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Seasonal influenza vaccine effectiveness against laboratory-confirmed influenza hospitalizations - Latin America, 2013.
Vaccine. 2018 06 07; 36(24):3555-3566.V

Abstract

BACKGROUND

Despite widespread utilization of influenza vaccines, effectiveness (VE) has not been routinely measured in Latin America.

METHODS

We used a case test-negative control design to estimate trivalent inactivated influenza VE against laboratory-confirmed influenza among hospitalized children aged 6months-5years and adults aged ≥60years which are age-groups targeted for vaccination. We sought persons with severe acute respiratory infections (SARI), hospitalized at 71 sentinel hospitals in Argentina, Brazil, Chile, Colombia, Costa Rica, El Salvador, Honduras, Panama, and Paraguay during January-December 2013. Cases had an influenza virus infection confirmed by real-time reverse transcription PCR (rRT-PCR); controls had a negative rRT-PCR result for influenza viruses. We used a two-stage random effects model to estimate pooled VE per target age-group, adjusting for the month of illness onset, age and preexisting medical conditions.

RESULTS

We identified 2620 SARI patients across sites: 246 influenza cases and 720 influenza-negative controls aged ≤5years and 448 cases and 1206 controls aged ≥60years. The most commonly identified subtype among participants (48%) was the influenza A(H1N1)pdm09 virus followed by influenza A(H3N2) (34%) and influenza B (18%) viruses. Among children, the adjusted VE of full vaccination (one dose for previously vaccinated or two if vaccine naïve) against any influenza virus SARI was 47% (95% confidence interval [CI]: 14-71%); VE was 58% (95% CI: 16-79%) against influenza A(H1N1)pdm09, and 65% (95% CI: -9; 89%) against influenza A(H3N2) viruses associated SARI. Crude VE of full vaccination against influenza B viruses associated SARI among children was 3% (95% CI: -150; 63). Among adults aged ≥60years, adjusted VE against any influenza SARI was 48% (95% CI: 34-60%); VE was 54% (95% CI: 37-69%) against influenza A(H1N1)pdm09, 43% (95% CI: 18-61%) against influenza A(H3N2) and 34% (95% CI: -4; 58%) against B viruses associated SARI.

CONCLUSION

Influenza vaccine provided moderate protection against severe influenza illness among fully vaccinated young children and older adults, supporting current vaccination strategies.

Authors+Show Affiliations

Department of Family Gender and Life Course/Immunization, Pan American Health Organization/World Health Organization (PAHO/WHO), Washington D.C., USA; Université Libre de Bruxelles, Ecole de Santé Publique, Brussels, Belgium. Electronic address: elomeirin@paho.org.US Centers for Disease Control and Prevention (CDC), Influenza Division, Atlanta, Georgia, USA.US Centers for Disease Control and Prevention (CDC), Influenza Division, Atlanta, Georgia, USA.No affiliation info availableCDC, El Salvador.Department of Communicable Diseases and Health Analysis, PAHO/WHO, Washington D.C., USA.Department of Communicable Diseases and Health Analysis, PAHO/WHO, Washington D.C., USA.US Centers for Disease Control and Prevention (CDC), Influenza Division, Atlanta, Georgia, USA.Department of Family Gender and Life Course/Immunization, Pan American Health Organization/World Health Organization (PAHO/WHO), Washington D.C., USA.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.

