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Segmental action of aldosterone on water and electrolyte transport across rabbit colon in vivo.

Abstract

Water and electrolyte transport (Na, K, Cl) and the electrical potential difference were investigated simultaneously in five segments of rabbit colon in vivo, under control conditions and under the influence of aldosterone. A dialysis method was used. The solution was designed to mimic the electrolyte concentration of the lumen, and to simulate normal in vivo conditions. Under in vivo conditions (imposed gradients), marked segmental differences in water and electrolyte transport were present. The proximal colon secreted sodium and absorbed potassium, whereas the distal colon absorbed sodium and secreted potassium. Chloride was secreted in all segments. Aldosterone stimulated water and NaCl absorption in the proximal colon by an electroneutral mechanism, whereas in the distal colon a stimulation of electrogenic Na-absorption occurred. The results demonstrate the role of aldosterone in regulating rabbit colonic electrolyte transport. A uniform hormonal stimulation causes qualitatively and quantitatively different effects in the various segments.

Authors

No affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

2863076

Citation

Clauss, W. "Segmental Action of Aldosterone On Water and Electrolyte Transport Across Rabbit Colon in Vivo." Comparative Biochemistry and Physiology. A, Comparative Physiology, vol. 81, no. 4, 1985, pp. 873-7.
Clauss W. Segmental action of aldosterone on water and electrolyte transport across rabbit colon in vivo. Comp Biochem Physiol A Comp Physiol. 1985;81(4):873-7.
Clauss, W. (1985). Segmental action of aldosterone on water and electrolyte transport across rabbit colon in vivo. Comparative Biochemistry and Physiology. A, Comparative Physiology, 81(4), 873-7.
Clauss W. Segmental Action of Aldosterone On Water and Electrolyte Transport Across Rabbit Colon in Vivo. Comp Biochem Physiol A Comp Physiol. 1985;81(4):873-7. PubMed PMID: 2863076.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Segmental action of aldosterone on water and electrolyte transport across rabbit colon in vivo. A1 - Clauss,W, PY - 1985/1/1/pubmed PY - 1985/1/1/medline PY - 1985/1/1/entrez SP - 873 EP - 7 JF - Comparative biochemistry and physiology. A, Comparative physiology JO - Comp Biochem Physiol A Comp Physiol VL - 81 IS - 4 N2 - Water and electrolyte transport (Na, K, Cl) and the electrical potential difference were investigated simultaneously in five segments of rabbit colon in vivo, under control conditions and under the influence of aldosterone. A dialysis method was used. The solution was designed to mimic the electrolyte concentration of the lumen, and to simulate normal in vivo conditions. Under in vivo conditions (imposed gradients), marked segmental differences in water and electrolyte transport were present. The proximal colon secreted sodium and absorbed potassium, whereas the distal colon absorbed sodium and secreted potassium. Chloride was secreted in all segments. Aldosterone stimulated water and NaCl absorption in the proximal colon by an electroneutral mechanism, whereas in the distal colon a stimulation of electrogenic Na-absorption occurred. The results demonstrate the role of aldosterone in regulating rabbit colonic electrolyte transport. A uniform hormonal stimulation causes qualitatively and quantitatively different effects in the various segments. SN - 0300-9629 UR - https://www.unboundmedicine.com/medline/citation/2863076/Segmental_action_of_aldosterone_on_water_and_electrolyte_transport_across_rabbit_colon_in_vivo_ DB - PRIME DP - Unbound Medicine ER -