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Oral contraceptives and breast cancer in young women.
Lancet. 1985 Nov 02; 2(8462):970-3.Lct

Abstract

The relation between use of oral contraceptives (OCs) by young women and their risk of breast cancer before 45 years of age was investigated by analysis of data from a population-based, case-control study conducted in eight geographic regions of the United States. 2088 women with breast cancer diagnosed between Dec 1, 1980, and Dec 31, 1982, were compared with 2065 controls selected during the same period. There was no significant increase or decrease in the risk of breast cancer for OC users according to age at first use or subsequent duration of use, even for women who first used OCs before the age of 20 years and who continued to use them for more than 4 years. Risk was not altered significantly for women who used OCs with high progestagen "potency" before the age of 25 years (even when duration of use exceeded 6 years), for those who used OCs before first-term pregnancy (even when duration of use exceeded 4 years), or for OC users according to age at diagnosis. These results suggest that use of OCs by young women in the United States has no effect on the aggregate risk of breast cancer before 45 years of age.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

2865503

Citation

Stadel, B V., et al. "Oral Contraceptives and Breast Cancer in Young Women." Lancet (London, England), vol. 2, no. 8462, 1985, pp. 970-3.
Stadel BV, Rubin GL, Webster LA, et al. Oral contraceptives and breast cancer in young women. Lancet. 1985;2(8462):970-3.
Stadel, B. V., Rubin, G. L., Webster, L. A., Schlesselman, J. J., & Wingo, P. A. (1985). Oral contraceptives and breast cancer in young women. Lancet (London, England), 2(8462), 970-3.
Stadel BV, et al. Oral Contraceptives and Breast Cancer in Young Women. Lancet. 1985 Nov 2;2(8462):970-3. PubMed PMID: 2865503.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Oral contraceptives and breast cancer in young women. AU - Stadel,B V, AU - Rubin,G L, AU - Webster,L A, AU - Schlesselman,J J, AU - Wingo,P A, PY - 1985/11/2/pubmed PY - 1985/11/2/medline PY - 1985/11/2/entrez KW - Age Factors KW - Americas KW - Breast Cancer KW - Cancer KW - Contraception KW - Contraceptive Agents KW - Contraceptive Agents, Female KW - Contraceptive Methods--side effects KW - Data Analysis KW - Demographic Factors KW - Developed Countries KW - Developing Countries KW - Diseases KW - Error Sources KW - Family Planning KW - Geographic Factors KW - Neoplasms KW - North America KW - Northern America KW - Oral Contraceptives--side effects KW - Population KW - Population Characteristics KW - Reliability KW - Research Methodology KW - Research Report KW - United States SP - 970 EP - 3 JF - Lancet (London, England) JO - Lancet VL - 2 IS - 8462 N2 - The relation between use of oral contraceptives (OCs) by young women and their risk of breast cancer before 45 years of age was investigated by analysis of data from a population-based, case-control study conducted in eight geographic regions of the United States. 2088 women with breast cancer diagnosed between Dec 1, 1980, and Dec 31, 1982, were compared with 2065 controls selected during the same period. There was no significant increase or decrease in the risk of breast cancer for OC users according to age at first use or subsequent duration of use, even for women who first used OCs before the age of 20 years and who continued to use them for more than 4 years. Risk was not altered significantly for women who used OCs with high progestagen "potency" before the age of 25 years (even when duration of use exceeded 6 years), for those who used OCs before first-term pregnancy (even when duration of use exceeded 4 years), or for OC users according to age at diagnosis. These results suggest that use of OCs by young women in the United States has no effect on the aggregate risk of breast cancer before 45 years of age. SN - 0140-6736 UR - https://www.unboundmedicine.com/medline/citation/2865503/Oral_contraceptives_and_breast_cancer_in_young_women_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0140-6736(85)90524-0 DB - PRIME DP - Unbound Medicine ER -