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Relevance of Cat and Dog Sensitization by Skin Prick Testing in Childhood Eczema and Asthma.
Curr Pediatr Rev. 2017; 13(2):120-125.CP

Abstract

BACKGROUND

Household animal dander has been implicated as aeroallergen in childhood atopic diseases. Many parents seek healthcare advice if household pet keeping may be detrimental in atopic eczema (AE), allergic rhinitis and asthma.

AIM

We investigated if skin sensitization by cat/dog dander was associated with disease severity and quality of life in children with AE.

METHODS

Demographics, skin prick test (SPT) results, disease severity (Nottingham eczema severity score NESS), Children Dermatology Life Quality Index (CDLQI), blood IgE and eosinophil counts of a cohort of AE patients were reviewed.

RESULTS

325 AE patients followed at a pediatric dermatology clinic were evaluated. Personal history of asthma was lowest (20%) in the dog-dander-positive-group but highest (61%) in bothcat- and-dog-dander-positive group (p=0.007). Binomial logistic regression ascertained that catdander sensitization was associated with increasing age (adjusted odds ratio [aOR], 1.056; 95% Confidence Interval [CI], 1.006 to 1.109; p=0.029), dust-mite sensitization (aOR, 4.625; 95% CI, 1.444 to 14.815; p=0.010), food-allergen sensitization (aOR, 2.330; 95% CI, 1.259 to 4.310; p=0.007) and keeping-cat-ever (aOR, 7.325; 95% CI, 1.193 to 44.971; p=0.032); whereas dogdander sensitization was associated with dust-mite sensitization (aOR, 9.091; 95% CI, 1.148 to 71.980; p=0.037), food-allergen sensitization (aOR, 3.568; 95% CI, 1.341 to 9.492; p=0.011) and keeping-dog-ever (aOR, 6.809; 95% CI, 2.179 to 21.281; p=0.001). However, neither cat nor dog sensitization were associated with asthma, allergic rhinitis, parental or sibling atopic status, disease severity or quality of life.

CONCLUSION

Physicians should advise parents that there is no direct correlation between AE severity, quality of life, asthma or allergic rhinitis with cutaneous sensitization to cats or dogs. Sensitized patients especially those with concomitant asthma and severe symptoms may consider non-furry alternatives if they plan to have a pet. Highly sensitized individuals, especially those with asthma co-morbidity, may have to remove their pet for a trial period to determine if symptoms improve.

Authors+Show Affiliations

The Chinese University of Hong Kong, 6/F, Clinical Sciences Building, Prince of Wales Hospital, Shatin, Hong Kong SAR. China.The Chinese University of Hong Kong, 6/F, Clinical Sciences Building, Prince of Wales Hospital, Shatin, Hong Kong SAR. China.The Chinese University of Hong Kong, 6/F, Clinical Sciences Building, Prince of Wales Hospital, Shatin, Hong Kong SAR. China.The Chinese University of Hong Kong, 6/F, Clinical Sciences Building, Prince of Wales Hospital, Shatin, Hong Kong SAR. China.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

28641549

Citation

Hon, Kam Lun, et al. "Relevance of Cat and Dog Sensitization By Skin Prick Testing in Childhood Eczema and Asthma." Current Pediatric Reviews, vol. 13, no. 2, 2017, pp. 120-125.
Hon KL, Tsang KYC, Pong NHH, et al. Relevance of Cat and Dog Sensitization by Skin Prick Testing in Childhood Eczema and Asthma. Curr Pediatr Rev. 2017;13(2):120-125.
Hon, K. L., Tsang, K. Y. C., Pong, N. H. H., & Leung, T. F. (2017). Relevance of Cat and Dog Sensitization by Skin Prick Testing in Childhood Eczema and Asthma. Current Pediatric Reviews, 13(2), 120-125. https://doi.org/10.2174/1573396313666170615085018
Hon KL, et al. Relevance of Cat and Dog Sensitization By Skin Prick Testing in Childhood Eczema and Asthma. Curr Pediatr Rev. 2017;13(2):120-125. PubMed PMID: 28641549.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Relevance of Cat and Dog Sensitization by Skin Prick Testing in Childhood Eczema and Asthma. AU - Hon,Kam Lun, AU - Tsang,Kathy Yin Ching, AU - Pong,Nga Hin Henry, AU - Leung,Ting Fan, PY - 2017/02/07/received PY - 2017/05/08/revised PY - 2017/05/12/accepted PY - 2017/6/24/pubmed PY - 2018/2/22/medline PY - 2017/6/24/entrez KW - Atopic dermatitis KW - CDLQI KW - NESS KW - atopic eczema KW - cat KW - children KW - dog KW - food avoidance KW - pet KW - quality of life SP - 120 EP - 125 JF - Current pediatric reviews JO - Curr Pediatr Rev VL - 13 IS - 2 N2 - BACKGROUND: Household animal dander has been implicated as aeroallergen in childhood atopic diseases. Many parents seek healthcare advice if household pet keeping may be detrimental in atopic eczema (AE), allergic rhinitis and asthma. AIM: We investigated if skin sensitization by cat/dog dander was associated with disease severity and quality of life in children with AE. METHODS: Demographics, skin prick test (SPT) results, disease severity (Nottingham eczema severity score NESS), Children Dermatology Life Quality Index (CDLQI), blood IgE and eosinophil counts of a cohort of AE patients were reviewed. RESULTS: 325 AE patients followed at a pediatric dermatology clinic were evaluated. Personal history of asthma was lowest (20%) in the dog-dander-positive-group but highest (61%) in bothcat- and-dog-dander-positive group (p=0.007). Binomial logistic regression ascertained that catdander sensitization was associated with increasing age (adjusted odds ratio [aOR], 1.056; 95% Confidence Interval [CI], 1.006 to 1.109; p=0.029), dust-mite sensitization (aOR, 4.625; 95% CI, 1.444 to 14.815; p=0.010), food-allergen sensitization (aOR, 2.330; 95% CI, 1.259 to 4.310; p=0.007) and keeping-cat-ever (aOR, 7.325; 95% CI, 1.193 to 44.971; p=0.032); whereas dogdander sensitization was associated with dust-mite sensitization (aOR, 9.091; 95% CI, 1.148 to 71.980; p=0.037), food-allergen sensitization (aOR, 3.568; 95% CI, 1.341 to 9.492; p=0.011) and keeping-dog-ever (aOR, 6.809; 95% CI, 2.179 to 21.281; p=0.001). However, neither cat nor dog sensitization were associated with asthma, allergic rhinitis, parental or sibling atopic status, disease severity or quality of life. CONCLUSION: Physicians should advise parents that there is no direct correlation between AE severity, quality of life, asthma or allergic rhinitis with cutaneous sensitization to cats or dogs. Sensitized patients especially those with concomitant asthma and severe symptoms may consider non-furry alternatives if they plan to have a pet. Highly sensitized individuals, especially those with asthma co-morbidity, may have to remove their pet for a trial period to determine if symptoms improve. SN - 1875-6336 UR - https://www.unboundmedicine.com/medline/citation/28641549/Relevance_of_Cat_and_Dog_Sensitization_by_Skin_Prick_Testing_in_Childhood_Eczema_and_Asthma_ L2 - http://www.eurekaselect.com/153213/article DB - PRIME DP - Unbound Medicine ER -