AO

Abstract

PURPOSE

The enlargement of optic nerve sheath diameter (ONSD) has been proven to be related with raised intracranial pressure (ICP). No prospective study has been focused on utilizing retrobulbar ultrasonography in optic disc oedema patient presented to ophthalmologist.

METHODS

High-resolution transbulbar ultrasonography was performed in a cohort of patient presented with bilateral optic disc oedema. The subarachnoid space of optic nerve (SAS), ONSD and optic nerve diameter (OND) was measured prior to other ancillaries including lumbar puncture. Subjects were classified into increased intracranial pressure (IIP) and normal intracranial pressure (NIP) group according to the open cerebrospinal fluid pressure more than 200 mm H2 0. The SAS, ONSD and OND were compared between groups and with normal control. The sensitivity of SAS or ONSD change for predicating intracranial hypertension was assessed.

RESULTS

A total of 20 IIP, 25 NIP patients and 25 normal controls were evaluated. The mean SAS and ONSD measured in idiopathic intracranial hypertension group was significantly increased than that of NIP and controls (p < 0.001), whereas the OND showed no statistic difference between each group. The sensitivities using the SAS and ONSD for differentiating increased ICP in optic disc oedema patients were 0.99 and 0.97, respectively.

CONCLUSIONS

The enlarged SAS and ONSD measured by high-resolution transbulbar sonography are very sensitive parameters to predicate increased ICP in bilateral optic disc oedema patients.

Authors+Show Affiliations

Department of Ophthalmology, Eye Ear Nose and Throat Hospital of Fudan University, Shanghai, China. State Key Laboratory of Medical Neurobiology, Institutes of Brain Science, Fudan University, Shanghai, China.Department of Neurology, Huashan Hospital, Fudan University, Shanghai, China.Department of Ophthalmology, Eye Ear Nose and Throat Hospital of Fudan University, Shanghai, China. State Key Laboratory of Medical Neurobiology, Institutes of Brain Science, Fudan University, Shanghai, China.Department of Ophthalmology, Eye Ear Nose and Throat Hospital of Fudan University, Shanghai, China. State Key Laboratory of Medical Neurobiology, Institutes of Brain Science, Fudan University, Shanghai, China.Department of Radiology, Eye Ear Nose and Throat Hospital of Fudan University, Shanghai, China.Department of Neurology, Huashan Hospital, Fudan University, Shanghai, China.Department of Ophthalmology, Eye Ear Nose and Throat Hospital of Fudan University, Shanghai, China. State Key Laboratory of Medical Neurobiology, Institutes of Brain Science, Fudan University, Shanghai, China.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

28616896

Citation

Chen, Qian, et al. "High-resolution Transbulbar Ultrasonography Helping Differentiate Intracranial Hypertension in Bilateral Optic Disc Oedema Patients." Acta Ophthalmologica, vol. 95, no. 6, 2017, pp. e481-e485.
Chen Q, Chen W, Wang M, et al. High-resolution transbulbar ultrasonography helping differentiate intracranial hypertension in bilateral optic disc oedema patients. Acta Ophthalmol. 2017;95(6):e481-e485.
Chen, Q., Chen, W., Wang, M., Sun, X., Sha, Y., Li, Z., & Tian, G. (2017). High-resolution transbulbar ultrasonography helping differentiate intracranial hypertension in bilateral optic disc oedema patients. Acta Ophthalmologica, 95(6), e481-e485. https://doi.org/10.1111/aos.13473
Chen Q, et al. High-resolution Transbulbar Ultrasonography Helping Differentiate Intracranial Hypertension in Bilateral Optic Disc Oedema Patients. Acta Ophthalmol. 2017;95(6):e481-e485. PubMed PMID: 28616896.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - High-resolution transbulbar ultrasonography helping differentiate intracranial hypertension in bilateral optic disc oedema patients. AU - Chen,Qian, AU - Chen,Weimin, AU - Wang,Min, AU - Sun,Xinghuai, AU - Sha,Yan, AU - Li,Zhenxin, AU - Tian,Guohong, Y1 - 2017/06/14/ PY - 2016/11/14/received PY - 2017/04/05/accepted PY - 2017/6/16/pubmed PY - 2017/11/29/medline PY - 2017/6/16/entrez KW - high-resolution ultrasonography KW - intracranial hypertension KW - optic disc oedema KW - optic nerve sheath diameter SP - e481 EP - e485 JF - Acta ophthalmologica JO - Acta Ophthalmol VL - 95 IS - 6 N2 - PURPOSE: The enlargement of optic nerve sheath diameter (ONSD) has been proven to be related with raised intracranial pressure (ICP). No prospective study has been focused on utilizing retrobulbar ultrasonography in optic disc oedema patient presented to ophthalmologist. METHODS: High-resolution transbulbar ultrasonography was performed in a cohort of patient presented with bilateral optic disc oedema. The subarachnoid space of optic nerve (SAS), ONSD and optic nerve diameter (OND) was measured prior to other ancillaries including lumbar puncture. Subjects were classified into increased intracranial pressure (IIP) and normal intracranial pressure (NIP) group according to the open cerebrospinal fluid pressure more than 200 mm H2 0. The SAS, ONSD and OND were compared between groups and with normal control. The sensitivity of SAS or ONSD change for predicating intracranial hypertension was assessed. RESULTS: A total of 20 IIP, 25 NIP patients and 25 normal controls were evaluated. The mean SAS and ONSD measured in idiopathic intracranial hypertension group was significantly increased than that of NIP and controls (p < 0.001), whereas the OND showed no statistic difference between each group. The sensitivities using the SAS and ONSD for differentiating increased ICP in optic disc oedema patients were 0.99 and 0.97, respectively. CONCLUSIONS: The enlarged SAS and ONSD measured by high-resolution transbulbar sonography are very sensitive parameters to predicate increased ICP in bilateral optic disc oedema patients. SN - 1755-3768 UR - https://www.unboundmedicine.com/medline/citation/28616896/High_resolution_transbulbar_ultrasonography_helping_differentiate_intracranial_hypertension_in_bilateral_optic_disc_oedema_patients_ L2 - https://doi.org/10.1111/aos.13473 DB - PRIME DP - Unbound Medicine ER -