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Polycystic ovary syndrome and risk of endometrial, ovarian, and breast cancer: a systematic review.
Fertil Res Pract 2016; 2:14FR

Abstract

BACKGROUND

Polycystic ovary syndrome (PCOS) is a complex endocrine disorder with an estimated prevalence of 4-21% in reproductive aged women. The altered metabolic and hormonal environment among women with PCOS may increase their risk of some types of cancer.

METHODS

We performed a comprehensive review of the literature using numerous search terms for all studies examining the associations between polycystic ovary syndrome and related characteristics and cancer published in English through October 2016. This review summarizes the epidemiological findings on the associations between PCOS and endometrial, ovarian, and breast cancers and discusses the methodological issues, complexities, and underlying mechanisms of these associations.

RESULTS

We identified 11 individual studies and 3 meta-analyses on the associations between PCOS and endometrial cancer, 8 studies and 1 meta-analysis for ovarian cancer, and 10 studies and 1 meta-analysis for breast cancer. Multiple studies reported that women with PCOS were at a higher risk for endometrial cancer; however, many did not take into account body mass index (BMI), a strong and well-established risk factor for endometrial cancer. The association with ovarian cancer was less clear, but a potentially increased risk of the borderline serous subtype was reported by two studies. No consistent association between PCOS risk and breast cancer was observed.

CONCLUSION

The associations between PCOS and endometrial, ovarian, and breast cancer are complex, with the need to consider many methodological issues in future analyses. Larger well-designed studies, or pooled analyses, may help clarify these complex associations.

Authors+Show Affiliations

Program in Epidemiology, Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, M4-859 Seattle, WA USA. Department of Obstetrics and Gynecology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA USA.Department of Obstetrics and Gynecology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA USA. Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA USA.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

28620541

Citation

Harris, Holly R., and Kathryn L. Terry. "Polycystic Ovary Syndrome and Risk of Endometrial, Ovarian, and Breast Cancer: a Systematic Review." Fertility Research and Practice, vol. 2, 2016, p. 14.
Harris HR, Terry KL. Polycystic ovary syndrome and risk of endometrial, ovarian, and breast cancer: a systematic review. Fertil Res Pract. 2016;2:14.
Harris, H. R., & Terry, K. L. (2016). Polycystic ovary syndrome and risk of endometrial, ovarian, and breast cancer: a systematic review. Fertility Research and Practice, 2, p. 14. doi:10.1186/s40738-016-0029-2.
Harris HR, Terry KL. Polycystic Ovary Syndrome and Risk of Endometrial, Ovarian, and Breast Cancer: a Systematic Review. Fertil Res Pract. 2016;2:14. PubMed PMID: 28620541.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Polycystic ovary syndrome and risk of endometrial, ovarian, and breast cancer: a systematic review. AU - Harris,Holly R, AU - Terry,Kathryn L, Y1 - 2016/12/05/ PY - 2016/08/20/received PY - 2016/11/25/accepted PY - 2017/6/17/entrez PY - 2017/6/18/pubmed PY - 2017/6/18/medline KW - Breast cancer KW - Endometrial cancer KW - Ovarian cancer KW - Polycystic ovary syndrome SP - 14 EP - 14 JF - Fertility research and practice JO - Fertil Res Pract VL - 2 N2 - BACKGROUND: Polycystic ovary syndrome (PCOS) is a complex endocrine disorder with an estimated prevalence of 4-21% in reproductive aged women. The altered metabolic and hormonal environment among women with PCOS may increase their risk of some types of cancer. METHODS: We performed a comprehensive review of the literature using numerous search terms for all studies examining the associations between polycystic ovary syndrome and related characteristics and cancer published in English through October 2016. This review summarizes the epidemiological findings on the associations between PCOS and endometrial, ovarian, and breast cancers and discusses the methodological issues, complexities, and underlying mechanisms of these associations. RESULTS: We identified 11 individual studies and 3 meta-analyses on the associations between PCOS and endometrial cancer, 8 studies and 1 meta-analysis for ovarian cancer, and 10 studies and 1 meta-analysis for breast cancer. Multiple studies reported that women with PCOS were at a higher risk for endometrial cancer; however, many did not take into account body mass index (BMI), a strong and well-established risk factor for endometrial cancer. The association with ovarian cancer was less clear, but a potentially increased risk of the borderline serous subtype was reported by two studies. No consistent association between PCOS risk and breast cancer was observed. CONCLUSION: The associations between PCOS and endometrial, ovarian, and breast cancer are complex, with the need to consider many methodological issues in future analyses. Larger well-designed studies, or pooled analyses, may help clarify these complex associations. SN - 2054-7099 UR - https://www.unboundmedicine.com/medline/citation/28620541/Polycystic_ovary_syndrome_and_risk_of_endometrial_ovarian_and_breast_cancer:_a_systematic_review_ L2 - https://fertilityresearchandpractice.biomedcentral.com/articles/10.1186/s40738-016-0029-2 DB - PRIME DP - Unbound Medicine ER -