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A Stretchable Electrochemical Sensor for Inducing and Monitoring Cell Mechanotransduction in Real Time.
Angew Chem Int Ed Engl. 2017 08 01; 56(32):9454-9458.AC

Abstract

Existing methods offer little direct and real-time information about stretch-triggered biochemical responses during cell mechanotransduction. A novel stretchable electrochemical sensor is reported that takes advantage of a hierarchical percolation network of carbon nanotubes and gold nanotubes (CNT-AuNT). This hybrid nanostructure provides the sensor with excellent time-reproducible mechanical and electrochemical performances while granting very good cellular compatibility, making it perfectly apt to induce and monitor simultaneously transient biochemical signals. This is validated by monitoring stretch-induced transient release of small signaling molecules by both endothelial and epithelial cells cultured on this sensor and submitted to stretching strains of different intensities. This work demonstrates that the hybrid CNT-AuNT platform offers a versatile and highly sensitive way to characterize and quantify short-time mechanotransduction responses.

Authors+Show Affiliations

Key Laboratory of Analytical Chemistry for Biology and Medicine (Ministry of Education), College of Chemistry and Molecular Sciences, Wuhan University, Wuhan, 430072, China.Key Laboratory of Analytical Chemistry for Biology and Medicine (Ministry of Education), College of Chemistry and Molecular Sciences, Wuhan University, Wuhan, 430072, China.Key Laboratory of Analytical Chemistry for Biology and Medicine (Ministry of Education), College of Chemistry and Molecular Sciences, Wuhan University, Wuhan, 430072, China.Key Laboratory of Analytical Chemistry for Biology and Medicine (Ministry of Education), College of Chemistry and Molecular Sciences, Wuhan University, Wuhan, 430072, China.Key Laboratory of Analytical Chemistry for Biology and Medicine (Ministry of Education), College of Chemistry and Molecular Sciences, Wuhan University, Wuhan, 430072, China.Key Laboratory of Analytical Chemistry for Biology and Medicine (Ministry of Education), College of Chemistry and Molecular Sciences, Wuhan University, Wuhan, 430072, China.PASTEUR, Département de chimie, École normale supérieure, PSL Research University, Sorbonne Universités, UPMC Univ. Paris 06, CNRS, 24 rue Lhomond, 75005, Paris, France. State Key Laboratory of Physical Chemistry of Solid Surfaces, College of Chemistry and Chemical Engineering, Xiamen University, China.Key Laboratory of Analytical Chemistry for Biology and Medicine (Ministry of Education), College of Chemistry and Molecular Sciences, Wuhan University, Wuhan, 430072, China.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

28636246

Citation

Liu, Yan-Ling, et al. "A Stretchable Electrochemical Sensor for Inducing and Monitoring Cell Mechanotransduction in Real Time." Angewandte Chemie (International Ed. in English), vol. 56, no. 32, 2017, pp. 9454-9458.
Liu YL, Qin Y, Jin ZH, et al. A Stretchable Electrochemical Sensor for Inducing and Monitoring Cell Mechanotransduction in Real Time. Angew Chem Int Ed Engl. 2017;56(32):9454-9458.
Liu, Y. L., Qin, Y., Jin, Z. H., Hu, X. B., Chen, M. M., Liu, R., Amatore, C., & Huang, W. H. (2017). A Stretchable Electrochemical Sensor for Inducing and Monitoring Cell Mechanotransduction in Real Time. Angewandte Chemie (International Ed. in English), 56(32), 9454-9458. https://doi.org/10.1002/anie.201705215
Liu YL, et al. A Stretchable Electrochemical Sensor for Inducing and Monitoring Cell Mechanotransduction in Real Time. Angew Chem Int Ed Engl. 2017 08 1;56(32):9454-9458. PubMed PMID: 28636246.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A Stretchable Electrochemical Sensor for Inducing and Monitoring Cell Mechanotransduction in Real Time. AU - Liu,Yan-Ling, AU - Qin,Yu, AU - Jin,Zi-He, AU - Hu,Xue-Bo, AU - Chen,Miao-Miao, AU - Liu,Rong, AU - Amatore,Christian, AU - Huang,Wei-Hua, Y1 - 2017/07/06/ PY - 2017/05/20/received PY - 2017/6/22/pubmed PY - 2019/3/7/medline PY - 2017/6/22/entrez KW - biosensors KW - cell mechanotransduction KW - electrochemical detection KW - hierarchical networks KW - stretchable sensors SP - 9454 EP - 9458 JF - Angewandte Chemie (International ed. in English) JO - Angew. Chem. Int. Ed. Engl. VL - 56 IS - 32 N2 - Existing methods offer little direct and real-time information about stretch-triggered biochemical responses during cell mechanotransduction. A novel stretchable electrochemical sensor is reported that takes advantage of a hierarchical percolation network of carbon nanotubes and gold nanotubes (CNT-AuNT). This hybrid nanostructure provides the sensor with excellent time-reproducible mechanical and electrochemical performances while granting very good cellular compatibility, making it perfectly apt to induce and monitor simultaneously transient biochemical signals. This is validated by monitoring stretch-induced transient release of small signaling molecules by both endothelial and epithelial cells cultured on this sensor and submitted to stretching strains of different intensities. This work demonstrates that the hybrid CNT-AuNT platform offers a versatile and highly sensitive way to characterize and quantify short-time mechanotransduction responses. SN - 1521-3773 UR - https://www.unboundmedicine.com/medline/citation/28636246/A_Stretchable_Electrochemical_Sensor_for_Inducing_and_Monitoring_Cell_Mechanotransduction_in_Real_Time_ L2 - https://doi.org/10.1002/anie.201705215 DB - PRIME DP - Unbound Medicine ER -