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Low serum diamine oxidase (DAO) activity levels in patients with migraine.
J Physiol Biochem. 2018 Feb; 74(1):93-99.JP

Abstract

Histamine intolerance is a disorder in the homeostasis of histamine due to a reduced intestinal degradation of this amine, mainly caused by a deficiency in the enzyme diamine oxidase (DAO). Among the several multi-faced symptoms associated with histamine intolerance, headache is one of the most recognized and disabling consequences. The aim of this study was to determine the prevalence of DAO deficiency in patients with a confirmed migraine diagnosis according to the current International Headache Society (IHS) and in non-migraine subjects. DAO activity was assessed in a total of 198 volunteers recruited at the Headache Unit of the Hospital General de Catalunya, 137 in the migraine group and 61 as a control group. DAO enzyme activity in blood samples was determined by ELISA test. Values below 80 HDU/ml (Histamine Degrading Unit/ml) were considered as DAO deficient. Mean value of DAO activity from migraine population (64.5 ± 33.5 HDU/ml) was significantly lower (p < 0.0001) than that obtained from healthy volunteers (91.9 ± 44.3 HDU/ml). DAO deficiency was more prevalent in migraine patients than in the control group. A high incidence rate of DAO deficiency (87%) was observed in the group of patients with migraine. On the other hand, 44% of non-migranous subjects had levels of DAO activity lower than 80 HDU/ml. Despite the multifactorial aetiology of migraine, these results seem to indicate that this enzymatic deficit could be related to the onset of migraine.

Authors+Show Affiliations

Department of Neurology, Hospital General de Catalunya, C/ Pere i Pons 1, 08915, Sant Cugat del Vallès, Spain. Department of Basic Sciences, Universitat Internacional de Catalunya, C/ Pere i Pons 1, 08915, Sant Cugat del Vallès, Spain.Department of Nutrition, Food Sciences and Gastronomy, XaRTA, INSA, School of Pharmacy and Food Sciences, University of Barcelona, Avinguda Prat de la Riba 171, 08921, Santa Coloma de Gramenet, Spain.Department of Nutrition, Food Sciences and Gastronomy, XaRTA, INSA, School of Pharmacy and Food Sciences, University of Barcelona, Avinguda Prat de la Riba 171, 08921, Santa Coloma de Gramenet, Spain.Department of Basic Sciences, Universitat Internacional de Catalunya, C/ Pere i Pons 1, 08915, Sant Cugat del Vallès, Spain.Department of Nutrition, Instituto Clínico del Déficit de DAO (ICDDAO), C/ Pere i Pons 1, 08195, Sant Cugat del Vallès, Spain.Department of Nutrition, Food Sciences and Gastronomy, XaRTA, INSA, School of Pharmacy and Food Sciences, University of Barcelona, Avinguda Prat de la Riba 171, 08921, Santa Coloma de Gramenet, Spain. mcvidal@ub.edu.Department of Neurology, Hospital General de Catalunya, C/ Pere i Pons 1, 08915, Sant Cugat del Vallès, Spain. Department of Basic Sciences, Universitat Internacional de Catalunya, C/ Pere i Pons 1, 08915, Sant Cugat del Vallès, Spain.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

28624934

Citation

Izquierdo-Casas, Joan, et al. "Low Serum Diamine Oxidase (DAO) Activity Levels in Patients With Migraine." Journal of Physiology and Biochemistry, vol. 74, no. 1, 2018, pp. 93-99.
Izquierdo-Casas J, Comas-Basté O, Latorre-Moratalla ML, et al. Low serum diamine oxidase (DAO) activity levels in patients with migraine. J Physiol Biochem. 2018;74(1):93-99.
Izquierdo-Casas, J., Comas-Basté, O., Latorre-Moratalla, M. L., Lorente-Gascón, M., Duelo, A., Vidal-Carou, M. C., & Soler-Singla, L. (2018). Low serum diamine oxidase (DAO) activity levels in patients with migraine. Journal of Physiology and Biochemistry, 74(1), 93-99. https://doi.org/10.1007/s13105-017-0571-3
Izquierdo-Casas J, et al. Low Serum Diamine Oxidase (DAO) Activity Levels in Patients With Migraine. J Physiol Biochem. 2018;74(1):93-99. PubMed PMID: 28624934.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Low serum diamine oxidase (DAO) activity levels in patients with migraine. AU - Izquierdo-Casas,Joan, AU - Comas-Basté,Oriol, AU - Latorre-Moratalla,M Luz, AU - Lorente-Gascón,Marian, AU - Duelo,Adriana, AU - Vidal-Carou,M Carmen, AU - Soler-Singla,Luis, Y1 - 2017/06/17/ PY - 2017/01/27/received PY - 2017/06/02/accepted PY - 2017/6/19/pubmed PY - 2018/6/13/medline PY - 2017/6/19/entrez KW - Diamine oxidase (DAO) KW - Headache KW - Histamine KW - Histamine intolerance KW - Migraine SP - 93 EP - 99 JF - Journal of physiology and biochemistry JO - J. Physiol. Biochem. VL - 74 IS - 1 N2 - Histamine intolerance is a disorder in the homeostasis of histamine due to a reduced intestinal degradation of this amine, mainly caused by a deficiency in the enzyme diamine oxidase (DAO). Among the several multi-faced symptoms associated with histamine intolerance, headache is one of the most recognized and disabling consequences. The aim of this study was to determine the prevalence of DAO deficiency in patients with a confirmed migraine diagnosis according to the current International Headache Society (IHS) and in non-migraine subjects. DAO activity was assessed in a total of 198 volunteers recruited at the Headache Unit of the Hospital General de Catalunya, 137 in the migraine group and 61 as a control group. DAO enzyme activity in blood samples was determined by ELISA test. Values below 80 HDU/ml (Histamine Degrading Unit/ml) were considered as DAO deficient. Mean value of DAO activity from migraine population (64.5 ± 33.5 HDU/ml) was significantly lower (p < 0.0001) than that obtained from healthy volunteers (91.9 ± 44.3 HDU/ml). DAO deficiency was more prevalent in migraine patients than in the control group. A high incidence rate of DAO deficiency (87%) was observed in the group of patients with migraine. On the other hand, 44% of non-migranous subjects had levels of DAO activity lower than 80 HDU/ml. Despite the multifactorial aetiology of migraine, these results seem to indicate that this enzymatic deficit could be related to the onset of migraine. SN - 1877-8755 UR - https://www.unboundmedicine.com/medline/citation/28624934/Low_serum_diamine_oxidase__DAO__activity_levels_in_patients_with_migraine_ L2 - https://dx.doi.org/10.1007/s13105-017-0571-3 DB - PRIME DP - Unbound Medicine ER -