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Marinesco bodies and substantia nigra neuron density in Parkinson's disease.
Neuropathol Appl Neurobiol. 2017 Dec; 43(7):621-630.NA

Abstract

AIM

Marinesco bodies (MB) are intranuclear inclusions in pigmented neurons of the substantia nigra (SN). While rare in children, frequency increases with normal ageing and is high in Alzheimer's disease, dementia with Lewy bodies and other neurodegenerative disorders. Coinciding with the age-related rise in MB frequency is initiation of cell death among SN neurons. Whether MB have a role in this process is unknown. Our aim is to examine the association of MB with SN neuron density in Parkinson's disease (PD) in the Honolulu-Asia Aging Study.

METHODS

Data on MB and neuron density were measured in SN transverse sections in 131 autopsied men aged 73-99 years at the time of death from 1992 to 2007.

RESULTS

Marinesco body frequency was low in the presence vs. absence of PD (2.3% vs. 6.6%, P < 0.001). After PD onset, MB frequency declined as duration of PD increased (P = 0.006). Similar patterns were observed for SN neuron density. When MB frequency was low, neuron density was noticeably reduced in the SN ventrolateral quadrant, the region most vulnerable to PD neurodegeneration. Low MB frequency was unique to PD as its high frequency in non-PD cases was unrelated to parkinsonian signs and incidental Lewy bodies. Frequency was high in the presence of Alzheimer's disease and apolipoprotein ε4 alleles.

CONCLUSIONS

While findings confirm that MB frequency is low in PD, declines in MB frequency continue with PD duration. The extent to which MB have a distinct relationship with PD warrants clarification. Further studies of MB could be important in understanding PD processes.

Authors+Show Affiliations

Center for Epidemiologic Research in Asia, Shiga University of Medical Science, Otsu, Japan. Pacific Health Research and Education Institute, Honolulu, HI, USA.Pacific Health Research and Education Institute, Honolulu, HI, USA.Pacific Health Research and Education Institute, Honolulu, HI, USA. Department of Medicine, University of Hawaii John A. Burns School of Medicine, Honolulu, HI, USA. Department of Geriatric Medicine and the John A. Hartford Foundation Center of Excellence in Geriatrics, University of Hawaii John A. Burns School of Medicine, Honolulu, HI, USA. Veterans Affairs Pacific Islands Health Care System, Honolulu, HI, USA.Department of Pathology, University of Hawaii John A. Burns School of Medicine, Honolulu, HI, USA.San Francisco Veterans Affairs Medical Center, University of California-San Francisco, San Francisco, CA, USA. Department of Neurology, University of California-San Francisco, San Francisco, CA, USA.Department of Geriatric Medicine and the John A. Hartford Foundation Center of Excellence in Geriatrics, University of Hawaii John A. Burns School of Medicine, Honolulu, HI, USA. Kuakini Medical Center, Honolulu, HI, USA.National Institute on Aging, Bethesda, MD, USA.Pacific Health Research and Education Institute, Honolulu, HI, USA. Veterans Affairs Pacific Islands Health Care System, Honolulu, HI, USA.Pacific Health Research and Education Institute, Honolulu, HI, USA. Department of Geriatric Medicine and the John A. Hartford Foundation Center of Excellence in Geriatrics, University of Hawaii John A. Burns School of Medicine, Honolulu, HI, USA. Veterans Affairs Pacific Islands Health Care System, Honolulu, HI, USA.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

28626918

Citation

Abbott, R D., et al. "Marinesco Bodies and Substantia Nigra Neuron Density in Parkinson's Disease." Neuropathology and Applied Neurobiology, vol. 43, no. 7, 2017, pp. 621-630.
Abbott RD, Nelson JS, Ross GW, et al. Marinesco bodies and substantia nigra neuron density in Parkinson's disease. Neuropathol Appl Neurobiol. 2017;43(7):621-630.
Abbott, R. D., Nelson, J. S., Ross, G. W., Uyehara-Lock, J. H., Tanner, C. M., Masaki, K. H., Launer, L. J., White, L. R., & Petrovitch, H. (2017). Marinesco bodies and substantia nigra neuron density in Parkinson's disease. Neuropathology and Applied Neurobiology, 43(7), 621-630. https://doi.org/10.1111/nan.12419
Abbott RD, et al. Marinesco Bodies and Substantia Nigra Neuron Density in Parkinson's Disease. Neuropathol Appl Neurobiol. 2017;43(7):621-630. PubMed PMID: 28626918.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Marinesco bodies and substantia nigra neuron density in Parkinson's disease. AU - Abbott,R D, AU - Nelson,J S, AU - Ross,G W, AU - Uyehara-Lock,J H, AU - Tanner,C M, AU - Masaki,K H, AU - Launer,L J, AU - White,L R, AU - Petrovitch,H, Y1 - 2017/07/09/ PY - 2017/01/16/received PY - 2017/06/19/accepted PY - 2017/06/12/revised PY - 2017/6/20/pubmed PY - 2018/6/15/medline PY - 2017/6/20/entrez KW - Marinesco bodies KW - Parkinson's disease KW - ageing KW - neurodegeneration KW - substantia nigra SP - 621 EP - 630 JF - Neuropathology and applied neurobiology JO - Neuropathol Appl Neurobiol VL - 43 IS - 7 N2 - AIM: Marinesco bodies (MB) are intranuclear inclusions in pigmented neurons of the substantia nigra (SN). While rare in children, frequency increases with normal ageing and is high in Alzheimer's disease, dementia with Lewy bodies and other neurodegenerative disorders. Coinciding with the age-related rise in MB frequency is initiation of cell death among SN neurons. Whether MB have a role in this process is unknown. Our aim is to examine the association of MB with SN neuron density in Parkinson's disease (PD) in the Honolulu-Asia Aging Study. METHODS: Data on MB and neuron density were measured in SN transverse sections in 131 autopsied men aged 73-99 years at the time of death from 1992 to 2007. RESULTS: Marinesco body frequency was low in the presence vs. absence of PD (2.3% vs. 6.6%, P < 0.001). After PD onset, MB frequency declined as duration of PD increased (P = 0.006). Similar patterns were observed for SN neuron density. When MB frequency was low, neuron density was noticeably reduced in the SN ventrolateral quadrant, the region most vulnerable to PD neurodegeneration. Low MB frequency was unique to PD as its high frequency in non-PD cases was unrelated to parkinsonian signs and incidental Lewy bodies. Frequency was high in the presence of Alzheimer's disease and apolipoprotein ε4 alleles. CONCLUSIONS: While findings confirm that MB frequency is low in PD, declines in MB frequency continue with PD duration. The extent to which MB have a distinct relationship with PD warrants clarification. Further studies of MB could be important in understanding PD processes. SN - 1365-2990 UR - https://www.unboundmedicine.com/medline/citation/28626918/Marinesco_bodies_and_substantia_nigra_neuron_density_in_Parkinson's_disease_ L2 - https://doi.org/10.1111/nan.12419 DB - PRIME DP - Unbound Medicine ER -