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[Nutrition physiology studies with formula diets: metabolism of multiple unsaturated fatty acids and prostaglandin biosynthesis in the human].
Klin Wochenschr. 1985 Aug 16; 63(16):731-9.KW

Abstract

Linoleic and linolenic acids are precursors for the biosynthesis of prostaglandins (PG) and related compounds. In man augmented linoleic acid intake results in stimulation of PG-biosynthesis, for PG originating from the kidney a stimulation only is found for PGE2. Dietary linolenic acid inhibits PG biosynthesis to a tenfold lesser degree than eicosapentaenoic acid. Renal PGE2 is depressed by linolenic acid intake, while no effect is found for PGF2 alpha up to 8 energy% of linolenic acid supply. Linoleic and linolenic acids additionally display effects on fatty acid metabolism. In contrast to the results of in vitro studies the supply with the precursor linoleic acid results in a decrease of arachidonic acid in cholesterolesters of plasma and in HDL-lecithin, while the intake of linolenic acid is without effect. From these data it is concluded that in vivo the conversion of linoleic to arachidonic acid occurs preferentially to the analogous conversion of linolenic to eicosapentaenoic acid.

Authors

No affiliation info available

Pub Type(s)

English Abstract
Journal Article
Research Support, Non-U.S. Gov't

Language

ger

PubMed ID

2864469

Citation

Adam, O. "[Nutrition Physiology Studies With Formula Diets: Metabolism of Multiple Unsaturated Fatty Acids and Prostaglandin Biosynthesis in the Human]." Klinische Wochenschrift, vol. 63, no. 16, 1985, pp. 731-9.
Adam O. [Nutrition physiology studies with formula diets: metabolism of multiple unsaturated fatty acids and prostaglandin biosynthesis in the human]. Klin Wochenschr. 1985;63(16):731-9.
Adam, O. (1985). [Nutrition physiology studies with formula diets: metabolism of multiple unsaturated fatty acids and prostaglandin biosynthesis in the human]. Klinische Wochenschrift, 63(16), 731-9.
Adam O. [Nutrition Physiology Studies With Formula Diets: Metabolism of Multiple Unsaturated Fatty Acids and Prostaglandin Biosynthesis in the Human]. Klin Wochenschr. 1985 Aug 16;63(16):731-9. PubMed PMID: 2864469.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Nutrition physiology studies with formula diets: metabolism of multiple unsaturated fatty acids and prostaglandin biosynthesis in the human]. A1 - Adam,O, PY - 1985/8/16/pubmed PY - 1985/8/16/medline PY - 1985/8/16/entrez SP - 731 EP - 9 JF - Klinische Wochenschrift JO - Klin Wochenschr VL - 63 IS - 16 N2 - Linoleic and linolenic acids are precursors for the biosynthesis of prostaglandins (PG) and related compounds. In man augmented linoleic acid intake results in stimulation of PG-biosynthesis, for PG originating from the kidney a stimulation only is found for PGE2. Dietary linolenic acid inhibits PG biosynthesis to a tenfold lesser degree than eicosapentaenoic acid. Renal PGE2 is depressed by linolenic acid intake, while no effect is found for PGF2 alpha up to 8 energy% of linolenic acid supply. Linoleic and linolenic acids additionally display effects on fatty acid metabolism. In contrast to the results of in vitro studies the supply with the precursor linoleic acid results in a decrease of arachidonic acid in cholesterolesters of plasma and in HDL-lecithin, while the intake of linolenic acid is without effect. From these data it is concluded that in vivo the conversion of linoleic to arachidonic acid occurs preferentially to the analogous conversion of linolenic to eicosapentaenoic acid. SN - 0023-2173 UR - https://www.unboundmedicine.com/medline/citation/2864469/[Nutrition_physiology_studies_with_formula_diets:_metabolism_of_multiple_unsaturated_fatty_acids_and_prostaglandin_biosynthesis_in_the_human]_ L2 - https://www.lens.org/lens/search/patent/list?q=citation_id:2864469 DB - PRIME DP - Unbound Medicine ER -