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Major hereditary gastrointestinal cancer syndromes: a narrative review.
J Gastrointestin Liver Dis. 2017 Jun; 26(2):157-163.JG

Abstract

Gastrointestinal cancer is one of the major causes of death worldwide. Hereditary gastrointestinal cancer syndromes constitute about 5-10% of all cancers. About 20-25% of undiagnosed cases have a possible hereditary component, which is not yet established. In the last few decades, the advance in genomics has led to the discovery of multiple cancer predisposition genes in gastrointestinal cancer. Physicians should be aware of these syndromes to identify high-risk patients and offer genetic testing to prevent cancer death. In this review, we describe clinical manifestations, genetic testing and its challenges, diagnosis and management of the major hereditary gastrointestinal cancer syndromes.

Authors+Show Affiliations

Creighton University Medical Center, Omaha, NE, USA. lakshmimanognachintalacheruvu@creighton.edu.Creighton University School of Medicine, Omaha, NE, USA.Creighton University Medical Center, Omaha, NE, USA.Creighton University Medical Center, Omaha, NE, USA.Creighton University Medical Center, Omaha, NE, USA.Creighton University Medical Center, Omaha, NE, USA.Creighton University Medical Center, Omaha, NE, USA.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

28617886

Citation

Chintalacheruvu, Lakshmi Manogna, et al. "Major Hereditary Gastrointestinal Cancer Syndromes: a Narrative Review." Journal of Gastrointestinal and Liver Diseases : JGLD, vol. 26, no. 2, 2017, pp. 157-163.
Chintalacheruvu LM, Shaw T, Buddam A, et al. Major hereditary gastrointestinal cancer syndromes: a narrative review. J Gastrointestin Liver Dis. 2017;26(2):157-163.
Chintalacheruvu, L. M., Shaw, T., Buddam, A., Diab, O., Kassim, T., Mukherjee, S., & Lynch, H. T. (2017). Major hereditary gastrointestinal cancer syndromes: a narrative review. Journal of Gastrointestinal and Liver Diseases : JGLD, 26(2), 157-163. https://doi.org/10.15403/jgld.2014.1121.262.maj
Chintalacheruvu LM, et al. Major Hereditary Gastrointestinal Cancer Syndromes: a Narrative Review. J Gastrointestin Liver Dis. 2017;26(2):157-163. PubMed PMID: 28617886.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Major hereditary gastrointestinal cancer syndromes: a narrative review. AU - Chintalacheruvu,Lakshmi Manogna, AU - Shaw,Trudy, AU - Buddam,Avanija, AU - Diab,Osama, AU - Kassim,Thamer, AU - Mukherjee,Sandeep, AU - Lynch,Henry T, PY - 2017/6/16/entrez PY - 2017/6/16/pubmed PY - 2018/4/3/medline SP - 157 EP - 163 JF - Journal of gastrointestinal and liver diseases : JGLD JO - J Gastrointestin Liver Dis VL - 26 IS - 2 N2 - Gastrointestinal cancer is one of the major causes of death worldwide. Hereditary gastrointestinal cancer syndromes constitute about 5-10% of all cancers. About 20-25% of undiagnosed cases have a possible hereditary component, which is not yet established. In the last few decades, the advance in genomics has led to the discovery of multiple cancer predisposition genes in gastrointestinal cancer. Physicians should be aware of these syndromes to identify high-risk patients and offer genetic testing to prevent cancer death. In this review, we describe clinical manifestations, genetic testing and its challenges, diagnosis and management of the major hereditary gastrointestinal cancer syndromes. SN - 1842-1121 UR - https://www.unboundmedicine.com/medline/citation/28617886/Major_hereditary_gastrointestinal_cancer_syndromes:_a_narrative_review_ L2 - http://dx.doi.org/10.15403/jgld.2014.1121.262.maj DB - PRIME DP - Unbound Medicine ER -