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Dietary Fat and Risk of Cardiovascular Disease: Recent Controversies and Advances.
Annu Rev Nutr. 2017 08 21; 37:423-446.AR

Abstract

Health effects of dietary fats have been extensively studied for decades. However, controversies exist on the effects of various types of fatty acids, especially saturated fatty acid (SFA), on cardiovascular disease (CVD). Current evidence supports that different types of dietary fatty acids have divergent effects on CVD risk, and the effects also depend strongly on the comparison or replacement macronutrient. A significant reduction in CVD risk can be achieved if SFAs are replaced by unsaturated fats, especially polyunsaturated fatty acids. Intake of industrially produced trans fat is consistently associated with higher CVD risk. Both n-6 and n-3 polyunsaturated fatty acids are associated with lower CVD risk, although the effects of fish oil supplementation remains inconsistent. The 2015-2020 Dietary Guidelines for Americans place greater emphasis on types of dietary fat than total amount of dietary fat and recommend replacing SFAs with unsaturated fats, especially polyunsaturated fatty acids for CVD prevention.

Authors+Show Affiliations

Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, Massachusetts 02115; email: nhbfh@channing.harvard.edu.Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, Massachusetts 02115; email: nhbfh@channing.harvard.edu. Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts 02115. Channing Division for Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts 02115.

Pub Type(s)

Journal Article
Review
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

28645222

Citation

Wang, Dong D., and Frank B. Hu. "Dietary Fat and Risk of Cardiovascular Disease: Recent Controversies and Advances." Annual Review of Nutrition, vol. 37, 2017, pp. 423-446.
Wang DD, Hu FB. Dietary Fat and Risk of Cardiovascular Disease: Recent Controversies and Advances. Annu Rev Nutr. 2017;37:423-446.
Wang, D. D., & Hu, F. B. (2017). Dietary Fat and Risk of Cardiovascular Disease: Recent Controversies and Advances. Annual Review of Nutrition, 37, 423-446. https://doi.org/10.1146/annurev-nutr-071816-064614
Wang DD, Hu FB. Dietary Fat and Risk of Cardiovascular Disease: Recent Controversies and Advances. Annu Rev Nutr. 2017 08 21;37:423-446. PubMed PMID: 28645222.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Dietary Fat and Risk of Cardiovascular Disease: Recent Controversies and Advances. AU - Wang,Dong D, AU - Hu,Frank B, Y1 - 2017/06/23/ PY - 2017/6/25/pubmed PY - 2017/10/3/medline PY - 2017/6/25/entrez KW - cardiovascular disease KW - diet KW - fat KW - monounsaturated fatty acids KW - polyunsaturated fatty acids KW - saturated fatty acids KW - trans fatty acids SP - 423 EP - 446 JF - Annual review of nutrition JO - Annu Rev Nutr VL - 37 N2 - Health effects of dietary fats have been extensively studied for decades. However, controversies exist on the effects of various types of fatty acids, especially saturated fatty acid (SFA), on cardiovascular disease (CVD). Current evidence supports that different types of dietary fatty acids have divergent effects on CVD risk, and the effects also depend strongly on the comparison or replacement macronutrient. A significant reduction in CVD risk can be achieved if SFAs are replaced by unsaturated fats, especially polyunsaturated fatty acids. Intake of industrially produced trans fat is consistently associated with higher CVD risk. Both n-6 and n-3 polyunsaturated fatty acids are associated with lower CVD risk, although the effects of fish oil supplementation remains inconsistent. The 2015-2020 Dietary Guidelines for Americans place greater emphasis on types of dietary fat than total amount of dietary fat and recommend replacing SFAs with unsaturated fats, especially polyunsaturated fatty acids for CVD prevention. SN - 1545-4312 UR - https://www.unboundmedicine.com/medline/citation/28645222/Dietary_Fat_and_Risk_of_Cardiovascular_Disease:_Recent_Controversies_and_Advances_ L2 - https://arjournals.annualreviews.org/doi/10.1146/annurev-nutr-071816-064614?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -