Tags

Type your tag names separated by a space and hit enter

Terminalia bellirica (Gaertn.) Roxb. fruit mitigates CCl4 induced oxidative stress and hepatotoxicity in rats.
Biomed Pharmacother 2017; 93:327-333BP

Abstract

Terminalia bellirica (Gaertn.) Roxb. is a medicinal plant used for the treatment of various ailments in the traditional system of medicine like Ayurveda where it has been prescribed as a rejuvenator and general health tonic. The fruit of the plant is one of the components of the age old ayurvedic formulation-'Triphala'. The present study evaluates curative effect of aqueous acetone extract of Terminalia bellirica fruits (AATB) against CCl4 induced oxidative stress and liver damage in an animal model. Two doses of the fruit extract (200mg/kg body weight and 400mg/kg body weight) were investigated for the beneficial effects. At the end of the treatment, liver function markers (ALT, AST, ALP, GGT, LDH, total bilirubin, total protein, albumin, globulin, albumin-globulin ratio) as well as hepatic oxidative stress markers (SOD, CAT, GSH) were evaluated. Treatment with AATB significantly restored the parameters towards normal level as compared to the elevated biochemical markers in the CCl4 treated animals. Reversal to normal tissue architecture was observed in histological evaluation. The results of AATB (400mg/kg) were found comparable with that of standard drug silymarin in all the parameters. The above findings suggest the therapeutic potential of the plant in alleviating hepatic oxidative stress and tissue damage, hence the traditional use of the plant in this regard stands justified.

Authors+Show Affiliations

School of Biosciences, Mahatma Gandhi University, Priyadarshini Hills, Kottayam, Kerala, India.School of Biosciences, Mahatma Gandhi University, Priyadarshini Hills, Kottayam, Kerala, India.School of Biosciences, Mahatma Gandhi University, Priyadarshini Hills, Kottayam, Kerala, India.School of Biosciences, Mahatma Gandhi University, Priyadarshini Hills, Kottayam, Kerala, India.School of Biosciences, Mahatma Gandhi University, Priyadarshini Hills, Kottayam, Kerala, India. Electronic address: mslathasbs@yahoo.com.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

28651233

Citation

Kuriakose, Jayesh, et al. "Terminalia Bellirica (Gaertn.) Roxb. Fruit Mitigates CCl4 Induced Oxidative Stress and Hepatotoxicity in Rats." Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie, vol. 93, 2017, pp. 327-333.
Kuriakose J, Lal Raisa H, A V, et al. Terminalia bellirica (Gaertn.) Roxb. fruit mitigates CCl4 induced oxidative stress and hepatotoxicity in rats. Biomed Pharmacother. 2017;93:327-333.
Kuriakose, J., Lal Raisa, H., A, V., Eldhose, B., & M S, L. (2017). Terminalia bellirica (Gaertn.) Roxb. fruit mitigates CCl4 induced oxidative stress and hepatotoxicity in rats. Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie, 93, pp. 327-333. doi:10.1016/j.biopha.2017.06.080.
Kuriakose J, et al. Terminalia Bellirica (Gaertn.) Roxb. Fruit Mitigates CCl4 Induced Oxidative Stress and Hepatotoxicity in Rats. Biomed Pharmacother. 2017;93:327-333. PubMed PMID: 28651233.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Terminalia bellirica (Gaertn.) Roxb. fruit mitigates CCl4 induced oxidative stress and hepatotoxicity in rats. AU - Kuriakose,Jayesh, AU - Lal Raisa,Helen, AU - A,Vysakh, AU - Eldhose,Binil, AU - M S,Latha, Y1 - 2017/06/24/ PY - 2017/04/18/received PY - 2017/05/31/revised PY - 2017/06/20/accepted PY - 2017/6/27/pubmed PY - 2018/4/25/medline PY - 2017/6/27/entrez KW - Carbon tetrachloride KW - Hepatic injury KW - Oxidative stress KW - Terminalia bellirica fruit SP - 327 EP - 333 JF - Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie JO - Biomed. Pharmacother. VL - 93 N2 - Terminalia bellirica (Gaertn.) Roxb. is a medicinal plant used for the treatment of various ailments in the traditional system of medicine like Ayurveda where it has been prescribed as a rejuvenator and general health tonic. The fruit of the plant is one of the components of the age old ayurvedic formulation-'Triphala'. The present study evaluates curative effect of aqueous acetone extract of Terminalia bellirica fruits (AATB) against CCl4 induced oxidative stress and liver damage in an animal model. Two doses of the fruit extract (200mg/kg body weight and 400mg/kg body weight) were investigated for the beneficial effects. At the end of the treatment, liver function markers (ALT, AST, ALP, GGT, LDH, total bilirubin, total protein, albumin, globulin, albumin-globulin ratio) as well as hepatic oxidative stress markers (SOD, CAT, GSH) were evaluated. Treatment with AATB significantly restored the parameters towards normal level as compared to the elevated biochemical markers in the CCl4 treated animals. Reversal to normal tissue architecture was observed in histological evaluation. The results of AATB (400mg/kg) were found comparable with that of standard drug silymarin in all the parameters. The above findings suggest the therapeutic potential of the plant in alleviating hepatic oxidative stress and tissue damage, hence the traditional use of the plant in this regard stands justified. SN - 1950-6007 UR - https://www.unboundmedicine.com/medline/citation/28651233/Terminalia_bellirica_(Gaertn.)_Roxb._fruit_mitigates_CCl4_induced_oxidative_stress_and_hepatotoxicity_in_rats L2 - https://linkinghub.elsevier.com/retrieve/pii/S0753-3322(17)31876-0 DB - PRIME DP - Unbound Medicine ER -