Tags

Type your tag names separated by a space and hit enter

Atherosclerosis and the Hydrogen Sulfide Signaling Pathway - Therapeutic Approaches to Disease Prevention.
Cell Physiol Biochem. 2017; 42(3):859-875.CP

Abstract

Hydrogen sulfide (H2S) is now admitted as a third gasotransmitter together with nitric oxide (NO) and carbon monoxide (CO), albeit it was originally considered as a foul and poisonous gas. Endogenous H2S production in mammalian cells is counting on the three enzymes acting on cysteine. Involvement of H2S in various physiological and pathological processes has been extensively studied in the last fifteen years. Mounting evidence suggests that H2S is able to protect against atherosclerosis development and progression. Exogenous H2S supplement has salutary effects on atherogenesis, and reduction of the endogenous H2S level accelerates atherosclerosis. The anti-atherosclerotic mechanisms of H2S have been descried in different aspects, including endothelium preservation, antioxidative action, anti-inflammatory responses, vasorelaxation, regulation of ion channels, etc. However, further investigation is still needed to help us gain more insights into the fundamental underlying mechanisms, and that will allow us to design better therapeutic applications of H2S in the treatment of atherosclerosis.

Authors+Show Affiliations

School of Pharmacy and State Key Laboratory of Quality Research in Chinese Medicine, Macau University of Science & Technology, Macau, China. Shanghai Key Laboratory of Bioactive Small Molecules, Department of Pharmacology, School of Pharmacy, Fudan University, Shanghai, China.Department of Pharmacy, Huashan Hospital, Fudan University, Shanghai, China. Shanghai Key Laboratory of Bioactive Small Molecules, Department of Pharmacology, School of Pharmacy, Fudan University, Shanghai, China.Shanghai Key Laboratory of Bioactive Small Molecules, Department of Pharmacology, School of Pharmacy, Fudan University, Shanghai, China.School of Pharmacy and State Key Laboratory of Quality Research in Chinese Medicine, Macau University of Science & Technology, Macau, China. Shanghai Key Laboratory of Bioactive Small Molecules, Department of Pharmacology, School of Pharmacy, Fudan University, Shanghai, China.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

28641276

Citation

Wang, Zhi-Jun, et al. "Atherosclerosis and the Hydrogen Sulfide Signaling Pathway - Therapeutic Approaches to Disease Prevention." Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology, vol. 42, no. 3, 2017, pp. 859-875.
Wang ZJ, Wu J, Guo W, et al. Atherosclerosis and the Hydrogen Sulfide Signaling Pathway - Therapeutic Approaches to Disease Prevention. Cell Physiol Biochem. 2017;42(3):859-875.
Wang, Z. J., Wu, J., Guo, W., & Zhu, Y. Z. (2017). Atherosclerosis and the Hydrogen Sulfide Signaling Pathway - Therapeutic Approaches to Disease Prevention. Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology, 42(3), 859-875. https://doi.org/10.1159/000478628
Wang ZJ, et al. Atherosclerosis and the Hydrogen Sulfide Signaling Pathway - Therapeutic Approaches to Disease Prevention. Cell Physiol Biochem. 2017;42(3):859-875. PubMed PMID: 28641276.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Atherosclerosis and the Hydrogen Sulfide Signaling Pathway - Therapeutic Approaches to Disease Prevention. AU - Wang,Zhi-Jun, AU - Wu,Jian, AU - Guo,Wei, AU - Zhu,Yi-Zhun, Y1 - 2017/06/23/ PY - 2017/03/21/received PY - 2017/04/11/accepted PY - 2017/6/24/pubmed PY - 2017/11/8/medline PY - 2017/6/23/entrez KW - ApoE KW - Atherosclerosis KW - CSE KW - Gasotransmitter KW - H2S SP - 859 EP - 875 JF - Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology JO - Cell Physiol Biochem VL - 42 IS - 3 N2 - Hydrogen sulfide (H2S) is now admitted as a third gasotransmitter together with nitric oxide (NO) and carbon monoxide (CO), albeit it was originally considered as a foul and poisonous gas. Endogenous H2S production in mammalian cells is counting on the three enzymes acting on cysteine. Involvement of H2S in various physiological and pathological processes has been extensively studied in the last fifteen years. Mounting evidence suggests that H2S is able to protect against atherosclerosis development and progression. Exogenous H2S supplement has salutary effects on atherogenesis, and reduction of the endogenous H2S level accelerates atherosclerosis. The anti-atherosclerotic mechanisms of H2S have been descried in different aspects, including endothelium preservation, antioxidative action, anti-inflammatory responses, vasorelaxation, regulation of ion channels, etc. However, further investigation is still needed to help us gain more insights into the fundamental underlying mechanisms, and that will allow us to design better therapeutic applications of H2S in the treatment of atherosclerosis. SN - 1421-9778 UR - https://www.unboundmedicine.com/medline/citation/28641276/Atherosclerosis_and_the_Hydrogen_Sulfide_Signaling_Pathway___Therapeutic_Approaches_to_Disease_Prevention_ L2 - https://www.karger.com?DOI=10.1159/000478628 DB - PRIME DP - Unbound Medicine ER -