Language

eng

PubMed ID

28648543

Citation

El Omeiri, Nathalie, et al. "Seasonal Influenza Vaccine Effectiveness Against Laboratory-confirmed Influenza Hospitalizations - Latin America, 2013." Vaccine, vol. 36, no. 24, 2018, pp. 3555-3566.
El Omeiri N, Azziz-Baumgartner E, Thompson MG, et al. Seasonal influenza vaccine effectiveness against laboratory-confirmed influenza hospitalizations - Latin America, 2013. Vaccine. 2018;36(24):3555-3566.
El Omeiri, N., Azziz-Baumgartner, E., Thompson, M. G., Clará, W., Cerpa, M., Palekar, R., Mirza, S., & Ropero-Álvarez, A. M. (2018). Seasonal influenza vaccine effectiveness against laboratory-confirmed influenza hospitalizations - Latin America, 2013. Vaccine, 36(24), 3555-3566. https://doi.org/10.1016/j.vaccine.2017.06.036
El Omeiri N, et al. Seasonal Influenza Vaccine Effectiveness Against Laboratory-confirmed Influenza Hospitalizations - Latin America, 2013. Vaccine. 2018 06 7;36(24):3555-3566. PubMed PMID: 28648543.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Seasonal influenza vaccine effectiveness against laboratory-confirmed influenza hospitalizations - Latin America, 2013. AU - El Omeiri,Nathalie, AU - Azziz-Baumgartner,Eduardo, AU - Thompson,Mark G, AU - ,, AU - Clará,Wilfrido, AU - Cerpa,Mauricio, AU - Palekar,Rakhee, AU - Mirza,Sara, AU - Ropero-Álvarez,Alba María, Y1 - 2017/06/23/ PY - 2017/02/28/received PY - 2017/06/12/revised PY - 2017/06/13/accepted PY - 2017/6/27/pubmed PY - 2018/9/27/medline PY - 2017/6/27/entrez KW - Adults KW - Children KW - Influenza KW - Influenza vaccines KW - International KW - Vaccine effectiveness SP - 3555 EP - 3566 JF - Vaccine JO - Vaccine VL - 36 IS - 24 N2 - BACKGROUND: Despite widespread utilization of influenza vaccines, effectiveness (VE) has not been routinely measured in Latin America. METHODS: We used a case test-negative control design to estimate trivalent inactivated influenza VE against laboratory-confirmed influenza among hospitalized children aged 6months-5years and adults aged ≥60years which are age-groups targeted for vaccination. We sought persons with severe acute respiratory infections (SARI), hospitalized at 71 sentinel hospitals in Argentina, Brazil, Chile, Colombia, Costa Rica, El Salvador, Honduras, Panama, and Paraguay during January-December 2013. Cases had an influenza virus infection confirmed by real-time reverse transcription PCR (rRT-PCR); controls had a negative rRT-PCR result for influenza viruses. We used a two-stage random effects model to estimate pooled VE per target age-group, adjusting for the month of illness onset, age and preexisting medical conditions. RESULTS: We identified 2620 SARI patients across sites: 246 influenza cases and 720 influenza-negative controls aged ≤5years and 448 cases and 1206 controls aged ≥60years. The most commonly identified subtype among participants (48%) was the influenza A(H1N1)pdm09 virus followed by influenza A(H3N2) (34%) and influenza B (18%) viruses. Among children, the adjusted VE of full vaccination (one dose for previously vaccinated or two if vaccine naïve) against any influenza virus SARI was 47% (95% confidence interval [CI]: 14-71%); VE was 58% (95% CI: 16-79%) against influenza A(H1N1)pdm09, and 65% (95% CI: -9; 89%) against influenza A(H3N2) viruses associated SARI. Crude VE of full vaccination against influenza B viruses associated SARI among children was 3% (95% CI: -150; 63). Among adults aged ≥60years, adjusted VE against any influenza SARI was 48% (95% CI: 34-60%); VE was 54% (95% CI: 37-69%) against influenza A(H1N1)pdm09, 43% (95% CI: 18-61%) against influenza A(H3N2) and 34% (95% CI: -4; 58%) against B viruses associated SARI. CONCLUSION: Influenza vaccine provided moderate protection against severe influenza illness among fully vaccinated young children and older adults, supporting current vaccination strategies. SN - 1873-2518 UR - https://www.unboundmedicine.com/medline/citation/28648543/Seasonal_influenza_vaccine_effectiveness_against_laboratory_confirmed_influenza_hospitalizations___Latin_America_2013_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0264-410X(17)30823-X DB - PRIME DP - Unbound Medicine ER -