Tags

Type your tag names separated by a space and hit enter

Neuroanatomical correlates of familial risk-for-depression and religiosity/spirituality.

Abstract

OBJECTIVE

To examine potential neural substrates that underlie the interplay between religiosity/spirituality and risk-for-depression. A new wave of data from a longitudinal, three generation study of individuals at high risk for depression is presented. In addition to providing new longitudinal data, we extend previous findings by employing additional (surface-based) methods for examining cortical volume.

MEASURES PARTICIPANTS AND METHODS

Magnetic resonance imaging (MRI) scans were collected on 106 second and third generation family members at high or low risk for major depression defined by the presence or absence of depression in the first generation. Religiosity/spirituality measures were collected at the same time as the MRI scans and comprised self-report ratings of personal religious/spiritual (R/S) importance and frequency of religious attendance. Analyses were carried out with Freesurfer. Interactive effects of religiosity/spirituality and risk-for-depression were examined on measures of cortical thickness and cortical surface area.

RESULTS

A high degree of belief in the importance of religion/spirituality was associated with both a thicker cortex and a larger pial surface area in persons at high risk for familial depression. No significant association was found between cortical regions and religious attendance in either risk group.

CONCLUSIONS AND RELEVANCE

The results support previous findings of an association between R/S importance and cortical thickness in individuals at high risk for depression, and extend the findings to include an association between R/S importance and greater pial surface area. Moreover, the findings suggest these cortical changes may confer protective benefits to religious/spiritual individuals at high risk for depression.

Authors+Show Affiliations

Department of Psychiatry, College of Physicians and Surgeons, Columbia University, New York, NY, USA. Division of Epidemiology, New York State Psychiatric Institute, New York, NY, USA.Department of Psychiatry, College of Physicians and Surgeons, Columbia University, New York, NY, USA.Department of Psychiatry, College of Physicians and Surgeons, Columbia University, New York, NY, USA. Division of Epidemiology, New York State Psychiatric Institute, New York, NY, USA. Mailman School of Public Health, Columbia University, New York, NY, USA.Department of Psychiatry, College of Physicians and Surgeons, Columbia University, New York, NY, USA. Division of Child and Adolescent Psychiatry, New York State Psychiatric Institute, New York, NY, USA.Department of Psychiatry, College of Physicians and Surgeons, Columbia University, New York, NY, USA. Division of Epidemiology, New York State Psychiatric Institute, New York, NY, USA.Department of Psychiatry, College of Physicians and Surgeons, Columbia University, New York, NY, USA. Division of Cognitive Neuroscience, New York State Psychiatric Institute, New York, NY, USA.Department of Psychiatry, College of Physicians and Surgeons, Columbia University, New York, NY, USA. Division of Cognitive Neuroscience, New York State Psychiatric Institute, New York, NY, USA.Division of Epidemiology, New York State Psychiatric Institute, New York, NY, USA.Department of Psychiatry, College of Physicians and Surgeons, Columbia University, New York, NY, USA. Division of Epidemiology, New York State Psychiatric Institute, New York, NY, USA.Teachers College, Columbia University, New York, NY.Department of Psychiatry, College of Physicians and Surgeons, Columbia University, New York, NY, USA. Division of Epidemiology, New York State Psychiatric Institute, New York, NY, USA. Mailman School of Public Health, Columbia University, New York, NY, USA.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

28642885

Citation

Svob, Connie, et al. "Neuroanatomical Correlates of Familial Risk-for-depression and Religiosity/spirituality." Spirituality in Clinical Practice (Washington, D.C.), vol. 4, no. 1, 2017, pp. 32-42.
Svob C, Liu J, Wickramaratne P, et al. Neuroanatomical correlates of familial risk-for-depression and religiosity/spirituality. Spiritual Clin Pract (Wash D C). 2017;4(1):32-42.
Svob, C., Liu, J., Wickramaratne, P., Hao, X., Talati, A., Kayser, J., ... Weissman, M. M. (2017). Neuroanatomical correlates of familial risk-for-depression and religiosity/spirituality. Spirituality in Clinical Practice (Washington, D.C.), 4(1), pp. 32-42. doi:10.1037/scp0000123.
Svob C, et al. Neuroanatomical Correlates of Familial Risk-for-depression and Religiosity/spirituality. Spiritual Clin Pract (Wash D C). 2017;4(1):32-42. PubMed PMID: 28642885.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Neuroanatomical correlates of familial risk-for-depression and religiosity/spirituality. AU - Svob,Connie, AU - Liu,Jie, AU - Wickramaratne,Priya, AU - Hao,Xuejun, AU - Talati,Ardesheer, AU - Kayser,Jürgen, AU - Tenke,Craig, AU - Warner,Virginia, AU - Yang,Jie, AU - Anderson,Micheline, AU - Weissman,Myrna M, PY - 2017/6/24/entrez PY - 2017/6/24/pubmed PY - 2017/6/24/medline KW - cortical thickness KW - depression KW - functional magnetic imaging (MRI) KW - pial surface KW - religion/spirituality SP - 32 EP - 42 JF - Spirituality in clinical practice (Washington, D.C.) JO - Spiritual Clin Pract (Wash D C) VL - 4 IS - 1 N2 - OBJECTIVE: To examine potential neural substrates that underlie the interplay between religiosity/spirituality and risk-for-depression. A new wave of data from a longitudinal, three generation study of individuals at high risk for depression is presented. In addition to providing new longitudinal data, we extend previous findings by employing additional (surface-based) methods for examining cortical volume. MEASURES PARTICIPANTS AND METHODS: Magnetic resonance imaging (MRI) scans were collected on 106 second and third generation family members at high or low risk for major depression defined by the presence or absence of depression in the first generation. Religiosity/spirituality measures were collected at the same time as the MRI scans and comprised self-report ratings of personal religious/spiritual (R/S) importance and frequency of religious attendance. Analyses were carried out with Freesurfer. Interactive effects of religiosity/spirituality and risk-for-depression were examined on measures of cortical thickness and cortical surface area. RESULTS: A high degree of belief in the importance of religion/spirituality was associated with both a thicker cortex and a larger pial surface area in persons at high risk for familial depression. No significant association was found between cortical regions and religious attendance in either risk group. CONCLUSIONS AND RELEVANCE: The results support previous findings of an association between R/S importance and cortical thickness in individuals at high risk for depression, and extend the findings to include an association between R/S importance and greater pial surface area. Moreover, the findings suggest these cortical changes may confer protective benefits to religious/spiritual individuals at high risk for depression. SN - 2326-4500 UR - https://www.unboundmedicine.com/medline/citation/28642885/Neuroanatomical_correlates_of_familial_risk_for_depression_and_religiosity/spirituality_ L2 - https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/28642885/ DB - PRIME DP - Unbound Medicine ER -