Tags

Type your tag names separated by a space and hit enter

Formulation and in vitro evaluation of sustained release matrix tablets using cross-linked natural gum.
Pak J Pharm Sci. 2017 Mar; 30(2):355-362.PJ

Abstract

Polysaccharide gums because of their biocompatibility, biodegradability and non-immunogenic properties are considered as the best choice for preparing sustained release tablets as compared to their synthetic counterpart. The cross linking of natural gums in matrix tablets increase the sustained release property of matrix tablets. Isoniazid is a first line therapy of tuberculosis, belongs to BCS I with half-life of 3-4 hours. These characteristics make isoniazid a good candidate for sustained release dosage form. Karaya gum crossed linked with trisodium tri metaphosphate was used as release rate retardant for preparing isoniazid cross-linked matrix tablet. Total 8 sustained release formulations were prepared. Both granules and tablets were evaluated under in vitro condition against different parameters. Dissolution studies were performed with all eight formulations for 12 hours using USP apparatus I. Four formulations designated as F1, F2, F3, F4 have drug and karaya gum while other four formulations F5, F6, F7, F8 have drug and crossed linked polymer in ratios of 1:1, 1:2, 1:3 and 1:4 respectively. Dissolution data was analyzed by using different kinetic models. Best fit model for most efficient formulation was zero order while release mechanism was super case I. Formulation 8 showed sufficiently slow release kinetics and about 83% of drug was released in 10 hours, indicating that cross-linked karaya gum proved efficient in preparing sustained release tablets.

Authors+Show Affiliations

Jamil QA
Institute of Pharmaceutical Sciences, University of Veterinary and Animal Sciences, Lahore, Pakistan / Drugs Regulatory Authority of Pakistan, Islamabad, Pakistan.
Masood MI
Institute of Pharmaceutical Sciences, University of Veterinary and Animal Sciences, Lahore, Pakistan.
Jamil MN
Faculty of Pharmacy, University of Sargodha, Sargodha, Pakistan.
Masood I
Faculty of Pharmacy and Alternative Medicine, Islamia University of Bahawalpur, Bahawalpur, Pakistan.
Iqbal SM
Drugs Regulatory Authority of Pakistan, Islamabad, Pakistan.

MeSH

Delayed-Action PreparationsDrug CompoundingDrug LiberationIn Vitro TechniquesIsoniazidKaraya GumKineticsPhosphatesTablets

Pub Type(s)

Journal Article

Language

eng

PubMed ID

28649056

Citation

Jamil, Qurratul Ain, et al. "Formulation and in Vitro Evaluation of Sustained Release Matrix Tablets Using Cross-linked Natural Gum." Pakistan Journal of Pharmaceutical Sciences, vol. 30, no. 2, 2017, pp. 355-362.
Jamil QA, Masood MI, Jamil MN, et al. Formulation and in vitro evaluation of sustained release matrix tablets using cross-linked natural gum. Pak J Pharm Sci. 2017;30(2):355-362.
Jamil, Q. A., Masood, M. I., Jamil, M. N., Masood, I., & Iqbal, S. M. (2017). Formulation and in vitro evaluation of sustained release matrix tablets using cross-linked natural gum. Pakistan Journal of Pharmaceutical Sciences, 30(2), 355-362.
Jamil QA, et al. Formulation and in Vitro Evaluation of Sustained Release Matrix Tablets Using Cross-linked Natural Gum. Pak J Pharm Sci. 2017;30(2):355-362. PubMed PMID: 28649056.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Formulation and in vitro evaluation of sustained release matrix tablets using cross-linked natural gum. AU - Jamil,Qurratul Ain, AU - Masood,Muhammad Irfan, AU - Jamil,Muhammad Nauman, AU - Masood,Imran, AU - Iqbal,Shahid Muhammad, PY - 2017/6/27/entrez PY - 2017/6/27/pubmed PY - 2019/7/2/medline SP - 355 EP - 362 JF - Pakistan journal of pharmaceutical sciences JO - Pak J Pharm Sci VL - 30 IS - 2 N2 - Polysaccharide gums because of their biocompatibility, biodegradability and non-immunogenic properties are considered as the best choice for preparing sustained release tablets as compared to their synthetic counterpart. The cross linking of natural gums in matrix tablets increase the sustained release property of matrix tablets. Isoniazid is a first line therapy of tuberculosis, belongs to BCS I with half-life of 3-4 hours. These characteristics make isoniazid a good candidate for sustained release dosage form. Karaya gum crossed linked with trisodium tri metaphosphate was used as release rate retardant for preparing isoniazid cross-linked matrix tablet. Total 8 sustained release formulations were prepared. Both granules and tablets were evaluated under in vitro condition against different parameters. Dissolution studies were performed with all eight formulations for 12 hours using USP apparatus I. Four formulations designated as F1, F2, F3, F4 have drug and karaya gum while other four formulations F5, F6, F7, F8 have drug and crossed linked polymer in ratios of 1:1, 1:2, 1:3 and 1:4 respectively. Dissolution data was analyzed by using different kinetic models. Best fit model for most efficient formulation was zero order while release mechanism was super case I. Formulation 8 showed sufficiently slow release kinetics and about 83% of drug was released in 10 hours, indicating that cross-linked karaya gum proved efficient in preparing sustained release tablets. SN - 1011-601X UR - https://www.unboundmedicine.com/medline/citation/28649056/Formulation_and_in_vitro_evaluation_of_sustained_release_matrix_tablets_using_cross_linked_natural_gum_ DB - PRIME DP - Unbound Medicine ER -