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Diagnosis and phylogenetic analysis of a multifocal cutaneous orf virus with mixed bacterial infection outbreak in goats in Fujian province, China.
Arch Virol 2017; 162(10):2997-3006AV

Abstract

Outbreaks of orf virus on goat farms are common in China. In this study, we investigated a severe multifocal cutaneous orf virus outbreak with a correlative mixed bacterial infection which persisted for up to 6 months, and which had a high morbidity (93.7%) and mortality (15%) among kids in a herd of crossbreed goats in Fujian province in China. The disease was diagnosed as an orf virus (ORFV XD strain) infection associating with Streptococcus pluranimalium and Staphylococcus, identified using standard virological and bacteriological techniques. Multiple sequence alignments and phylogenetic analyses of the whole ORFV 011 (B2L), 059 (F1L), 032 and 080 genes revealed that the even though the virus phylogeny was clustered in branches of conventional orf virus strains, it nonetheless evidenced high variation within this subset. Furthermore, the sequences from the ORFV 080 gene allowed us to distinguish between the different strains at a higher resolution and these observations afforded us a comparative view of the ORFV 080 gene. This is the first report describing an outbreak of severe multifocal cutaneous orf virus with associated bacterial infection in China.

Authors+Show Affiliations

College of Animal Sciences, Fujian Agriculture and Forestry University, Fuzhou, 350002, Fujian, People's Republic of China.College of Animal Sciences, Fujian Agriculture and Forestry University, Fuzhou, 350002, Fujian, People's Republic of China. zxc206@163.com.Department of Laboratory Medicine, School of Stomatology and Medicine, Foshan University, Foshan, 528000, Guangdong, People's Republic of China.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

28623407

Citation

Chi, Xuelin, et al. "Diagnosis and Phylogenetic Analysis of a Multifocal Cutaneous Orf Virus With Mixed Bacterial Infection Outbreak in Goats in Fujian Province, China." Archives of Virology, vol. 162, no. 10, 2017, pp. 2997-3006.
Chi X, Zeng X, Luo S. Diagnosis and phylogenetic analysis of a multifocal cutaneous orf virus with mixed bacterial infection outbreak in goats in Fujian province, China. Arch Virol. 2017;162(10):2997-3006.
Chi, X., Zeng, X., & Luo, S. (2017). Diagnosis and phylogenetic analysis of a multifocal cutaneous orf virus with mixed bacterial infection outbreak in goats in Fujian province, China. Archives of Virology, 162(10), pp. 2997-3006. doi:10.1007/s00705-017-3424-z.
Chi X, Zeng X, Luo S. Diagnosis and Phylogenetic Analysis of a Multifocal Cutaneous Orf Virus With Mixed Bacterial Infection Outbreak in Goats in Fujian Province, China. Arch Virol. 2017;162(10):2997-3006. PubMed PMID: 28623407.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Diagnosis and phylogenetic analysis of a multifocal cutaneous orf virus with mixed bacterial infection outbreak in goats in Fujian province, China. AU - Chi,Xuelin, AU - Zeng,Xiancheng, AU - Luo,Shuhong, Y1 - 2017/06/16/ PY - 2016/09/09/received PY - 2017/04/27/accepted PY - 2017/6/18/pubmed PY - 2018/4/3/medline PY - 2017/6/18/entrez SP - 2997 EP - 3006 JF - Archives of virology JO - Arch. Virol. VL - 162 IS - 10 N2 - Outbreaks of orf virus on goat farms are common in China. In this study, we investigated a severe multifocal cutaneous orf virus outbreak with a correlative mixed bacterial infection which persisted for up to 6 months, and which had a high morbidity (93.7%) and mortality (15%) among kids in a herd of crossbreed goats in Fujian province in China. The disease was diagnosed as an orf virus (ORFV XD strain) infection associating with Streptococcus pluranimalium and Staphylococcus, identified using standard virological and bacteriological techniques. Multiple sequence alignments and phylogenetic analyses of the whole ORFV 011 (B2L), 059 (F1L), 032 and 080 genes revealed that the even though the virus phylogeny was clustered in branches of conventional orf virus strains, it nonetheless evidenced high variation within this subset. Furthermore, the sequences from the ORFV 080 gene allowed us to distinguish between the different strains at a higher resolution and these observations afforded us a comparative view of the ORFV 080 gene. This is the first report describing an outbreak of severe multifocal cutaneous orf virus with associated bacterial infection in China. SN - 1432-8798 UR - https://www.unboundmedicine.com/medline/citation/28623407/Diagnosis_and_phylogenetic_analysis_of_a_multifocal_cutaneous_orf_virus_with_mixed_bacterial_infection_outbreak_in_goats_in_Fujian_province_China_ L2 - https://dx.doi.org/10.1007/s00705-017-3424-z DB - PRIME DP - Unbound Medicine ER -