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Repeated treatment with reserpine as a progressive animal model of depression.
Pak J Pharm Sci 2017; 30(3):897-902PJ

Abstract

Treatment-resistant depression is a major health problem worldwide. Restricted validity of the existing animal models of depression along with the need for the study of progressive development of resistance to antidepressants, demands the modeling of a progressive animal model of depression. Present study was designed to test the hypothesis that the repeated administration of reserpine could serve as a progressive animal model of depression. Animals were injected with reserpine (1.0mg/kg; once a day) for three weeks. Results from the present study showed impaired locomotive effects of reserpine in Skinner's box following second as well as third week. These hypolocomotive effects were more pronounced after third week than the second week. Reserpine-induced behavioral depression was evident in the animals after 2 weeks, as assessed by using forced swim test. Depletion of 5-HT, dopamine and metabolites was also observed in the brain samples. Results from the present study suggest that repeated administration of reserpine could be serve as a progressive model of depression and could be used as a convenient and economic animal model for the face validity of anxiolytic compounds. Findings have potential implications with reference to the understanding and the management of treatment-resistant depression.

Authors+Show Affiliations

Neurochemistry and Biochemical Neuropharmacology Research Unit, Department of Biochemistry, University of Karachi, Pakistan.Neurochemistry and Biochemical Neuropharmacology Research Unit, Department of Biochemistry, University of Karachi, Pakistan / Neuroscience Research Laboratory, Dr. Panjwani Center for Molecular Medicine and Drug Research, University of Karachi, Pakistan.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

28653936

Citation

Ikram, Huma, and Darakhshan J. Haleem. "Repeated Treatment With Reserpine as a Progressive Animal Model of Depression." Pakistan Journal of Pharmaceutical Sciences, vol. 30, no. 3, 2017, pp. 897-902.
Ikram H, Haleem DJ. Repeated treatment with reserpine as a progressive animal model of depression. Pak J Pharm Sci. 2017;30(3):897-902.
Ikram, H., & Haleem, D. J. (2017). Repeated treatment with reserpine as a progressive animal model of depression. Pakistan Journal of Pharmaceutical Sciences, 30(3), pp. 897-902.
Ikram H, Haleem DJ. Repeated Treatment With Reserpine as a Progressive Animal Model of Depression. Pak J Pharm Sci. 2017;30(3):897-902. PubMed PMID: 28653936.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Repeated treatment with reserpine as a progressive animal model of depression. AU - Ikram,Huma, AU - Haleem,Darakhshan J, PY - 2017/6/28/entrez PY - 2017/6/28/pubmed PY - 2017/9/8/medline SP - 897 EP - 902 JF - Pakistan journal of pharmaceutical sciences JO - Pak J Pharm Sci VL - 30 IS - 3 N2 - Treatment-resistant depression is a major health problem worldwide. Restricted validity of the existing animal models of depression along with the need for the study of progressive development of resistance to antidepressants, demands the modeling of a progressive animal model of depression. Present study was designed to test the hypothesis that the repeated administration of reserpine could serve as a progressive animal model of depression. Animals were injected with reserpine (1.0mg/kg; once a day) for three weeks. Results from the present study showed impaired locomotive effects of reserpine in Skinner's box following second as well as third week. These hypolocomotive effects were more pronounced after third week than the second week. Reserpine-induced behavioral depression was evident in the animals after 2 weeks, as assessed by using forced swim test. Depletion of 5-HT, dopamine and metabolites was also observed in the brain samples. Results from the present study suggest that repeated administration of reserpine could be serve as a progressive model of depression and could be used as a convenient and economic animal model for the face validity of anxiolytic compounds. Findings have potential implications with reference to the understanding and the management of treatment-resistant depression. SN - 1011-601X UR - https://www.unboundmedicine.com/medline/citation/28653936/Repeated_treatment_with_reserpine_as_a_progressive_animal_model_of_depression_ L2 - https://medlineplus.gov/depression.html DB - PRIME DP - Unbound Medicine ER -