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Autism Spectrum Symptoms in a Tourette's Disorder Sample.
J Am Acad Child Adolesc Psychiatry. 2017 Jul; 56(7):610-617.e1.JA

Abstract

OBJECTIVE

Tourette's disorder (TD) and autism spectrum disorder (ASD) share clinical features and possibly an overlapping etiology. The aims of this study were to examine ASD symptom rates in participants with TD, and to characterize the relationships between ASD symptom patterns and TD, obsessive-compulsive disorder (OCD), and attention-deficit/hyperactivity disorder (ADHD).

METHOD

Participants with TD (n = 535) and their family members (n =234) recruited for genetic studies reported TD, OCD, and ADHD symptoms and completed the Social Responsiveness Scale Second Edition (SRS), which was used to characterize ASD symptoms.

RESULTS

SRS scores in participants with TD were similar to those observed in other clinical samples but lower than in ASD samples (mean SRS total raw score = 51; SD = 32.4). More children with TD met cut-off criteria for ASD (22.8%) than adults with TD (8.7%). The elevated rate in children was primarily due to high scores on the SRS Repetitive and Restricted Behaviors (RRB) subscale. Total SRS scores were correlated with TD (r = 0.27), OCD (r = 0.37), and ADHD (r = 0.44) and were higher among individuals with OCD symptom-based phenotypes than for those with tics alone.

CONCLUSION

Higher observed rates of ASD among children affected by TD may in part be due to difficulty in discriminating complex tics and OCD symptoms from ASD symptoms. Careful examination of ASD-specific symptom patterns (social communication vs. repetitive behaviors) is essential. Independent of ASD, the SRS may be a useful tool for identifying patients with TD with impairments in social communication that potentially place them at risk for bullying and other negative sequelae.

Authors+Show Affiliations

University of California, San Francisco.Johns Hopkins University School of Medicine, Baltimore.University of Toronto and University Health Network, and Youthdale Treatment Centers, Ontario, Canada.University of California, San Francisco.Psychiatric and Neurodevelopmental Genetics Unit, Massachusetts General Hospital, Boston.Psychiatric and Neurodevelopmental Genetics Unit, Massachusetts General Hospital, Boston.University of Montreal, Quebec, Canada.Yale Child Study Center, Yale University School of Medicine, New Haven, CT.Psychiatric and Neurodevelopmental Genetics Unit, Massachusetts General Hospital, Boston.North Shore/Long Island Jewish Health System, Feinstein Institute for Medical Research, Manhasset, NY.University of Groningen, University Medical Center Groningen; Utrecht University; and Drenthe Mental Health Institution, Assen, the Netherlands.Psychiatric and Neurodevelopmental Genetics Unit, Massachusetts General Hospital, Boston.Stanley Institute for Cognitive Genomics, Cold Spring Harbor Laboratory, Cold Spring Harbor, NY.University of Utah, Salt Lake City.Tripler Army Medical Center, Honolulu.University of California, San Francisco.Psychiatric and Neurodevelopmental Genetics Unit, Massachusetts General Hospital, Boston; Massachusetts General and Brigham and Women's Hospitals, Boston.University of Florida, Gainesville. Electronic address: carolmathews@ufl.edu.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

28647013

Citation

Darrow, Sabrina M., et al. "Autism Spectrum Symptoms in a Tourette's Disorder Sample." Journal of the American Academy of Child and Adolescent Psychiatry, vol. 56, no. 7, 2017, pp. 610-617.e1.
Darrow SM, Grados M, Sandor P, et al. Autism Spectrum Symptoms in a Tourette's Disorder Sample. J Am Acad Child Adolesc Psychiatry. 2017;56(7):610-617.e1.
Darrow, S. M., Grados, M., Sandor, P., Hirschtritt, M. E., Illmann, C., Osiecki, L., Dion, Y., King, R., Pauls, D., Budman, C. L., Cath, D. C., Greenberg, E., Lyon, G. J., McMahon, W. M., Lee, P. C., Delucchi, K. L., Scharf, J. M., & Mathews, C. A. (2017). Autism Spectrum Symptoms in a Tourette's Disorder Sample. Journal of the American Academy of Child and Adolescent Psychiatry, 56(7), 610-e1. https://doi.org/10.1016/j.jaac.2017.05.002
Darrow SM, et al. Autism Spectrum Symptoms in a Tourette's Disorder Sample. J Am Acad Child Adolesc Psychiatry. 2017;56(7):610-617.e1. PubMed PMID: 28647013.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Autism Spectrum Symptoms in a Tourette's Disorder Sample. AU - Darrow,Sabrina M, AU - Grados,Marco, AU - Sandor,Paul, AU - Hirschtritt,Matthew E, AU - Illmann,Cornelia, AU - Osiecki,Lisa, AU - Dion,Yves, AU - King,Robert, AU - Pauls,David, AU - Budman,Cathy L, AU - Cath,Danielle C, AU - Greenberg,Erica, AU - Lyon,Gholson J, AU - McMahon,William M, AU - Lee,Paul C, AU - Delucchi,Kevin L, AU - Scharf,Jeremiah M, AU - Mathews,Carol A, Y1 - 2017/05/11/ PY - 2016/11/28/received PY - 2017/04/11/revised PY - 2017/05/05/accepted PY - 2017/6/26/entrez PY - 2017/6/26/pubmed PY - 2018/3/28/medline KW - Tourette's disorder KW - attention-deficit/hyperactivity disorder KW - autism KW - heritability KW - obsessive-compulsive disorder SP - 610 EP - 617.e1 JF - Journal of the American Academy of Child and Adolescent Psychiatry JO - J Am Acad Child Adolesc Psychiatry VL - 56 IS - 7 N2 - OBJECTIVE: Tourette's disorder (TD) and autism spectrum disorder (ASD) share clinical features and possibly an overlapping etiology. The aims of this study were to examine ASD symptom rates in participants with TD, and to characterize the relationships between ASD symptom patterns and TD, obsessive-compulsive disorder (OCD), and attention-deficit/hyperactivity disorder (ADHD). METHOD: Participants with TD (n = 535) and their family members (n =234) recruited for genetic studies reported TD, OCD, and ADHD symptoms and completed the Social Responsiveness Scale Second Edition (SRS), which was used to characterize ASD symptoms. RESULTS: SRS scores in participants with TD were similar to those observed in other clinical samples but lower than in ASD samples (mean SRS total raw score = 51; SD = 32.4). More children with TD met cut-off criteria for ASD (22.8%) than adults with TD (8.7%). The elevated rate in children was primarily due to high scores on the SRS Repetitive and Restricted Behaviors (RRB) subscale. Total SRS scores were correlated with TD (r = 0.27), OCD (r = 0.37), and ADHD (r = 0.44) and were higher among individuals with OCD symptom-based phenotypes than for those with tics alone. CONCLUSION: Higher observed rates of ASD among children affected by TD may in part be due to difficulty in discriminating complex tics and OCD symptoms from ASD symptoms. Careful examination of ASD-specific symptom patterns (social communication vs. repetitive behaviors) is essential. Independent of ASD, the SRS may be a useful tool for identifying patients with TD with impairments in social communication that potentially place them at risk for bullying and other negative sequelae. SN - 1527-5418 UR - https://www.unboundmedicine.com/medline/citation/28647013/ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0890-8567(17)30204-6 DB - PRIME DP - Unbound Medicine ER -