Tags

Type your tag names separated by a space and hit enter

Immunopathology of Chikungunya Virus Infection: Lessons Learned from Patients and Animal Models.
Annu Rev Virol. 2017 09 29; 4(1):413-427.AR

Abstract

Chikungunya virus (CHIKV) is an arthropod-borne alphavirus that causes acute and chronic arthritis. The virus reemerged in the Indian Ocean islands in 2005-2006 and is responsible for outbreaks in the Caribbean islands and the Americas since late 2013. Despite the wealth of research over the past 10 years, there are no commercially available antiviral drugs or vaccines. Treatment usually involves analgesics, anti-inflammatory drugs, and supportive care. Most studies have been focused on understanding the pathogenesis of CHIKV infection through clinical observation and with animal models. In this review, the clinical manifestations of CHIKV that define the disease and the use of relevant animal models, from mice to nonhuman primates, are discussed. Understanding key cellular factors in CHIKV infection and the interplay with the immune system will aid in the development of preventive and therapeutic approaches to combat this painful viral disease in humans.

Authors+Show Affiliations

Singapore Immunology Network (SIgN), Agency for Science, Technology and Research (A*STAR), Singapore 138648; email: lisa_ng@immunol.a-star.edu.sg. Institute of Infection and Global Health, University of Liverpool, Liverpool L69 3BX, United Kingdom.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

28637387

Citation

Ng, Lisa F P.. "Immunopathology of Chikungunya Virus Infection: Lessons Learned From Patients and Animal Models." Annual Review of Virology, vol. 4, no. 1, 2017, pp. 413-427.
Ng LFP. Immunopathology of Chikungunya Virus Infection: Lessons Learned from Patients and Animal Models. Annu Rev Virol. 2017;4(1):413-427.
Ng, L. F. P. (2017). Immunopathology of Chikungunya Virus Infection: Lessons Learned from Patients and Animal Models. Annual Review of Virology, 4(1), 413-427. https://doi.org/10.1146/annurev-virology-101416-041808
Ng LFP. Immunopathology of Chikungunya Virus Infection: Lessons Learned From Patients and Animal Models. Annu Rev Virol. 2017 09 29;4(1):413-427. PubMed PMID: 28637387.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Immunopathology of Chikungunya Virus Infection: Lessons Learned from Patients and Animal Models. A1 - Ng,Lisa F P, Y1 - 2017/06/21/ PY - 2017/6/24/pubmed PY - 2017/10/28/medline PY - 2017/6/23/entrez KW - adaptive immunity KW - immune mediators KW - immune regulation KW - infection KW - innate immunity KW - protection SP - 413 EP - 427 JF - Annual review of virology JO - Annu Rev Virol VL - 4 IS - 1 N2 - Chikungunya virus (CHIKV) is an arthropod-borne alphavirus that causes acute and chronic arthritis. The virus reemerged in the Indian Ocean islands in 2005-2006 and is responsible for outbreaks in the Caribbean islands and the Americas since late 2013. Despite the wealth of research over the past 10 years, there are no commercially available antiviral drugs or vaccines. Treatment usually involves analgesics, anti-inflammatory drugs, and supportive care. Most studies have been focused on understanding the pathogenesis of CHIKV infection through clinical observation and with animal models. In this review, the clinical manifestations of CHIKV that define the disease and the use of relevant animal models, from mice to nonhuman primates, are discussed. Understanding key cellular factors in CHIKV infection and the interplay with the immune system will aid in the development of preventive and therapeutic approaches to combat this painful viral disease in humans. SN - 2327-0578 UR - https://www.unboundmedicine.com/medline/citation/28637387/Immunopathology_of_Chikungunya_Virus_Infection:_Lessons_Learned_from_Patients_and_Animal_Models_ L2 - https://arjournals.annualreviews.org/doi/10.1146/annurev-virology-101416-041808?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -