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Pancreatic somatostatin.
Adv Exp Med Biol. 1985; 188:403-23.AE

Abstract

This is a review of pancreatic somatostatin which is limited in its scope and therefore focuses upon some selected issues. Throughout the entire review the same basic questions recur: Why do islets contain somatostatin? What is the physiological role of somatostatin and what does this peptide have to do with diabetes? Clear answers to these questions do not emerge, but a number of hunches are explored. The review provides a very brief look at somatostatin secretion, a discussion of the potential interactions which islet D cells might have with other islet cell types, consideration of how knowledge of islet anatomy may help us understand the D cell, and finally some comments about what happens to the D cell in diabetes and fasting.

Authors

Weir GC
No affiliation info available
Bonner-Weir S
No affiliation info available

MeSH

AnimalsDiabetes MellitusGlucagonGlucoseHumansInsulinInsulin SecretionIslets of LangerhansObesitySomatostatin

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.
Review

Language

eng

PubMed ID

2863944

Citation

Weir, G C., and S Bonner-Weir. "Pancreatic Somatostatin." Advances in Experimental Medicine and Biology, vol. 188, 1985, pp. 403-23.
Weir GC, Bonner-Weir S. Pancreatic somatostatin. Adv Exp Med Biol. 1985;188:403-23.
Weir, G. C., & Bonner-Weir, S. (1985). Pancreatic somatostatin. Advances in Experimental Medicine and Biology, 188, 403-23.
Weir GC, Bonner-Weir S. Pancreatic Somatostatin. Adv Exp Med Biol. 1985;188:403-23. PubMed PMID: 2863944.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Pancreatic somatostatin. AU - Weir,G C, AU - Bonner-Weir,S, PY - 1985/1/1/pubmed PY - 1985/1/1/medline PY - 1985/1/1/entrez SP - 403 EP - 23 JF - Advances in experimental medicine and biology JO - Adv Exp Med Biol VL - 188 N2 - This is a review of pancreatic somatostatin which is limited in its scope and therefore focuses upon some selected issues. Throughout the entire review the same basic questions recur: Why do islets contain somatostatin? What is the physiological role of somatostatin and what does this peptide have to do with diabetes? Clear answers to these questions do not emerge, but a number of hunches are explored. The review provides a very brief look at somatostatin secretion, a discussion of the potential interactions which islet D cells might have with other islet cell types, consideration of how knowledge of islet anatomy may help us understand the D cell, and finally some comments about what happens to the D cell in diabetes and fasting. SN - 0065-2598 UR - https://www.unboundmedicine.com/medline/citation/2863944/Pancreatic_somatostatin_ DB - PRIME DP - Unbound Medicine ER -