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Structure and Biocompatibility of Bioabsorbable Nanocomposites of Aliphatic-Aromatic Copolyester and Cellulose Nanocrystals.
Biomacromolecules. 2017 Jul 10; 18(7):2179-2194.B

Abstract

Poly(butylene adipate-co-terephthalate) (PBAT) was first chemically modified via free radical grafting with maleic anhydride (MA) and the MA-g-PBAT graft copolymer was then used as a matrix material to obtain cellulose nanocrystal (CNC)-reinforced MA-g-PBAT bionanocomposites via reactive extrusion process to accelerate efforts to develop functional bioabsorbable polymer nanocomposites with improved properties. The molecular structure of the PBAT after chemical modification with maleic anhydride was confirmed by 1H NMR and FTIR spectroscopy. The morphological observation of the nanocomposites revealed that the CNCs were finely dispersed in the matrix. Thermal analysis of the hybrids showed an improvement of the thermal stability of the nanocomposites upon increasing the CNC content. In addition, it was found that the CNC nucleated crystallization of the PBAT in the nanocomposites. Extensive melt rheological characterization of the nanocomposite samples revealed a significant improvement of the viscoelastic properties of the matrix due to the strong interfacial adhesion of the CNC particles to the PBAT. Further, development of the nonterminal characteristics of the viscoelastic material functions and exhibition of yield stress were correlated with the evolution of a 3D-netowork nanostructure of CNCs in the matrix. This CNC nanostructure was interpreted in the framework of scaling theory of fractal elastic gels, and found to be consistent with the structure of open-porous flocs. Tensile testing of the samples showed considerable improvement in the modulus and ultimate strength of the samples with increasing the CNC content. In addition, a positive shift of the glass transition temperature was found in dynamic mechanical analysis. Finally, in vitro biocompatibility using Thiazolyl blue tetrazolium bromide (MTT) assay and cell adhesion studies with L929 fibroblast cells revealed no cytotoxic effect of CNCs, confirming the biocompatibility of the nanocomposites and the associated significant improvement of cell adhesion, suggesting the potential applicability of this nanocomposite in biomedical and tissue engineering applications.

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Publisher Full Text (DOI)

Authors+Show Affiliations

Kashani Rahimi S
School of Polymers and High Performance Materials, The University of Southern Mississippi , 118 College Drive, Hattiesburg, Mississippi, United States.
Aeinehvand R
Nano-Biopolymers Research Laboratory, Department of Chemical Engineering, College of Engineering, University of Tehran , P.O. Box 11155-4563, Tehran, Iran.
Kim K
School of Polymers and High Performance Materials, The University of Southern Mississippi , 118 College Drive, Hattiesburg, Mississippi, United States.
Otaigbe JU
School of Polymers and High Performance Materials, The University of Southern Mississippi , 118 College Drive, Hattiesburg, Mississippi, United States.

MeSH

AnimalsCell LineCelluloseFibroblastsMaterials TestingMiceNanocompositesNanoparticlesPolyesters

Pub Type(s)

Journal Article

Language

eng

PubMed ID

28616970

Citation

Kashani Rahimi, Shahab, et al. "Structure and Biocompatibility of Bioabsorbable Nanocomposites of Aliphatic-Aromatic Copolyester and Cellulose Nanocrystals." Biomacromolecules, vol. 18, no. 7, 2017, pp. 2179-2194.
Kashani Rahimi S, Aeinehvand R, Kim K, et al. Structure and Biocompatibility of Bioabsorbable Nanocomposites of Aliphatic-Aromatic Copolyester and Cellulose Nanocrystals. Biomacromolecules. 2017;18(7):2179-2194.
Kashani Rahimi, S., Aeinehvand, R., Kim, K., & Otaigbe, J. U. (2017). Structure and Biocompatibility of Bioabsorbable Nanocomposites of Aliphatic-Aromatic Copolyester and Cellulose Nanocrystals. Biomacromolecules, 18(7), 2179-2194. https://doi.org/10.1021/acs.biomac.7b00578
Kashani Rahimi S, et al. Structure and Biocompatibility of Bioabsorbable Nanocomposites of Aliphatic-Aromatic Copolyester and Cellulose Nanocrystals. Biomacromolecules. 2017 Jul 10;18(7):2179-2194. PubMed PMID: 28616970.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Structure and Biocompatibility of Bioabsorbable Nanocomposites of Aliphatic-Aromatic Copolyester and Cellulose Nanocrystals. AU - Kashani Rahimi,Shahab, AU - Aeinehvand,Robabeh, AU - Kim,Kyoungtae, AU - Otaigbe,Joshua U, Y1 - 2017/06/27/ PY - 2017/6/16/pubmed PY - 2018/4/3/medline PY - 2017/6/16/entrez SP - 2179 EP - 2194 JF - Biomacromolecules JO - Biomacromolecules VL - 18 IS - 7 N2 - Poly(butylene adipate-co-terephthalate) (PBAT) was first chemically modified via free radical grafting with maleic anhydride (MA) and the MA-g-PBAT graft copolymer was then used as a matrix material to obtain cellulose nanocrystal (CNC)-reinforced MA-g-PBAT bionanocomposites via reactive extrusion process to accelerate efforts to develop functional bioabsorbable polymer nanocomposites with improved properties. The molecular structure of the PBAT after chemical modification with maleic anhydride was confirmed by 1H NMR and FTIR spectroscopy. The morphological observation of the nanocomposites revealed that the CNCs were finely dispersed in the matrix. Thermal analysis of the hybrids showed an improvement of the thermal stability of the nanocomposites upon increasing the CNC content. In addition, it was found that the CNC nucleated crystallization of the PBAT in the nanocomposites. Extensive melt rheological characterization of the nanocomposite samples revealed a significant improvement of the viscoelastic properties of the matrix due to the strong interfacial adhesion of the CNC particles to the PBAT. Further, development of the nonterminal characteristics of the viscoelastic material functions and exhibition of yield stress were correlated with the evolution of a 3D-netowork nanostructure of CNCs in the matrix. This CNC nanostructure was interpreted in the framework of scaling theory of fractal elastic gels, and found to be consistent with the structure of open-porous flocs. Tensile testing of the samples showed considerable improvement in the modulus and ultimate strength of the samples with increasing the CNC content. In addition, a positive shift of the glass transition temperature was found in dynamic mechanical analysis. Finally, in vitro biocompatibility using Thiazolyl blue tetrazolium bromide (MTT) assay and cell adhesion studies with L929 fibroblast cells revealed no cytotoxic effect of CNCs, confirming the biocompatibility of the nanocomposites and the associated significant improvement of cell adhesion, suggesting the potential applicability of this nanocomposite in biomedical and tissue engineering applications. SN - 1526-4602 UR - https://www.unboundmedicine.com/medline/citation/28616970/Structure_and_Biocompatibility_of_Bioabsorbable_Nanocomposites_of_Aliphatic_Aromatic_Copolyester_and_Cellulose_Nanocrystals_ L2 - https://doi.org/10.1021/acs.biomac.7b00578 DB - PRIME DP - Unbound Medicine ER -