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Hesperidin attenuates inflammation and oxidative damage in pleural exudates and liver of rat model of pleurisy.
Redox Rep. 2017 Nov; 22(6):563-571.RR

Abstract

OBJECTIVES

This study investigated the potential anti-inflammatory effect of hesperidin against carrageenan induced pleurisy in rat model.

METHODS

Twenty-four adult female Wistar rats (350 - 450g) were grouped as follows: Group I: rats were administered saline solution only (Normal control group); Group II: rats were administered saline solution (NaCl 0.9%) orally and injected with carrageenan (Inflammation control group); Group III: rats were administered hesperidin only (Hesperidin group); Group IV: rats were administered hesperidin orally and intrapleurally injected with 2% carrageenan (Inflammation treated with hesperidin group). The exudate volume, total leukocyte count, reactive oxygen species (ROS), myeloperoxidase (MPO),δ-aminolevulinate dehydratase (δ-ALA-D), catalase (CAT), superoxide dismutase (SOD), activities as well as non-protein thiol group (NPSH) and thiobarbituric acid reactive substances (TBARS) levels were determined.

RESULTS

Pretreatment with hesperidin at a dose of 80 mg/kg orally per day for 21 days, minimized the increase in pleural exudate volume and leucocyte count and modulated the activities of MPO, SOD and CAT, as well as the levels of ROS, NPSH and TBARS in carrageenan-induced rats.

CONCLUSION

Our results suggest that hesperidin can elicit its anti-inflammatory action by blocking exudate and leukocyte influx into pleural cavity, inhibiting MPO activity and preventing oxidative damage.

Authors+Show Affiliations

a Department of Biochemistry , Functional Food and Nutraceutical Unit, Federal University of Technology , Akure , Nigeria. b Programa de Pós-Graduação em Ciências Biológicas: Bioquímica Toxicológica, Centro de Ciências Naturais e Exatas, Universidade Federal de Santa Maria , Santa Maria , Brazil. c Departamento de Microbiologia e Parasitologia , Centro de Ciências da Saúde, Universidade Federal de Santa Maria , Santa Maria , Brazil.b Programa de Pós-Graduação em Ciências Biológicas: Bioquímica Toxicológica, Centro de Ciências Naturais e Exatas, Universidade Federal de Santa Maria , Santa Maria , Brazil. c Departamento de Microbiologia e Parasitologia , Centro de Ciências da Saúde, Universidade Federal de Santa Maria , Santa Maria , Brazil.a Department of Biochemistry , Functional Food and Nutraceutical Unit, Federal University of Technology , Akure , Nigeria. b Programa de Pós-Graduação em Ciências Biológicas: Bioquímica Toxicológica, Centro de Ciências Naturais e Exatas, Universidade Federal de Santa Maria , Santa Maria , Brazil. d Department of Medical Biochemistry , Afe Babalola University , Ado Ekiti , Nigeria.a Department of Biochemistry , Functional Food and Nutraceutical Unit, Federal University of Technology , Akure , Nigeria.c Departamento de Microbiologia e Parasitologia , Centro de Ciências da Saúde, Universidade Federal de Santa Maria , Santa Maria , Brazil.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

28657497

Citation

Adefegha, Stephen Adeniyi, et al. "Hesperidin Attenuates Inflammation and Oxidative Damage in Pleural Exudates and Liver of Rat Model of Pleurisy." Redox Report : Communications in Free Radical Research, vol. 22, no. 6, 2017, pp. 563-571.
Adefegha SA, Rosa Leal DB, Olabiyi AA, et al. Hesperidin attenuates inflammation and oxidative damage in pleural exudates and liver of rat model of pleurisy. Redox Rep. 2017;22(6):563-571.
Adefegha, S. A., Rosa Leal, D. B., Olabiyi, A. A., Oboh, G., & Castilhos, L. G. (2017). Hesperidin attenuates inflammation and oxidative damage in pleural exudates and liver of rat model of pleurisy. Redox Report : Communications in Free Radical Research, 22(6), 563-571. https://doi.org/10.1080/13510002.2017.1344013
Adefegha SA, et al. Hesperidin Attenuates Inflammation and Oxidative Damage in Pleural Exudates and Liver of Rat Model of Pleurisy. Redox Rep. 2017;22(6):563-571. PubMed PMID: 28657497.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Hesperidin attenuates inflammation and oxidative damage in pleural exudates and liver of rat model of pleurisy. AU - Adefegha,Stephen Adeniyi, AU - Rosa Leal,Daniela Bitencourt, AU - Olabiyi,Ayodeji Augustine, AU - Oboh,Ganiyu, AU - Castilhos,Livia Gelain, Y1 - 2017/06/28/ PY - 2017/6/29/pubmed PY - 2018/6/12/medline PY - 2017/6/29/entrez KW - Hesperidin KW - antioxidant enzymes KW - carrageenan KW - inflammation KW - pleural exudate SP - 563 EP - 571 JF - Redox report : communications in free radical research JO - Redox Rep VL - 22 IS - 6 N2 - OBJECTIVES: This study investigated the potential anti-inflammatory effect of hesperidin against carrageenan induced pleurisy in rat model. METHODS: Twenty-four adult female Wistar rats (350 - 450g) were grouped as follows: Group I: rats were administered saline solution only (Normal control group); Group II: rats were administered saline solution (NaCl 0.9%) orally and injected with carrageenan (Inflammation control group); Group III: rats were administered hesperidin only (Hesperidin group); Group IV: rats were administered hesperidin orally and intrapleurally injected with 2% carrageenan (Inflammation treated with hesperidin group). The exudate volume, total leukocyte count, reactive oxygen species (ROS), myeloperoxidase (MPO),δ-aminolevulinate dehydratase (δ-ALA-D), catalase (CAT), superoxide dismutase (SOD), activities as well as non-protein thiol group (NPSH) and thiobarbituric acid reactive substances (TBARS) levels were determined. RESULTS: Pretreatment with hesperidin at a dose of 80 mg/kg orally per day for 21 days, minimized the increase in pleural exudate volume and leucocyte count and modulated the activities of MPO, SOD and CAT, as well as the levels of ROS, NPSH and TBARS in carrageenan-induced rats. CONCLUSION: Our results suggest that hesperidin can elicit its anti-inflammatory action by blocking exudate and leukocyte influx into pleural cavity, inhibiting MPO activity and preventing oxidative damage. SN - 1743-2928 UR - https://www.unboundmedicine.com/medline/citation/28657497/Hesperidin_attenuates_inflammation_and_oxidative_damage_in_pleural_exudates_and_liver_of_rat_model_of_pleurisy_ L2 - https://www.tandfonline.com/doi/full/10.1080/13510002.2017.1344013 DB - PRIME DP - Unbound Medicine ER -