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The effect of flaxseed supplementation on body weight and body composition: a systematic review and meta-analysis of 45 randomized placebo-controlled trials.
Obes Rev. 2017 09; 18(9):1096-1107.OR

Abstract

Flaxseed consumption may be inversely associated with obesity; however, findings of available randomized controlled trials (RCTs) are conflicting. The present study aimed to systematically review and analyse RCTs assessing the effects of flaxseed consumption on body weight and body composition. PubMed, Medline via Ovid, SCOPUS, EMBASE and ISI Web of Sciences databases were searched up to November 2016. Mean changes in body composition indices including body weight, body mass index (BMI) and waist circumference were extracted. Effect sizes were expressed as weighted mean difference (WMD) and 95% confidence intervals (CI). Heterogeneity between studies was assessed with the I2 test. Publication bias and subgroup analyses were also performed. The quality of articles was assessed via the Jadad scale. A total of 45 RCTs were included. Meta-analyses suggested a significant reduction in body weight (WMD: -0.99 kg, 95% CI: -1.67, -0.31, p = 0.004), BMI (WMD: -0.30 kg m-2 , 95% CI: -0.53, -0.08, p = 0.008) and waist circumference (WMD: -0.80 cm, 95% CI: -1.40, -0.20, p = 0.008) following flaxseed supplementation. Subgroup analyses showed that using whole flaxseed in doses ≥30 g d-1 , longer-term interventions (≥12 weeks) and studies including participants with higher BMI (≥ 27 kg m-2) had positive effects on body composition. Whole flaxseed is a good choice for weight management particularly for weight reduction in overweight and obese participants.

Authors+Show Affiliations

Department of Clinical Nutrition, School of Nutrition and Food Sciences, Shiraz University of Medical Sciences, Shiraz, Iran. Meta-Research Innovation Office, School of Nutrition and Food Sciences, Shiraz University of Medical Sciences, Shiraz, Iran.Department of Clinical Nutrition, School of Nutrition and Food Sciences, Shiraz University of Medical Sciences, Shiraz, Iran. Meta-Research Innovation Office, School of Nutrition and Food Sciences, Shiraz University of Medical Sciences, Shiraz, Iran.Department of Clinical Nutrition, School of Nutrition and Food Sciences, Shiraz University of Medical Sciences, Shiraz, Iran. Meta-Research Innovation Office, School of Nutrition and Food Sciences, Shiraz University of Medical Sciences, Shiraz, Iran.Meta-Research Innovation Office, School of Nutrition and Food Sciences, Shiraz University of Medical Sciences, Shiraz, Iran. Department of Community Nutrition, School of Nutrition and Food Sciences, Shiraz University of Medical Sciences, Shiraz, Iran.School of Nutrition, Ryerson University, Toronto, Ontario, Canada.School of Nutrition, Ryerson University, Toronto, Ontario, Canada.

Pub Type(s)

Journal Article
Meta-Analysis
Review
Systematic Review

Language

eng

PubMed ID

28635182

Citation

Mohammadi-Sartang, M, et al. "The Effect of Flaxseed Supplementation On Body Weight and Body Composition: a Systematic Review and Meta-analysis of 45 Randomized Placebo-controlled Trials." Obesity Reviews : an Official Journal of the International Association for the Study of Obesity, vol. 18, no. 9, 2017, pp. 1096-1107.
Mohammadi-Sartang M, Mazloom Z, Raeisi-Dehkordi H, et al. The effect of flaxseed supplementation on body weight and body composition: a systematic review and meta-analysis of 45 randomized placebo-controlled trials. Obes Rev. 2017;18(9):1096-1107.
Mohammadi-Sartang, M., Mazloom, Z., Raeisi-Dehkordi, H., Barati-Boldaji, R., Bellissimo, N., & Totosy de Zepetnek, J. O. (2017). The effect of flaxseed supplementation on body weight and body composition: a systematic review and meta-analysis of 45 randomized placebo-controlled trials. Obesity Reviews : an Official Journal of the International Association for the Study of Obesity, 18(9), 1096-1107. https://doi.org/10.1111/obr.12550
Mohammadi-Sartang M, et al. The Effect of Flaxseed Supplementation On Body Weight and Body Composition: a Systematic Review and Meta-analysis of 45 Randomized Placebo-controlled Trials. Obes Rev. 2017;18(9):1096-1107. PubMed PMID: 28635182.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The effect of flaxseed supplementation on body weight and body composition: a systematic review and meta-analysis of 45 randomized placebo-controlled trials. AU - Mohammadi-Sartang,M, AU - Mazloom,Z, AU - Raeisi-Dehkordi,H, AU - Barati-Boldaji,R, AU - Bellissimo,N, AU - Totosy de Zepetnek,J O, Y1 - 2017/06/21/ PY - 2017/01/03/received PY - 2017/03/02/revised PY - 2017/03/09/accepted PY - 2017/6/22/pubmed PY - 2018/5/4/medline PY - 2017/6/22/entrez KW - Body mass index KW - body weight KW - flax KW - obesity SP - 1096 EP - 1107 JF - Obesity reviews : an official journal of the International Association for the Study of Obesity JO - Obes Rev VL - 18 IS - 9 N2 - Flaxseed consumption may be inversely associated with obesity; however, findings of available randomized controlled trials (RCTs) are conflicting. The present study aimed to systematically review and analyse RCTs assessing the effects of flaxseed consumption on body weight and body composition. PubMed, Medline via Ovid, SCOPUS, EMBASE and ISI Web of Sciences databases were searched up to November 2016. Mean changes in body composition indices including body weight, body mass index (BMI) and waist circumference were extracted. Effect sizes were expressed as weighted mean difference (WMD) and 95% confidence intervals (CI). Heterogeneity between studies was assessed with the I2 test. Publication bias and subgroup analyses were also performed. The quality of articles was assessed via the Jadad scale. A total of 45 RCTs were included. Meta-analyses suggested a significant reduction in body weight (WMD: -0.99 kg, 95% CI: -1.67, -0.31, p = 0.004), BMI (WMD: -0.30 kg m-2 , 95% CI: -0.53, -0.08, p = 0.008) and waist circumference (WMD: -0.80 cm, 95% CI: -1.40, -0.20, p = 0.008) following flaxseed supplementation. Subgroup analyses showed that using whole flaxseed in doses ≥30 g d-1 , longer-term interventions (≥12 weeks) and studies including participants with higher BMI (≥ 27 kg m-2) had positive effects on body composition. Whole flaxseed is a good choice for weight management particularly for weight reduction in overweight and obese participants. SN - 1467-789X UR - https://www.unboundmedicine.com/medline/citation/28635182/The_effect_of_flaxseed_supplementation_on_body_weight_and_body_composition:_a_systematic_review_and_meta_analysis_of_45_randomized_placebo_controlled_trials_ L2 - https://doi.org/10.1111/obr.12550 DB - PRIME DP - Unbound Medicine ER -