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The effects of the Lactobacillus casei strain on obesity in children: a pilot study.
Benef Microbes. 2017 Aug 24; 8(4):535-543.BM

Abstract

There are few data regarding the role of probiotics as a dietary intervention in the management of obesity in children. An open prospective examination was conducted to clarify the effects of Lactobacillus casei strain Shirota (LcS)-containing beverages in obese children. We compared the intestinal microbiota and organic acid levels between 12 obese (average age, 10.8 years; body mass index (BMI) Z score, 2.7±1.7) and 22 control children(average age, 8.5 years; BMI Z score, 0.1±0.7), and pre- and post-intervention in the obese children. The obese group underwent diet and exercise therapy for 6 months and then were given an LcS beverage daily for another 6 months and the body weight and serological markers were monitored. Significant reductions in the faecal concentrations of Bifidobacterium (obese group, 7.9±1.5 vs non-obese group, 9.8±0.5 Log10cells/g; P<0.01) along with a significant decline in the Bacteroides fragilis group, Atopobium cluster and Lactobacillus gasseri subgroup, and acetic acid (obese group, 45.1±16.9 vs non-obese group, 57.9±17.6 μmol/g; P<0.05) were observed in the obese group at baseline. A significant decline in body weight (-2.9±4.6%; P<0.05) and an elevation in the high density lipoprotein cholesterol level (+11.1±17.6%; P<0.05) were observed 6 months after ingestion of the LcS beverage compared to baseline. Furthermore, a significant increase in the faecal concentration of Bifidobacterium (7.0±1.2 before ingestion vs 9.1±1.2 Log10cells/g after ingestion; P<0.01) and an apparent increase in the acetic acid concentration (7.0±1.2 before ingestion vs 9.1±1.2 Log10cells/g after ingestion; P<0.01) were observed 6 months after ingestion. LcS contributed to weight loss while also improving the lipid metabolism in obese children via a significant increase in the faecal Bifidobacterium numbers and the acetic acid concentration.

Authors+Show Affiliations

1 Department of Paediatrics, School of Medicine, Tokyo Women's Medical University, 8-1, Kawada-cho, Shinjuku-ku, Tokyo 162-8666, Japan. 2 Probiotics Research Laboratory, Juntendo University Postgraduate School, 3rd floor, 2-9-8 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.1 Department of Paediatrics, School of Medicine, Tokyo Women's Medical University, 8-1, Kawada-cho, Shinjuku-ku, Tokyo 162-8666, Japan. 2 Probiotics Research Laboratory, Juntendo University Postgraduate School, 3rd floor, 2-9-8 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.2 Probiotics Research Laboratory, Juntendo University Postgraduate School, 3rd floor, 2-9-8 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.2 Probiotics Research Laboratory, Juntendo University Postgraduate School, 3rd floor, 2-9-8 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.

Pub Type(s)

Clinical Trial
Journal Article

Language

eng

PubMed ID

28618860

Citation

Nagata, S, et al. "The Effects of the Lactobacillus Casei Strain On Obesity in Children: a Pilot Study." Beneficial Microbes, vol. 8, no. 4, 2017, pp. 535-543.
Nagata S, Chiba Y, Wang C, et al. The effects of the Lactobacillus casei strain on obesity in children: a pilot study. Benef Microbes. 2017;8(4):535-543.
Nagata, S., Chiba, Y., Wang, C., & Yamashiro, Y. (2017). The effects of the Lactobacillus casei strain on obesity in children: a pilot study. Beneficial Microbes, 8(4), 535-543. https://doi.org/10.3920/BM2016.0170
Nagata S, et al. The Effects of the Lactobacillus Casei Strain On Obesity in Children: a Pilot Study. Benef Microbes. 2017 Aug 24;8(4):535-543. PubMed PMID: 28618860.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The effects of the Lactobacillus casei strain on obesity in children: a pilot study. AU - Nagata,S, AU - Chiba,Y, AU - Wang,C, AU - Yamashiro,Y, Y1 - 2017/06/16/ PY - 2017/6/18/pubmed PY - 2018/4/18/medline PY - 2017/6/17/entrez KW - Bifidobacterium KW - Lactobacillus casei KW - acetic acid KW - children KW - obesity SP - 535 EP - 543 JF - Beneficial microbes JO - Benef Microbes VL - 8 IS - 4 N2 - There are few data regarding the role of probiotics as a dietary intervention in the management of obesity in children. An open prospective examination was conducted to clarify the effects of Lactobacillus casei strain Shirota (LcS)-containing beverages in obese children. We compared the intestinal microbiota and organic acid levels between 12 obese (average age, 10.8 years; body mass index (BMI) Z score, 2.7±1.7) and 22 control children(average age, 8.5 years; BMI Z score, 0.1±0.7), and pre- and post-intervention in the obese children. The obese group underwent diet and exercise therapy for 6 months and then were given an LcS beverage daily for another 6 months and the body weight and serological markers were monitored. Significant reductions in the faecal concentrations of Bifidobacterium (obese group, 7.9±1.5 vs non-obese group, 9.8±0.5 Log10cells/g; P<0.01) along with a significant decline in the Bacteroides fragilis group, Atopobium cluster and Lactobacillus gasseri subgroup, and acetic acid (obese group, 45.1±16.9 vs non-obese group, 57.9±17.6 μmol/g; P<0.05) were observed in the obese group at baseline. A significant decline in body weight (-2.9±4.6%; P<0.05) and an elevation in the high density lipoprotein cholesterol level (+11.1±17.6%; P<0.05) were observed 6 months after ingestion of the LcS beverage compared to baseline. Furthermore, a significant increase in the faecal concentration of Bifidobacterium (7.0±1.2 before ingestion vs 9.1±1.2 Log10cells/g after ingestion; P<0.01) and an apparent increase in the acetic acid concentration (7.0±1.2 before ingestion vs 9.1±1.2 Log10cells/g after ingestion; P<0.01) were observed 6 months after ingestion. LcS contributed to weight loss while also improving the lipid metabolism in obese children via a significant increase in the faecal Bifidobacterium numbers and the acetic acid concentration. SN - 1876-2891 UR - https://www.unboundmedicine.com/medline/citation/28618860/The_effects_of_the_Lactobacillus_casei_strain_on_obesity_in_children:_a_pilot_study_ L2 - https://www.wageningenacademic.com/doi/10.3920/BM2016.0170?url_ver=Z39.88-2003&amp;rfr_id=ori:rid:crossref.org&amp;rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -