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Agranulocytosis in the course of phenothiazine therapy: case reports.
J Clin Psychiatry. 1985 Aug; 46(8):341-3.JC

Abstract

Agranulocytosis developed in three patients subsequent to chlorpromazine therapy and in one patient following treatment with methotrimeprazine and trifluoperazine. Although three of these four patients developed agranulocytosis within the expected time lapse (6 weeks), one patient developed the condition 12 years after the initiation of therapy. In one patient there was a recurrence of the agranulocytosis following reinstitution of chlorpromazine therapy. The subsequent treatment of psychosis is safer if another neuroleptic is substituted for the one that caused the agranulocytosis.

Authors

Yassa R
No affiliation info available

MeSH

AdultAgranulocytosisAntipsychotic AgentsChlorpromazineFemaleHumansMaleMiddle AgedPsychotic DisordersSchizophreniaSchizophrenia, Paranoid

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

2862136

Citation

Yassa, R. "Agranulocytosis in the Course of Phenothiazine Therapy: Case Reports." The Journal of Clinical Psychiatry, vol. 46, no. 8, 1985, pp. 341-3.
Yassa R. Agranulocytosis in the course of phenothiazine therapy: case reports. J Clin Psychiatry. 1985;46(8):341-3.
Yassa, R. (1985). Agranulocytosis in the course of phenothiazine therapy: case reports. The Journal of Clinical Psychiatry, 46(8), 341-3.
Yassa R. Agranulocytosis in the Course of Phenothiazine Therapy: Case Reports. J Clin Psychiatry. 1985;46(8):341-3. PubMed PMID: 2862136.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Agranulocytosis in the course of phenothiazine therapy: case reports. A1 - Yassa,R, PY - 1985/8/1/pubmed PY - 1985/8/1/medline PY - 1985/8/1/entrez SP - 341 EP - 3 JF - The Journal of clinical psychiatry JO - J Clin Psychiatry VL - 46 IS - 8 N2 - Agranulocytosis developed in three patients subsequent to chlorpromazine therapy and in one patient following treatment with methotrimeprazine and trifluoperazine. Although three of these four patients developed agranulocytosis within the expected time lapse (6 weeks), one patient developed the condition 12 years after the initiation of therapy. In one patient there was a recurrence of the agranulocytosis following reinstitution of chlorpromazine therapy. The subsequent treatment of psychosis is safer if another neuroleptic is substituted for the one that caused the agranulocytosis. SN - 0160-6689 UR - https://www.unboundmedicine.com/medline/citation/2862136/Agranulocytosis_in_the_course_of_phenothiazine_therapy:_case_reports_ DB - PRIME DP - Unbound Medicine ER -