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Effect of chronic arsenic exposure under environmental conditions on bioaccumulation, oxidative stress, and antioxidant enzymatic defenses in wild trout Salmo trutta (Pisces, Teleostei).
Ecotoxicology. 2017 Sep; 26(7):930-941.E

Abstract

The present study evaluates the relation between chronic arsenic (As) exposure in the natural distribution area of wild brown trout (Salmo trutta), oxidative stress and antioxidant enzymatic defenses. Two rivers of the same watershed were evaluated to highlight the correlation between As accumulation and the resulting stress: (i) the Presa River, which has high chronic As levels (2281.66 µg/L) due to past mining activity, and (ii) the Bravona River (control river). This metalloid was measured in main fish tissues (gills, kidney, liver, muscle, gonads and fins) and water. As organotropism in S. trutta was kidney > liver > gill > fin > gonad > muscle. The HepatoSomatic Index (HSI) and somatic condition (CF) were used to compare fish population conditions from both sites. Arsenic can be absorbed by the gills and can induce oxidative stress and disturb antioxidant defenses. The aim of this study was to evaluate oxidative stress response by measuring malondialdehyde (MDA) content, as a marker of lipid peroxidation, and antioxidant enzymatic defenses (Superoxide dismutase (SOD), catalase CAT, glutathione peroxidase (GPx) and glutathione S-transferase (GST)), in the main tissues of control and exposed trout. The highest MDA content was found in the kidney and liver of exposed trout. SOD and CAT activities in exposed livers and kidneys were considerably increased while a significant rise of GPx activity was observed only in the liver. GST activity was found to be significantly induced in the liver of exposed trout. The results demonstrate that arsenic bioaccumulation can induce lipid peroxidation and substantial modifications in antioxidant enzymatic defenses in main wild trout tissues.

Authors+Show Affiliations

Laboratoire Parasites et Ecosystèmes méditerranéens, UMR CNRS 6134 SPE, Università di Corsica, F-20250, Corti, Corsica, France.Laboratoire de Biochimie et Biologie moléculaire du végétal, UMR CNRS 6134 SPE, Università di Corsica, F-20250, Corti, Corsica, France.Laboratoire de Biochimie et Biologie moléculaire du végétal, UMR CNRS 6134 SPE, Università di Corsica, F-20250, Corti, Corsica, France.Laboratoire Parasites et Ecosystèmes méditerranéens, UMR CNRS 6134 SPE, Università di Corsica, F-20250, Corti, Corsica, France.Laboratoire de Biochimie et Biologie moléculaire du végétal, UMR CNRS 6134 SPE, Università di Corsica, F-20250, Corti, Corsica, France.Laboratoire de Biochimie et Biologie moléculaire du végétal, UMR CNRS 6134 SPE, Università di Corsica, F-20250, Corti, Corsica, France. jeremie.santini@univ-corse.fr.Laboratoire Parasites et Ecosystèmes méditerranéens, UMR CNRS 6134 SPE, Università di Corsica, F-20250, Corti, Corsica, France.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

28623431

Citation

Greani, Samuel, et al. "Effect of Chronic Arsenic Exposure Under Environmental Conditions On Bioaccumulation, Oxidative Stress, and Antioxidant Enzymatic Defenses in Wild Trout Salmo Trutta (Pisces, Teleostei)." Ecotoxicology (London, England), vol. 26, no. 7, 2017, pp. 930-941.
Greani S, Lourkisti R, Berti L, et al. Effect of chronic arsenic exposure under environmental conditions on bioaccumulation, oxidative stress, and antioxidant enzymatic defenses in wild trout Salmo trutta (Pisces, Teleostei). Ecotoxicology. 2017;26(7):930-941.
Greani, S., Lourkisti, R., Berti, L., Marchand, B., Giannettini, J., Santini, J., & Quilichini, Y. (2017). Effect of chronic arsenic exposure under environmental conditions on bioaccumulation, oxidative stress, and antioxidant enzymatic defenses in wild trout Salmo trutta (Pisces, Teleostei). Ecotoxicology (London, England), 26(7), 930-941. https://doi.org/10.1007/s10646-017-1822-3
Greani S, et al. Effect of Chronic Arsenic Exposure Under Environmental Conditions On Bioaccumulation, Oxidative Stress, and Antioxidant Enzymatic Defenses in Wild Trout Salmo Trutta (Pisces, Teleostei). Ecotoxicology. 2017;26(7):930-941. PubMed PMID: 28623431.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of chronic arsenic exposure under environmental conditions on bioaccumulation, oxidative stress, and antioxidant enzymatic defenses in wild trout Salmo trutta (Pisces, Teleostei). AU - Greani,Samuel, AU - Lourkisti,Radia, AU - Berti,Liliane, AU - Marchand,Bernard, AU - Giannettini,Jean, AU - Santini,Jérémie, AU - Quilichini,Yann, Y1 - 2017/06/16/ PY - 2017/05/30/accepted PY - 2017/6/18/pubmed PY - 2017/12/16/medline PY - 2017/6/18/entrez KW - Antioxidant defenses KW - Arsenic KW - Bioaccumulation KW - Oxidative stress KW - Salmo trutta KW - Wild trout SP - 930 EP - 941 JF - Ecotoxicology (London, England) JO - Ecotoxicology VL - 26 IS - 7 N2 - The present study evaluates the relation between chronic arsenic (As) exposure in the natural distribution area of wild brown trout (Salmo trutta), oxidative stress and antioxidant enzymatic defenses. Two rivers of the same watershed were evaluated to highlight the correlation between As accumulation and the resulting stress: (i) the Presa River, which has high chronic As levels (2281.66 µg/L) due to past mining activity, and (ii) the Bravona River (control river). This metalloid was measured in main fish tissues (gills, kidney, liver, muscle, gonads and fins) and water. As organotropism in S. trutta was kidney > liver > gill > fin > gonad > muscle. The HepatoSomatic Index (HSI) and somatic condition (CF) were used to compare fish population conditions from both sites. Arsenic can be absorbed by the gills and can induce oxidative stress and disturb antioxidant defenses. The aim of this study was to evaluate oxidative stress response by measuring malondialdehyde (MDA) content, as a marker of lipid peroxidation, and antioxidant enzymatic defenses (Superoxide dismutase (SOD), catalase CAT, glutathione peroxidase (GPx) and glutathione S-transferase (GST)), in the main tissues of control and exposed trout. The highest MDA content was found in the kidney and liver of exposed trout. SOD and CAT activities in exposed livers and kidneys were considerably increased while a significant rise of GPx activity was observed only in the liver. GST activity was found to be significantly induced in the liver of exposed trout. The results demonstrate that arsenic bioaccumulation can induce lipid peroxidation and substantial modifications in antioxidant enzymatic defenses in main wild trout tissues. SN - 1573-3017 UR - https://www.unboundmedicine.com/medline/citation/28623431/Effect_of_chronic_arsenic_exposure_under_environmental_conditions_on_bioaccumulation_oxidative_stress_and_antioxidant_enzymatic_defenses_in_wild_trout_Salmo_trutta__Pisces_Teleostei__ L2 - https://doi.org/10.1007/s10646-017-1822-3 DB - PRIME DP - Unbound Medicine ER -