Tags

Type your tag names separated by a space and hit enter

Polygenic risk has an impact on the structural plasticity of hippocampal subfields during aerobic exercise combined with cognitive remediation in multi-episode schizophrenia.
Transl Psychiatry. 2017 06 27; 7(6):e1159.TP

Abstract

Preliminary studies suggest that, besides improving cognition, aerobic exercise might increase hippocampal volume in schizophrenia patients; however, results are not consistent. Individual mechanisms of volume changes are unknown but might be connected to the load of risk genes. Genome-wide association studies have uncovered the polygenic architecture of schizophrenia. The secondary analysis presented here aimed to determine the modulatory role of schizophrenia polygenic risk scores (PRSs) on volume changes in the total hippocampus and cornu ammonis (CA) 1, CA2/3, CA4/dentate gyrus (DG) and subiculum over time. We studied 20 multi-episode schizophrenia patients and 23 healthy controls who performed aerobic exercise (endurance training) combined with cognitive remediation for 3 months and 21 multi-episode schizophrenia patients allocated to a control intervention (table soccer) combined with cognitive remediation. Magnetic resonance imaging-based assessments were performed at baseline and after 3 months with FreeSurfer. No effects of PRSs were found on total hippocampal volume change. Subfield analyses showed that the volume changes between baseline and 3 months in the left CA4/DG were significantly influenced by PRSs in schizophrenia patients performing aerobic exercise. A larger genetic risk burden was associated with a less pronounced volume increase or a decrease in volume over the course of the exercise intervention. Results of exploratory enrichment analyses reinforced the notion of genetic risk factors modulating biological processes tightly related to synaptic ion channel activity, calcium signaling, glutamate signaling and regulation of cell morphogenesis. We hypothesize that a high polygenic risk may negatively influence neuroplasticity in CA4/DG during aerobic exercise in schizophrenia.

Authors+Show Affiliations

Department of Psychiatry and Psychotherapy, Ludwig Maximilian University Munich, Munich, Germany. Institute of Psychiatric Phenomics and Genomics (IPPG), Medical Center of the University of Munich, Munich, Germany.Department of Psychiatry and Psychotherapy, Ludwig Maximilian University Munich, Munich, Germany.Department of Psychiatry and Psychotherapy, Ludwig Maximilian University Munich, Munich, Germany. Institute of Clinical Radiology, Ludwig Maximilian University Munich, Munich, Germany.Department of Psychiatry and Psychotherapy, Ludwig Maximilian University Munich, Munich, Germany.Department of Psychiatry and Psychotherapy, Ludwig Maximilian University Munich, Munich, Germany.Institute of Human Genetics, University of Bonn, Bonn, Germany.Department of Psychiatry and Psychotherapy, Ludwig Maximilian University Munich, Munich, Germany.Department of Genetic Epidemiology, University Medical Center, Georg-August-Universität Göttingen, Göttingen, Germany.Department of Psychiatry and Psychotherapy, Ludwig Maximilian University Munich, Munich, Germany. Laboratory of Neuroscience, Institute of Psychiatry, University of Sao Paulo, Sao Paulo, Brazil.Department of Psychiatry and Psychotherapy, Ludwig Maximilian University Munich, Munich, Germany.Department of Psychiatry and Psychotherapy, Ludwig Maximilian University Munich, Munich, Germany.

Pub Type(s)

Clinical Trial
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

28654095

Citation

Papiol, S, et al. "Polygenic Risk Has an Impact On the Structural Plasticity of Hippocampal Subfields During Aerobic Exercise Combined With Cognitive Remediation in Multi-episode Schizophrenia." Translational Psychiatry, vol. 7, no. 6, 2017, pp. e1159.
Papiol S, Popovic D, Keeser D, et al. Polygenic risk has an impact on the structural plasticity of hippocampal subfields during aerobic exercise combined with cognitive remediation in multi-episode schizophrenia. Transl Psychiatry. 2017;7(6):e1159.
Papiol, S., Popovic, D., Keeser, D., Hasan, A., Schneider-Axmann, T., Degenhardt, F., Rossner, M. J., Bickeböller, H., Schmitt, A., Falkai, P., & Malchow, B. (2017). Polygenic risk has an impact on the structural plasticity of hippocampal subfields during aerobic exercise combined with cognitive remediation in multi-episode schizophrenia. Translational Psychiatry, 7(6), e1159. https://doi.org/10.1038/tp.2017.131
Papiol S, et al. Polygenic Risk Has an Impact On the Structural Plasticity of Hippocampal Subfields During Aerobic Exercise Combined With Cognitive Remediation in Multi-episode Schizophrenia. Transl Psychiatry. 2017 06 27;7(6):e1159. PubMed PMID: 28654095.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Polygenic risk has an impact on the structural plasticity of hippocampal subfields during aerobic exercise combined with cognitive remediation in multi-episode schizophrenia. AU - Papiol,S, AU - Popovic,D, AU - Keeser,D, AU - Hasan,A, AU - Schneider-Axmann,T, AU - Degenhardt,F, AU - Rossner,M J, AU - Bickeböller,H, AU - Schmitt,A, AU - Falkai,P, AU - Malchow,B, Y1 - 2017/06/27/ PY - 2017/03/03/received PY - 2017/05/12/revised PY - 2017/05/17/accepted PY - 2017/6/28/entrez PY - 2017/6/28/pubmed PY - 2018/3/27/medline SP - e1159 EP - e1159 JF - Translational psychiatry JO - Transl Psychiatry VL - 7 IS - 6 N2 - Preliminary studies suggest that, besides improving cognition, aerobic exercise might increase hippocampal volume in schizophrenia patients; however, results are not consistent. Individual mechanisms of volume changes are unknown but might be connected to the load of risk genes. Genome-wide association studies have uncovered the polygenic architecture of schizophrenia. The secondary analysis presented here aimed to determine the modulatory role of schizophrenia polygenic risk scores (PRSs) on volume changes in the total hippocampus and cornu ammonis (CA) 1, CA2/3, CA4/dentate gyrus (DG) and subiculum over time. We studied 20 multi-episode schizophrenia patients and 23 healthy controls who performed aerobic exercise (endurance training) combined with cognitive remediation for 3 months and 21 multi-episode schizophrenia patients allocated to a control intervention (table soccer) combined with cognitive remediation. Magnetic resonance imaging-based assessments were performed at baseline and after 3 months with FreeSurfer. No effects of PRSs were found on total hippocampal volume change. Subfield analyses showed that the volume changes between baseline and 3 months in the left CA4/DG were significantly influenced by PRSs in schizophrenia patients performing aerobic exercise. A larger genetic risk burden was associated with a less pronounced volume increase or a decrease in volume over the course of the exercise intervention. Results of exploratory enrichment analyses reinforced the notion of genetic risk factors modulating biological processes tightly related to synaptic ion channel activity, calcium signaling, glutamate signaling and regulation of cell morphogenesis. We hypothesize that a high polygenic risk may negatively influence neuroplasticity in CA4/DG during aerobic exercise in schizophrenia. SN - 2158-3188 UR - https://www.unboundmedicine.com/medline/citation/28654095/Polygenic_risk_has_an_impact_on_the_structural_plasticity_of_hippocampal_subfields_during_aerobic_exercise_combined_with_cognitive_remediation_in_multi_episode_schizophrenia_ L2 - http://dx.doi.org/10.1038/tp.2017.131 DB - PRIME DP - Unbound Medicine ER -