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What really is an indeterminate FNA thyroid nodule?
Ann Ital Chir. 2017; 88:275-281.AI

Abstract

BACKGROUND

Thyroid nodules are usually benign; however, 5 to 15% prove to be malignant. Fine-needle aspiration (FNA) has become the gold standard in the evaluation of thyroid nodules, especially in single nodule more than a centimeter and / or in smaller nodule with ultrasound characters of malignancy.

METHODS

We evaluated retrospectively 179 patients with "undetermined" thyroid fine needle aspiration, undergoing surgery. We compared cytology and histology and we evaluated sex, age, the presence of thyroiditis and dimension of the indeterminate nodule as predictors of malignancy.

RESULTS

In 48 patients (26.8%) histological examination confirmed the indeterminate cytological diagnosis and this means that the nodule underwent FNA was diagnosed in effects such as cancer. In 29 patients, on histological examination, the nodule underwent FNA was not diagnosed as cancer, but one or more carcinomas were diagnosed in the same lobe of indeterminate nodule, but in different location and / or in the contralateral lobe. In 102 patients, the definitive histological examination did not confirm the suspected diagnosis and we found a significant positive association only between male sex and histological malignancy.

CONCLUSIONS

The indeterminate FNA still remains a challenge for the surgeon because it is not yet possible to discriminate patients who really need surgery from those that can be followed in follow-up. The potential of molecular diagnostics for thyroid nodules with indeterminate cytology is promising, but many of these markers are too complex or expensive for routine clinical use or are still poorly standardized.

KEY WORDS

Indeterminate FNA, Thyroid, Thyroid fine needle aspiration.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

28632145

Citation

Pezzolla, Angela, et al. "What Really Is an Indeterminate FNA Thyroid Nodule?" Annali Italiani Di Chirurgia, vol. 88, 2017, pp. 275-281.
Pezzolla A, Lattarulo S, Madaro A, et al. What really is an indeterminate FNA thyroid nodule? Ann Ital Chir. 2017;88:275-281.
Pezzolla, A., Lattarulo, S., Madaro, A., Docimo, G., Lacalendola, E., Prete, F., & Marzaioli, R. (2017). What really is an indeterminate FNA thyroid nodule? Annali Italiani Di Chirurgia, 88, 275-281.
Pezzolla A, et al. What Really Is an Indeterminate FNA Thyroid Nodule. Ann Ital Chir. 2017;88:275-281. PubMed PMID: 28632145.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - What really is an indeterminate FNA thyroid nodule? AU - Pezzolla,Angela, AU - Lattarulo,Serafina, AU - Madaro,Andrea, AU - Docimo,Giovanni, AU - Lacalendola,Emanuela, AU - Prete,Francesco, AU - Marzaioli,Rinaldo, PY - 2017/6/21/pubmed PY - 2018/7/13/medline PY - 2017/6/21/entrez SP - 275 EP - 281 JF - Annali italiani di chirurgia JO - Ann Ital Chir VL - 88 N2 - BACKGROUND: Thyroid nodules are usually benign; however, 5 to 15% prove to be malignant. Fine-needle aspiration (FNA) has become the gold standard in the evaluation of thyroid nodules, especially in single nodule more than a centimeter and / or in smaller nodule with ultrasound characters of malignancy. METHODS: We evaluated retrospectively 179 patients with "undetermined" thyroid fine needle aspiration, undergoing surgery. We compared cytology and histology and we evaluated sex, age, the presence of thyroiditis and dimension of the indeterminate nodule as predictors of malignancy. RESULTS: In 48 patients (26.8%) histological examination confirmed the indeterminate cytological diagnosis and this means that the nodule underwent FNA was diagnosed in effects such as cancer. In 29 patients, on histological examination, the nodule underwent FNA was not diagnosed as cancer, but one or more carcinomas were diagnosed in the same lobe of indeterminate nodule, but in different location and / or in the contralateral lobe. In 102 patients, the definitive histological examination did not confirm the suspected diagnosis and we found a significant positive association only between male sex and histological malignancy. CONCLUSIONS: The indeterminate FNA still remains a challenge for the surgeon because it is not yet possible to discriminate patients who really need surgery from those that can be followed in follow-up. The potential of molecular diagnostics for thyroid nodules with indeterminate cytology is promising, but many of these markers are too complex or expensive for routine clinical use or are still poorly standardized. KEY WORDS: Indeterminate FNA, Thyroid, Thyroid fine needle aspiration. SN - 2239-253X UR - https://www.unboundmedicine.com/medline/citation/28632145/What_really_is_an_indeterminate_FNA_thyroid_nodule L2 - https://medlineplus.gov/thyroidcancer.html DB - PRIME DP - Unbound Medicine ER -