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Phorbol ester inhibition of hormonal induction of tyrosine aminotransferase.
Biochem Biophys Res Commun. 1985 Sep 16; 131(2):815-20.BB

Abstract

The liver specific enzyme, tyrosine aminotransferase, can be induced by glucocorticoids, cAMP analogs, or insulin. Each of these different inducing agents is believed to act through a separate pathway. The tumor promoting phorbol esters have been reported to stimulate phosphorylation of the insulin receptor and thereby decrease the ability of insulin to induce tyrosine aminotransferase. Our results demonstrate that TPA will not only inhibit the insulin stimulated increase in tyrosine aminotransferase, but will also inhibit induction of the enzyme by glucocorticoids or by cAMP.

Authors

Koontz JW
No affiliation info available
Goodman S
No affiliation info available

MeSH

AnimalsBucladesineCell LineDexamethasoneDose-Response Relationship, DrugEnzyme InductionInsulinLiver Neoplasms, ExperimentalPhorbolsTetradecanoylphorbol AcetateTyrosine Transaminase

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

2864925

Citation

Koontz, J W., and S Goodman. "Phorbol Ester Inhibition of Hormonal Induction of Tyrosine Aminotransferase." Biochemical and Biophysical Research Communications, vol. 131, no. 2, 1985, pp. 815-20.
Koontz JW, Goodman S. Phorbol ester inhibition of hormonal induction of tyrosine aminotransferase. Biochem Biophys Res Commun. 1985;131(2):815-20.
Koontz, J. W., & Goodman, S. (1985). Phorbol ester inhibition of hormonal induction of tyrosine aminotransferase. Biochemical and Biophysical Research Communications, 131(2), 815-20.
Koontz JW, Goodman S. Phorbol Ester Inhibition of Hormonal Induction of Tyrosine Aminotransferase. Biochem Biophys Res Commun. 1985 Sep 16;131(2):815-20. PubMed PMID: 2864925.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Phorbol ester inhibition of hormonal induction of tyrosine aminotransferase. AU - Koontz,J W, AU - Goodman,S, PY - 1985/9/16/pubmed PY - 1985/9/16/medline PY - 1985/9/16/entrez SP - 815 EP - 20 JF - Biochemical and biophysical research communications JO - Biochem Biophys Res Commun VL - 131 IS - 2 N2 - The liver specific enzyme, tyrosine aminotransferase, can be induced by glucocorticoids, cAMP analogs, or insulin. Each of these different inducing agents is believed to act through a separate pathway. The tumor promoting phorbol esters have been reported to stimulate phosphorylation of the insulin receptor and thereby decrease the ability of insulin to induce tyrosine aminotransferase. Our results demonstrate that TPA will not only inhibit the insulin stimulated increase in tyrosine aminotransferase, but will also inhibit induction of the enzyme by glucocorticoids or by cAMP. SN - 0006-291X UR - https://www.unboundmedicine.com/medline/citation/2864925/Phorbol_ester_inhibition_of_hormonal_induction_of_tyrosine_aminotransferase_ DB - PRIME DP - Unbound Medicine ER -