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Oxidative stress and psychiatric morbidity in patients with facial acne.
J Cosmet Dermatol. 2018 Apr; 17(2):203-208.JC

Abstract

BACKGROUND

Acne vulgaris is a common cosmetic problem that is frequently associated with psychosocial disturbances as well as increased oxidative stress. However, oxidative stress and psychological aspects have been studied separately in acne.

OBJECTIVE

To evaluate the relationships between oxidative stress, anxiety, depression, and quality of life in acne patients.

METHODS

Sixty patients with facial acne and 40 age- and sex-matched healthy individuals were included in the study. Anxiety and depression were assessed using the Hospital Anxiety and Depression Scale (HADS), and quality of life (QoL) was measured by the Cardiff Acne Disability Index. Disease severity was assessed using the Combined Acne Severity Classification. The serum levels of zinc and malondialdehyde (MDA) and total antioxidant capacity (TAC) were measured in patients and healthy subjects.

RESULTS

The mean HADS scores for anxiety and depression were higher in patients than controls (P<.001 for both). Acne patients showed higher serum MDA and lower TAC and serum zinc levels compared with control subjects (P=.019, P<.001, and P=.028, respectively). Anxiety and depression scores did not correlate with oxidative stress parameters. Patients with moderate/severe acne had worse anxiety scores than mild acne (P=.048), and higher anxiety scores were associated with poorer quality of life (r=.436, P=.001).

CONCLUSION

Our results indicate that the high levels of anxiety and depression in patients with facial acne were not related to oxidative stress. Anxiety was more common than depression and was directly related to QoL impairment.

Authors+Show Affiliations

Faculty of Medicine, Department of Dermatology and Venereology, Assiut University, Assiut, Egypt.Faculty of Medicine, Department of Dermatology and Venereology, Assiut University, Assiut, Egypt.Faculty of Medicine, Department of Medical Biochemistry, Assiut University, Assiut, Egypt.Faculty of Medicine, Department of Medical Biochemistry, Assiut University, Assiut, Egypt.Faculty of Medicine, Department of Medical Biochemistry, Assiut University, Assiut, Egypt.Faculty of Medicine, Department of Neuropsychiatry, Assiut University, Assiut, Egypt.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

28631890

Citation

Awad, Sara M., et al. "Oxidative Stress and Psychiatric Morbidity in Patients With Facial Acne." Journal of Cosmetic Dermatology, vol. 17, no. 2, 2018, pp. 203-208.
Awad SM, Morsy H, Sayed AA, et al. Oxidative stress and psychiatric morbidity in patients with facial acne. J Cosmet Dermatol. 2018;17(2):203-208.
Awad, S. M., Morsy, H., Sayed, A. A., Mohamed, N. A., Ezzat, G. M., & Noaman, M. M. (2018). Oxidative stress and psychiatric morbidity in patients with facial acne. Journal of Cosmetic Dermatology, 17(2), 203-208. https://doi.org/10.1111/jocd.12366
Awad SM, et al. Oxidative Stress and Psychiatric Morbidity in Patients With Facial Acne. J Cosmet Dermatol. 2018;17(2):203-208. PubMed PMID: 28631890.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Oxidative stress and psychiatric morbidity in patients with facial acne. AU - Awad,Sara M, AU - Morsy,Hanan, AU - Sayed,Ayat A, AU - Mohamed,Nahed A, AU - Ezzat,Ghada M, AU - Noaman,Mostafa M, Y1 - 2017/06/20/ PY - 2017/05/22/accepted PY - 2017/6/21/pubmed PY - 2018/10/10/medline PY - 2017/6/21/entrez KW - acne vulgaris KW - anxiety KW - depression KW - oxidative stress SP - 203 EP - 208 JF - Journal of cosmetic dermatology JO - J Cosmet Dermatol VL - 17 IS - 2 N2 - BACKGROUND: Acne vulgaris is a common cosmetic problem that is frequently associated with psychosocial disturbances as well as increased oxidative stress. However, oxidative stress and psychological aspects have been studied separately in acne. OBJECTIVE: To evaluate the relationships between oxidative stress, anxiety, depression, and quality of life in acne patients. METHODS: Sixty patients with facial acne and 40 age- and sex-matched healthy individuals were included in the study. Anxiety and depression were assessed using the Hospital Anxiety and Depression Scale (HADS), and quality of life (QoL) was measured by the Cardiff Acne Disability Index. Disease severity was assessed using the Combined Acne Severity Classification. The serum levels of zinc and malondialdehyde (MDA) and total antioxidant capacity (TAC) were measured in patients and healthy subjects. RESULTS: The mean HADS scores for anxiety and depression were higher in patients than controls (P<.001 for both). Acne patients showed higher serum MDA and lower TAC and serum zinc levels compared with control subjects (P=.019, P<.001, and P=.028, respectively). Anxiety and depression scores did not correlate with oxidative stress parameters. Patients with moderate/severe acne had worse anxiety scores than mild acne (P=.048), and higher anxiety scores were associated with poorer quality of life (r=.436, P=.001). CONCLUSION: Our results indicate that the high levels of anxiety and depression in patients with facial acne were not related to oxidative stress. Anxiety was more common than depression and was directly related to QoL impairment. SN - 1473-2165 UR - https://www.unboundmedicine.com/medline/citation/28631890/Oxidative_stress_and_psychiatric_morbidity_in_patients_with_facial_acne_ L2 - https://doi.org/10.1111/jocd.12366 DB - PRIME DP - Unbound Medicine ER -