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Keratinocytes as sensors and central players in the immune defense against Staphylococcus aureus in the skin.
J Dermatol Sci 2017; 87(3):215-220JD

Abstract

Healthy human skin provides an effective mechanical as well as immunologic barrier against pathogenic microorganisms with keratinocytes as the main cell type in the epidermis actively participating and orchestrating the innate immune response of the skin. As constituent of the outermost layer encountering potential pathogens they have to sense signals from the environment and must be able to initiate a differential immune response to harmless commensals and harmful pathogens. Staphylococci are among the most abundant colonizers of the skin: Whereas Staphylococcus epidermidis is part of the skin microbiota and ubiquitously colonizes human skin, Staphylococcus aureus is only rarely found on healthy human skin, but frequently colonizes the skin of atopic dermatitis (AD) patients. This review highlights recent advances in understanding how keratinocytes as sessile innate immune cells orchestrate an effective defense against S. aureus in healthy skin and the mechanisms leading to an impaired keratinocyte function in AD patients.

Authors+Show Affiliations

Department of Dermatology, University of Tübingen, Tübingen, Germany.Interfaculty Institute of Microbiology and Infection Medicine, Medical Microbiology and Hygiene, University of Tübingen, Tübingen, Germany.Interfaculty Institute of Microbiology and Infection Medicine, Infection Biology, University of Tübingen, Tübingen, Germany.Interfaculty Institute of Microbiology and Infection Medicine, Infection Biology, University of Tübingen, Tübingen, Germany.Department of Dermatology, University of Tübingen, Tübingen, Germany. Electronic address: birgit.schittek@uni-tuebingen.de.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

28655473

Citation

Bitschar, Katharina, et al. "Keratinocytes as Sensors and Central Players in the Immune Defense Against Staphylococcus Aureus in the Skin." Journal of Dermatological Science, vol. 87, no. 3, 2017, pp. 215-220.
Bitschar K, Wolz C, Krismer B, et al. Keratinocytes as sensors and central players in the immune defense against Staphylococcus aureus in the skin. J Dermatol Sci. 2017;87(3):215-220.
Bitschar, K., Wolz, C., Krismer, B., Peschel, A., & Schittek, B. (2017). Keratinocytes as sensors and central players in the immune defense against Staphylococcus aureus in the skin. Journal of Dermatological Science, 87(3), pp. 215-220. doi:10.1016/j.jdermsci.2017.06.003.
Bitschar K, et al. Keratinocytes as Sensors and Central Players in the Immune Defense Against Staphylococcus Aureus in the Skin. J Dermatol Sci. 2017;87(3):215-220. PubMed PMID: 28655473.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Keratinocytes as sensors and central players in the immune defense against Staphylococcus aureus in the skin. AU - Bitschar,Katharina, AU - Wolz,Christiane, AU - Krismer,Bernhard, AU - Peschel,Andreas, AU - Schittek,Birgit, Y1 - 2017/06/10/ PY - 2017/05/30/received PY - 2017/06/02/revised PY - 2017/06/07/accepted PY - 2017/6/29/pubmed PY - 2018/5/11/medline PY - 2017/6/29/entrez KW - Atopic dermatitis KW - Immune response KW - Keratinocytes KW - Skin KW - Staphylococcus aureus SP - 215 EP - 220 JF - Journal of dermatological science JO - J. Dermatol. Sci. VL - 87 IS - 3 N2 - Healthy human skin provides an effective mechanical as well as immunologic barrier against pathogenic microorganisms with keratinocytes as the main cell type in the epidermis actively participating and orchestrating the innate immune response of the skin. As constituent of the outermost layer encountering potential pathogens they have to sense signals from the environment and must be able to initiate a differential immune response to harmless commensals and harmful pathogens. Staphylococci are among the most abundant colonizers of the skin: Whereas Staphylococcus epidermidis is part of the skin microbiota and ubiquitously colonizes human skin, Staphylococcus aureus is only rarely found on healthy human skin, but frequently colonizes the skin of atopic dermatitis (AD) patients. This review highlights recent advances in understanding how keratinocytes as sessile innate immune cells orchestrate an effective defense against S. aureus in healthy skin and the mechanisms leading to an impaired keratinocyte function in AD patients. SN - 1873-569X UR - https://www.unboundmedicine.com/medline/citation/28655473/Keratinocytes_as_sensors_and_central_players_in_the_immune_defense_against_Staphylococcus_aureus_in_the_skin_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0923-1811(17)30707-7 DB - PRIME DP - Unbound Medicine ER -